Cerebral Ischemic Postconditioning Plays a Neuroprotective Role through Regulation of Central and Peripheral Glutamate

You, Jiulin; Feng, Lei; Xin, Meiying; Ma, Di; Feng, Jiachun

doi:10.1155/2018/6316059

Cited by 22 publications

(15 citation statements)

References 85 publications

(134 reference statements)

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“…In diabetes, hippocampal Glu content is increased and mGluR2/3 subtype receptors are hyperstimulated [29]. Stimulation of mGluR2/3 activates the downstream ERK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats

Zhuo

Han

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Objectives. Diabetes mellitus is frequently accompanied by depression (diabetes−depression, DD), and DD patients are at higher risk of diabetes-related disability and mortality than diabetes patients without depression. Hippocampal degeneration is a major pathological feature of DD. Here, we investigated the contribution of the Glu−mGluR2/3−ERK signaling pathway to apoptosis of hippocampal neurons in DD model rats. Methods. The DD model was established by high-fat diet (HFD) feeding and streptozotocin (STZ) injection followed by chronic unpredictable mild stress (CUMS). Other groups were subjected to HFD + STZ only (diabetes alone) or CUMS only (depression alone). Deficits in hippocampus-dependent memory were assessed in the Morris water maze (MWM), motor activity in the open field test (OFT), and depression-like behavior in the forced swim test (FST). Terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) was used to estimate the rate of hippocampal neuron apoptosis. Hippocampal glutamate (Glu) content was measured by high performance liquid chromatography. Hippocampal expression levels of mGluR2/3, ERK, and the apoptosis effector caspase-3 were estimated by immunohistochemistry and Western blotting. Results. DD model rats demonstrated more severe depression-like behavior in the FST, greater spatial learning and memory deficits in the MWM, and reduced horizontal and vertical activity in the OFT compared to control, depression alone, and diabetes alone groups. All of these abnormalities were reversed by treatment with the mGluR2/3 antagonist LY341495. The DD group also exhibited greater numbers of TUNEL-positive hippocampal neurons than all other groups, and this increased apoptosis rate was reversed by LY341495. In addition, hippocampal expression levels of caspase-3 and mGluR2/3 were significantly higher, ERK expression was lower, and Glu was elevated in the DD group. The mGluR2//3 antagonist significantly altered all these features of DD. Conclusions. Comorbid diabetes and depression are associated with enhanced hippocampal neuronal apoptosis and concomitantly greater hippocampal dysfunction. These pathogenic effects are regulated by the Glu−mGluR2/3−ERK signaling pathway.

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“…In diabetes, hippocampal Glu content is increased and mGluR2/3 subtype receptors are hyperstimulated [29]. Stimulation of mGluR2/3 activates the downstream ERK signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats

Zhuo

Han

Zhao

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Ischemia is known to cause an early wave of glutamatergic excitotoxicity on depolarizing or dying neurons, resulting in breakdown of the homeostatic and water balances. Interestingly, several genes such as GAD1, GJB6, GJD2, and AQP4 known to be induced or repressed by those early events of stroke (71)(72)(73)(74) are regulated in an opposite manner by PACAP which contributes to explain how PACAP protects the brain after stroke. For instance, PACAP by inhibiting AQP4, reduces brain oedema, and promotes cell survival after MCAO (75,76).…”

Section: Gene Expressionmentioning

confidence: 99%

Intranasal Administration of PACAP Is an Efficient Delivery Route to Reduce Infarct Volume and Promote Functional Recovery After Transient and Permanent Middle Cerebral Artery Occlusion

et al. 2021

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Intranasal (IN) administration appears to be a suitable route for clinical use as it allows direct delivery of bioactive molecules to the central nervous system, reducing systemic exposure and sides effects. Nevertheless, only some molecules can be transported to the brain from the nasal cavity. This led us to compare the efficiency of an IN, intravenous (IV), and intraperitoneal (IP) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) after transient or permanent middle cerebral artery occlusion (MCAO) in C57BL/6 mice. The results show that the neuroprotective effect of PACAP is much more efficient after IN administration than IV injection while IP injection had no effect. IN administration of PACAP reduced the infarct volume when injected within 6 h after the reperfusion and improved functional recovery up to at least 1 week after the ischemia.

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“…Одним із шляхів реагування печінки на ішемію-реперфузію головного мозку вважається посилення синтезу печінкою ферментів, причетних до метаболізму токсичного глутамату, який, як відомо, у надмірних кількостях утворюється в ішемізованій зоні внаслідок активації глутаматного каскаду [6,7].…”

Section: основна частинаunclassified

Modern Views on Interdependence of Morphofunctional State of the Liver, Spleen and Brain Under Conditions of Ischemiareperfusion of the Brain

Ткачук¹,

Tkachuk²,

Povar³

et al. 2020

Clin. and experim. pathol.

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Вищий державний навчальний заклад України "Буковинський державний медичний університет" м.Чернівці Мета роботи-проаналізувати дані літератури стосовно взаємозв'язків між ішемічно-реперфузійними пошкодженнями головного мозку та морфофункціональним станом печінки і селезінки. Висновок. Аналіз наявних у літературі наукових фактів переконливо доводить наявність двобічних взаємозв'язків між ішемічно-реперфузійним ушкодженням головного мозку та морфофункціональним станом печінки і селезінки. Ключові слова: церебральна ішемія-реперфузія, печінка, селезінка. Клиническая и экспериментальная патология Т.18, №4 (70). С.120-126.

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Cerebral Ischemic Postconditioning Plays a Neuroprotective Role through Regulation of Central and Peripheral Glutamate

Cited by 22 publications

References 85 publications

Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats

Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats

Intranasal Administration of PACAP Is an Efficient Delivery Route to Reduce Infarct Volume and Promote Functional Recovery After Transient and Permanent Middle Cerebral Artery Occlusion

Modern Views on Interdependence of Morphofunctional State of the Liver, Spleen and Brain Under Conditions of Ischemiareperfusion of the Brain

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