Cerebral venous sinus thrombosis: An unusual initial presentation of mucinous adenocarcinoma of stomach

Jena, Subhransu Sekhar; Nayak, Soumyadarshan; Behera, Ishwar Chandra; Mohapatra, Debahuti; Tripathy, Subrat Kumar

doi:10.4103/0028-3886.149416

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with the clinicopathological features, computerized tomography scan features, and molecular and genetic features of the gastric mucinous adenocarcinoma, the RAS/RAF/MAPK and PI3K/AKT pathways showed different mutation rates (26)(27)(28). The prognosis of gastric mucinous adenocarcinoma varies greatly based on different histopathological diagnostic criteria (26)(27)(28). The diagnosis is affected by the different tissues and proportions of cells of the adenocarcinoma.…”

Section: Discussionmentioning

confidence: 90%

Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation

Meng¹,

Wang²,

Wang³

et al. 2022

Front. Med.

View full text Add to dashboard Cite

ObjectiveTo discuss the histological features, pathological types, and prognosis of gastric adenocarcinoma with mucinous differentiation.MethodsSpecimens of 189 cases of gastric adenocarcinoma with mucinous differentiation were collected for detailed histomorphology, immunohistochemistry, fluorescence in situ hybridization, and follow-up.ResultsIn accordance with the morphological and histological structural features of the cancer cells as well as the area ratio of the mucus, gastric adenocarcinoma with mucinous differentiation was divided into four types, namely pure mucinous carcinoma, intraductal papillary mucinous carcinoma, signet ring cell type mucinous carcinoma, and mixed cell type mucinous carcinoma. Based on the macroscopic types according to Bormann's classification, pure mucinous carcinoma was mostly Type I, intraductal papillary mucinous carcinoma was mostly Type II, signet ring cell type mucinous carcinoma was mostly Type IV, and mixed cell type mucinous carcinoma was mostly Type III. The 5-year survival rate was 69.2, 64.2, 0, and 31.5%, respectively. There was a statistical difference in the lymph node metastasis rate and survival rate of the four carcinoma types. The invasion features of pure mucinous carcinoma entailed penetrating corrosively in a push-in form, without blood vessel or lymphatic metastasis and with few lymphocytes and lymphatic nodules in the marginal area. Thus, there was little lymph node metastasis and invasion of nerves. The HER2 protein expression rate was 40.2% (76/189), the HER2 gene amplification detected by FISH technology was 16.9% (32/189).ConclusionThe independent histological type, four subtypes, and histopathological classification of gastric mucinous adenocarcinoma are important for the prognosis evaluation and precise treatment of this disease.

show abstract

Section: Discussionmentioning

confidence: 90%

Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation

Meng¹,

Wang²,

Wang³

et al. 2022

Front. Med.

View full text Add to dashboard Cite

show abstract

“…CVST representing the initial manifestation of occult cancer had been found in previous studies. [21–24] It was suggested that CVST patients with unknown pathogenesis should take measures to screen out concealing cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Further multivariate logistic regression analysis revealed that the elevated levels of CA125 and CEA may independently increase the risk of somatic cancer-related CVST group. Mucin produced by cancer cells was suspected to contribute to cancer-related hypercoagulability and may indirectly lead to CVST; [21] as previous animal experiments have demonstrated that mucins secreted by cancer cells could trigger the reciprocal activation of platelets through adhesion-dependent, bidirectional signaling in neutrophils and platelets, and then trigger the formation of microthromboembolism in the blood; [27] and as CA125 and CEA are also mucins produced by cancer cells, it was suggested that cancer cells introduced mucinous substances, such as CA125 and CEA, into the bloodstream to cause the formation of microthromboembolism in the blood, which, in turn, led to hypercoagulability and triggered the development of cancer-related CVST. Based on the findings mentioned above, in the present study it was suggested that elevated plasma CA125 and CEA levels in patients with CVST may trigger the cancer-related CVST by causing the formation of microthromboembolism in the blood.…”

Section: Discussionmentioning

confidence: 99%

A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis

Xian

Chen

et al. 2019

Medicine

View full text Add to dashboard Cite

To investigate the pathogenesis of somatic solid cancer-related cerebral venous sinus thrombosis (CVST). A total of 174 patients with CVST were recruited from the hospital between January 2006 and December 2017 and divided into two groups: (1) somatic cancer-related CVST group, defined as active somatic solid cancer patients with acute CVST; (2) cancer group (CG), defined as active somatic solid cancer patients without CVST. The cancer group patients were age and gender-matched somatic cancer-related CVST group patients. In addition, the types and amount distribution of cancer in cancer group were also matched with somatic cancer-related CVST group patients. Compared to cancer group patients, somatic cancer-related CVST group patients had more intracranial metastasis, a higher platelet count, higher plasma D-dimer, carcinoembryonic antigen (CEA) and cancer antigen (CA) 125 levels, a greater platelet to lymphocyte ratio (PLR), and a greater platelet to neutrophil ratio (PNR). The risk for CVST in somatic cancer-related CVST group patients increased independently by 0.7% (odds ratio [OR] 1.007; 95% confidence interval [CI] 1.000, 1.015; P = .047) with a 1 ng/ml increase in D-dimer levels, by 4.6% (OR 1.046; 95% CI 1.011, 1.083; P = .010) with a 1 U/ml increase in CEA, by 2.7% (OR 1.027; 95% CI 1.003, 1.051; P = .025) with a 1 U/ml increase in CA125, and by 10.6% (OR 1.106; 95% CI 1.002, 1.220; P = .045) with a 1 unit increase in PNR. It was suggested that together impacts of elevated plasma D-dimer, CA125, CEA levels, and a greater PNR may lead to hypercoagulability and to trigger the development of cancer-related CVST.

show abstract

Headache as Complication of Cancer

Ranjan

Schiff

2017

Cancer Neurology in Clinical Practice

View full text Add to dashboard Cite

Cerebral venous sinus thrombosis: An unusual initial presentation of mucinous adenocarcinoma of stomach

Cited by 3 publications

References 0 publications

Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation

Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation

A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis

Headache as Complication of Cancer

Contact Info

Product

Resources

About