Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Li, Maoyu; Meng, Yahui; Wang, Minzhong; Yang, Shuang; Wu, Hui; Zhao, Bin; Wang, Guangbin

doi:10.1002/brb3.745

Cited by 42 publications

(34 citation statements)

References 32 publications

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“…We observed that the increased connections between the right FFG and left presubiculum were stronger in svMCI than in the aMCI and NC groups. Previous studies have shown FFG atrophy in svMCI patients ( 24 , 54 ). The FFG is related to semantic processing ( 55 ).…”

Section: Discussionmentioning

confidence: 81%

Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients

Wang

Zhao

et al. 2018

Front. Neurol.

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The hippocampus plays important roles in memory processing. However, the hippocampus is not a homogeneous structure, which consists of several subfields. The hippocampal subfields are differently affected by many neurodegenerative diseases, especially mild cognitive impairment (MCI). Amnestic mild cognitive impairment (aMCI) and subcortical vascular mild cognitive impairment (svMCI) are the two subtypes of MCI. aMCI is characterized by episodic memory loss, and svMCI is characterized by extensive white matter hyperintensities and multiple lacunar infarctions on magnetic resonance imaging. The primary cognitive impairment in svMCI is executive function, attention, and semantic memory. Some variations or disconnections within specific large-scale brain networks have been observed in aMCI and svMCI patients. The aim of this study was to investigate abnormalities in structural covariance networks (SCNs) between hippocampal subfields and the whole cerebral cortex in aMCI and svMCI patients, and whether these abnormalities are different between the two groups. Automated segmentation of hippocampal subfields was performed with FreeSurfer 5.3, and we selected five hippocampal subfields as the seeds of SCN analysis: CA1, CA2/3, CA4/dentate gyrus (DG), subiculum, and presubiculum. SCNs were constructed based on these hippocampal subfield seeds for each group. Significant correlations between hippocampal subfields, fusiform gyrus (FFG), and entorhinal cortex (ERC) in gray matter volume were found in each group. We also compared the differences in the strength of structural covariance between any two groups. In the aMCI group, compared to the normal controls (NC) group, we observed an increased association between the left CA1/CA4/DG/subiculum and the left temporal pole. Additionally, the hippocampal subfields (bilateral CA1, left CA2/3) significantly covaried with the orbitofrontal cortex in the svMCI group compared to the NC group. In the aMCI group compared to the svMCI group, we observed decreased association between hippocampal subfields and the right FFG, while we also observed an increased association between the bilateral subiculum/presubiculum and bilateral ERC. These findings provide new evidence that there is altered whole-brain structural covariance of the hippocampal subfields in svMCI and aMCI patients and provide insights to the pathological mechanisms of different MCI subtypes.

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Section: Discussionmentioning

confidence: 81%

Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients

Wang

Zhao

et al. 2018

Front. Neurol.

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“…We hypothesized that individuals who prioritized cognition (i.e., cogDTE decreases less than mDTE) and individuals who prioritized motor function (i.e., mDTE decreases less than cogDTE) would have had different associations with motor and cognitive relevant brain areas. Based on the literature, we hypothesized that level of task prioritization will be associated with volumes in the caudate, anterior cingulate, medial orbital frontal, inferior frontal, superior temporal, and parahippocampal regions (Holtzer et al 2016;Li et al 2017;Zheng et al 2014). The third aim of this study was to determine how general automaticity, as represented by combined dualtask effect (cDTE), was associated with brain regions and gait/balance impairments.…”

Section: Introductionmentioning

confidence: 99%

“…We hypothesized that the cDTE would be associated with more brain volumes and gait/balance impairments than either the motor or cognitive DTEs. Based on the literature, with automaticity we hypothesized that superior frontal, inferior frontal, lateral orbitofrontal, caudate, anterior cingulate, entorhinal, and parahippocampal regions would correlate with cDTE (Allali et al 2019;Li et al 2017;Poldrack et al 2005;Sakurai et al 2019;Tripathi et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Brain volumes and dual-task performance correlates among individuals with cognitive impairment: a retrospective analysis

et al. 2020

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Cognitive impairment (CI) is a prevalent condition characterized by loss of brain volume and changes in cognition, motor function, and dual-tasking ability. To examine associations between brain volumes, dual-task performance, and gait and balance in those with CI to elucidate the mechanisms underlying loss of function. We performed a retrospective analysis of medical records of patients with CI and compared brain volumes, dual-task performance, and measures of gait and balance. Greater cognitive and combined dual-task effects (DTE) are associated with smaller brain volumes. In contrast, motor DTE is not associated with distinct pattern of brain volumes. As brain volumes decrease, dual-task performance becomes more motor prioritized. Cognitive DTE is more strongly associated with decreased performance on measures of gait and balance than motor DTE. Decreased gait and balance performance are also associated with increased motor task prioritization. Cognitive DTE appears to be more strongly associated with decreased automaticity and gait and balance ability than motor DTE and should be utilized as a clinical and research outcome measure in this population. The increased motor task prioritization associated with decreased brain volume and function indicates a potential for accommodative strategies to maximize function in those with CI. Counterintuitive correlations between motor brain volumes and motor DTE in our study suggest a complicated interaction between brain pathology and function.

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“…Esto permitiría inferir que los efectos protectores de la RC sobre la cognición disminuyen frente a una gran atrofia cerebral 33 . Estos hallazgos son consistentes con estudios previos de demencia vascular, donde se observó que las repercusiones cognitivas no logran ser atenuadas debido a una disminución considerable en los volúmenes de sustancia gris 34,35 .…”

Section: Demencias Y Rcunclassified

Reserva cognitiva y demencias: Limitaciones del efecto protector en el envejecimiento y el deterioro cognitivoLimited protective effects of cognitive reserve on the progression of cognitive impairment

Toloza-Ramírez

Martella

2019

Rev. méd. Chile

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Limited protective effects of cognitive reserve on the progression of cognitive impairment Aging constitutes a series of physical, physiological and cognitive changes, affecting independence in the activities of daily living. During this stage, neurodegenerative diseases and cognitive impairment are common. Cognitive Reserve allows to face neuropathological changes and maintain cognitive function in the presence of brain damage. However, there are cases where a high cognitive reserve fails to attenuate and delay the effects of neuropathology, allowing the progression of cognitive damage to advanced stages. The objective of this systematic review is to identify evidence where high cognitive reserve does not limit the effects of cognitive impairment. Results indicate that the protective effect of cognitive reserve occurs only in the presence of minimal cognitive impairment, but not at later stages.

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Cerebral gray matter volume reduction in subcortical vascular mild cognitive impairment patients and subcortical vascular dementia patients, and its relation with cognitive deficits

Abstract: Introduction: Subcortical vascular mild cognitive impairment (svMCI) is the predemen-

Cited by 42 publications

References 32 publications

Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients

Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients

Brain volumes and dual-task performance correlates among individuals with cognitive impairment: a retrospective analysis

Reserva cognitiva y demencias: Limitaciones del efecto protector en el envejecimiento y el deterioro cognitivoLimited protective effects of cognitive reserve on the progression of cognitive impairment

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