Cerebral Venous Sinus Thrombosis May Follow a Seasonal Pattern

Salehi, Golshan; Sarraf, Payam; Fatehi, Farzad

doi:10.1016/j.jstrokecerebrovasdis.2016.07.045

Cited by 18 publications

(13 citation statements)

References 25 publications

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“…Given our large sample size, all patients being from the same geographical region with similar climatic conditions and also the consistency of the correlation over an 18-year period make the results more robust. Our findings were similar to a study from Iran,[ 4 ] which however had a much smaller number of cases.…”

Section: Discussionsupporting

confidence: 91%

“…There are many established risk factors for CVT[ 3 ]; however studies trying to associate CVT and seasonal variations are few and conflicting. In a study from Iran[ 4 ] which looked at 165 CVT admissions over a 10-year period, there was higher incidence in the hot months. A Portuguese[ 5 ] study showed peak incidence of the onset of CVT Symptoms in the autumn and winter.…”

Section: Introductionmentioning

confidence: 99%

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Cerebral venous thrombosis, seasonal trends, and climatic influence: A region-specificstudy

Aaron

Lakshmanan

Sudarsanam

et al. 2020

Ann Indian Acad Neurol

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Background and Purpose: Studies looking at seasonal variation on cerebral venous thrombosis (CVT) are few with conflicting conclusions. In this region-specific study, we looked for climatic influence and seasonal trends on the incidence of CVT. Methods: Imaging proven adult CVT cases treated over a period of 18 years from a specific geographical location with similar seasons and climatic conditions were studied. Metrological parameters prepared using 30 years of data was used. Quantum geographical information system (QGIS software) and SPSS v 22 were used for patient plotting and analysis. Results: Total of 970 cases were studied. The incidence was significantly higher in summer 411 (42.3%) compared with autumn 317 (32.7%) and winter 242 (25.05); P = 0.038. This trend was consistent across all the 18 years in time series analysis. Mean age was 33.5 years (range 18–88 years). A significant majority 673 (69.4%) were below 40 years of age; P = 0.012. Females constituted 394 (40.6%) of cases. Postpartum CVT cases constituted 237 (30%). Interaction analysis showed younger age (<40 years) were more vulnerable for CVT in summer; P = 0.009. There was no seasonal influence on postpartum CVT. Apart for a weak positive correlation between rain fall ( r = 0.18, P < 0.01); humidity and cloud cover was not influencing the incidence. Conclusions: Higher ambient temperatures were consistently associated with higher incidence of CVT. This is the largest region-specific study on CVT in the world. These results may be applicable to other regions with similar climatic conditions.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Cerebral venous thrombosis, seasonal trends, and climatic influence: A region-specificstudy

Aaron

Lakshmanan

Sudarsanam

et al. 2020

Ann Indian Acad Neurol

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“…This dataset was driven from a previous retrospective cohort study [ 20 ]. We intended to match the cohorts in terms of seasonal variation since the CVST characteristics and risk factors may follow a seasonal pattern [ 21 ]. The studied variables and their definitions, the units, and the methods of observation were reviewed in the control group to ascertain that they are consistent between the cases and the control group.…”

Section: Methodsmentioning

confidence: 99%

Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series

Mowla

Shakibajahromi

Shahjouei

et al. 2020

Journal of the Neurological Sciences

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Background SARS-CoV-2 induced coagulopathy can lead to thrombotic complications such as stroke. Cerebral venous sinus thrombosis (CVST) is a less common type of stroke which might be triggered by COVID-19. We present a series of CVST cases with SARS-CoV-2 infection. Methods In a multinational retrospective study, we collected all cases of CVST in SARS-CoV-2 infected patients admitted to nine tertiary stroke centers from the beginning of the pandemic to June 30th, 2020. We compared the demographics, clinical and radiological characteristics, risk factors, and outcome of these patients with a control group of non-SARS-CoV-2 infected CVST patients in the same seasonal period of the years 2012–2016 from the country where the majority of cases were recruited. Results A total of 13 patients fulfilled the inclusion criteria (62% women, mean age 50.9 ± 11.2 years). Six patients were discharged with good outcomes (mRS ≤ 2) and three patients died in hospital. Compared to the control group, the SARS-CoV-2 infected patients were significantly older (50.9 versus 36.7 years, p < 0.001), had a lower rate of identified CVST risk factors (23.1% versus 84.2%, p < 0.001), had more frequent cortical vein involvement (38.5% versus 10.5%, p : 0.025), and a non-significant higher rate of in-hospital mortality (23.1% versus 5.3%, p : 0.073). Conclusion CVST should be considered as potential comorbidity in SARS-CoV-2 infected patients presenting with neurological symptoms. Our data suggest that compared to non-SARS-CoV-2 infected patients, CVST occurs in older patients, with lower rates of known CVST risk factors and might lead to a poorer outcome in the SARS-CoV-2 infected group.

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“…15 16 17 Most previous studies focused exclusively on deep vein thrombosis and pulmonary embolism. 7 8 9 10 11 12 13 14 15 16 17 Studies on cerebral vein thrombosis seasonality have been small (<200 patients) and inconclusive, 18 19 20 while, to the best of our knowledge, no previous study has investigated the seasonality of splanchnic vein thrombosis and retinal vein thrombosis. As improved imaging modalities lead to more accurate diagnoses, it may be time to revisit earlier findings.…”

Section: Introductionmentioning

confidence: 94%

Venous Thromboembolism in Denmark: Seasonality in Occurrence and Mortality

Skajaa

Horváth‐Puhó

Adelborg

et al. 2019

TH Open

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Background Many cardiovascular conditions exhibit seasonality in occurrence and mortality, but little is known about the seasonality of venous thromboembolism. Methods Using Danish registries, we identified all patients with deep vein thrombosis, pulmonary embolism, splanchnic vein thrombosis, cerebral vein thrombosis, and retinal vein thrombosis during 1977–2016. We tallied monthly deaths occurring within 90 days of the venous thromboembolism diagnosis. We estimated peak-to-trough ratios and timing of the peak of both diagnoses and deaths summed over all years of the study period. The departure from 1.0 of the peak-to-trough ratio measures the intensity of any seasonal pattern. Results We estimated a peak-to-trough ratio of 1.09 (95% confidence interval: 1.07–1.11) for deep vein thrombosis and 1.22 (1.19–1.24) for pulmonary embolism occurrence. The peak-to-trough ratios for splanchnic vein thrombosis, cerebral vein thrombosis, and retinal vein thrombosis occurrence were 1.10 (1.01–1.20), 1.19 (1.00–1.40), and 1.12 (1.07–1.17), respectively. The occurrence of all conditions peaked during winter or fall. In time trend analyses, the peak-to-trough ratio increased considerably for splanchnic vein thrombosis, cerebral vein thrombosis, and retinal vein thrombosis occurrence. In associated mortality, the peak-to-trough ratio for deep vein thrombosis was larger (1.15, 1.07–1.23) than that for pulmonary embolism (1.04, 1.01–1.08). Discussion Excess winter risks were modest, but more marked for pulmonary embolism occurrence than for deep vein thrombosis occurrence. The seasonal pattern intensified throughout the study period for splanchnic vein thrombosis, cerebral vein thrombosis, and retinal vein thrombosis. The winter peak in mortality following pulmonary embolism was smaller than that for deep vein thrombosis.

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Cerebral Venous Sinus Thrombosis May Follow a Seasonal Pattern

Cited by 18 publications

References 25 publications

Cerebral venous thrombosis, seasonal trends, and climatic influence: A region-specificstudy

Cerebral venous thrombosis, seasonal trends, and climatic influence: A region-specificstudy

Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series

Venous Thromboembolism in Denmark: Seasonality in Occurrence and Mortality

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