Cerebral Oxygenation During Hypoxia and Resuscitation by Using Near-infrared Spectroscopy in Newborn Piglets

Chien, Jen Chung; Jeng, Mei Jy; Chang, Hua Lun; Lee, Yu Sheng; Lee, Pi Chang; Soong, Wen‐Jue; Hwang, Betau

doi:10.1016/s1726-4901(09)70301-6

Cited by 14 publications

(8 citation statements)

References 26 publications

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“…4 ). When brain tissue has been damaged or is dying, low cFTOE can be predicted [12] . The presence of low cFTOE as a negative prognostic factor might be correlated to the difference in overall mortality rate between the groups in our study.…”

Section: Discussionmentioning

confidence: 99%

Resuscitation of Severely Asphyctic Newborn Pigs with Cardiac Arrest by Using 21% or 100% Oxygen

Solevåg¹,

Dannevig²,

Nakstad

et al. 2010

Neonatology

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Background: In spite of evidence suggesting that resuscitation with 100% O₂ is detrimental, international guidelines still recommend its use. Clinical studies comparing 21% and 100% O₂ included many infants with only mild and moderate asphyxia. Objectives: We aimed to investigate the effect of these oxygen fractions on haemodynamic parameters, arterial blood gases, oxygen saturation indices and markers of inflammation and hypoxic damage when resuscitating asystolic newborn pigs following asphyxia. Methods: Newborn swine (n = 32, age 12–36 h, weight 2.0–2.7 kg) were progressively asphyxiated until asystole occurred. Cardiopulmonary resuscitation was initiated with ventilation with either 21% (n = 16) or 100% O₂ (n = 16). Return of spontaneous circulation (ROSC) was defined as a heart rate ≧100 min^–1. Results: Mean time of hypoxia, pH, base excess and pCO₂ at asystole were comparable between the groups. All animals except 2 in the 100% group achieved ROSC. One animal in the 21% group suffered bradycardia at baseline and was excluded. For the remaining 15 animals resuscitated with 21% O₂, median time to ROSC (interquartile range) was 150 s (115–180), whereas animals in the 100% group achieved ROSC after 135 s (113–168); p = 0.80. There were no differences in the temporal changes in mean arterial blood pressure, heart rate, pH, pCO₂, interleukin-1β or lactate/pyruvate ratios. However, systemic and regional cerebral oxygen saturations were higher in the animals resuscitated with 100% oxygen. Conclusion: In this animal model of severe perinatal asphyxia, resuscitation with room air seemed to be as safe and effective as the use of 100% oxygen.

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Section: Discussionmentioning

confidence: 99%

Resuscitation of Severely Asphyctic Newborn Pigs with Cardiac Arrest by Using 21% or 100% Oxygen

Solevåg¹,

Dannevig²,

Nakstad

et al. 2010

Neonatology

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“…[9][10][11] When hemodynamics has been studied during cardiac arrest, only global hemodynamic parameters have been analyzed. 4,5,12 Very few studies have analyzed tissue perfusion parameters in such setting 13,14 and no references are available about the eventual correlation between global hemodynamic and tissue perfusion parameters during asphyctic cardiac arrest and resuscitation.…”

Section: Introductionmentioning

confidence: 99%

Correlations between hemodynamic, oxygenation and tissue perfusion parameters during asphyxial cardiac arrest and resuscitation in a pediatric animal model

López‐Herce¹,

Fernández²,

Urbano³

et al. 2011

Resuscitation

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“…8,9 NIRS has also been used to study infant and adult changes in cerebral oxygen utilization during periods of sepsis, transient hypoxia, mental work, surgery, cardiopulmonary bypass surgery, extracorporeal membrane oxygenation and intensive resuscitation. 10e13 However, regional cerebral oxygen saturation (rScO 2 ) changes during volume expansion therapy in hemorrhagic shock events have not been well investigated.…”

Section: Introductionmentioning

confidence: 99%

Effects of fluid resuscitation on cerebral tissue oxygenation changes in a piglet model of hemorrhagic shock

Chien

Jeng

Soong

et al. 2011

Journal of the Chinese Medical Association

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Effective resuscitation using a high concentration of inspired oxygen and adequate fluid infusion, either as a single-dose bolus of NS or combining this with a subsequent transfusion of WB, LR, or NS, helped to stabilize the cardiovascular condition of the tested young subjects and improved cerebral tissue oxygenation over the emergent first four hours. Furthermore, WB was the best fluid choice when used in addition to the bolus NS challenge for maintaining better brain tissue oxygenation when treating hemorrhagic shock.

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Cerebral Oxygenation During Hypoxia and Resuscitation by Using Near-infrared Spectroscopy in Newborn Piglets

Abstract: Noninvasive monitoring of rScO2 and evaluating FTOE changes during hypoxia and resuscitation may help clinicians evaluate brain tissue oxygenation and viability.

Cited by 14 publications

References 26 publications

Resuscitation of Severely Asphyctic Newborn Pigs with Cardiac Arrest by Using 21% or 100% Oxygen

Resuscitation of Severely Asphyctic Newborn Pigs with Cardiac Arrest by Using 21% or 100% Oxygen

Correlations between hemodynamic, oxygenation and tissue perfusion parameters during asphyxial cardiac arrest and resuscitation in a pediatric animal model

Effects of fluid resuscitation on cerebral tissue oxygenation changes in a piglet model of hemorrhagic shock

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