Cerebriform intradermal nevus. A cause of cutis verticis gyrata

Orkin, Milton

doi:10.1001/archderm.110.4.575

Cited by 41 publications

(40 citation statements)

References 18 publications

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“…Presenting at birth or early life, it is attributed that females are more likely to develop this condition [7]. It can be either asymptomatic or can be associated with progressive alopecia, pruritus, tenderness, burning, bleeding and fetid odor [9,10]. Our patient was female and had mild occasional itching and also alopecia confined to the nevus since birth.…”

Section: Discussionmentioning

confidence: 96%

Cerebriform intradermal nevus-A rare clinical entity presenting as cutis verticis gyrata

Kudligi¹,

Kuntoji²,

Bhagwat³

et al. 2017

Our Dermatol Online

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Section: Discussionmentioning

confidence: 96%

Cerebriform intradermal nevus-A rare clinical entity presenting as cutis verticis gyrata

Kudligi¹,

Kuntoji²,

Bhagwat³

et al. 2017

Our Dermatol Online

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“…Although they looked similar to previous disease entities, including nevus lipomatous superficialis and cerebriform nevus, they could be distinguished based upon histopathological findings. Nevus lipomatous superficialis demonstrates groups or strands of fat cells instead of scattered ones 8 , and cerebriform nevus dose not reveal fatty degeneration or fibrosis 9 . Therefore they named the lesions "lobulated intradermal nevus" and suggested their cases represented an unusual form of regressing melanocytic nevus.…”

Section: Discussionmentioning

confidence: 99%

Four Cases of Lobulated Intradermal Nevus: A Sign of Aging Melanocytic Nevus

et al. 2011

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“…The lesions gradually begin to take on their brain-like appearance which leads to alopecia in addition to the possibility of itching, bleeding, secondary infections and foul smell, due to bacterial proliferation in the folds. 8 The social and esthetic repercussions of CIN make it extremely important.…”

Section: Traumamentioning

confidence: 99%

Nevo intradérmico cerebriforme como causa de Cutis verticis gyrata

Filho¹,

Darrigo

Avelleira

et al. 2010

Rev. Assoc. Med. Bras.

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Cerebriform intradermal nevus as a Cause of cutis verticis gyrata 639Rev Assoc Med Bras 2010; 56(6): Cutis verticis gyrata (CVG) is a rare disease that is characterized by excess scalp skin, producing thick folds that form creases and ridges similar in appearance to the whorls of the cerebral cortex. It was first described in the literature by Robert in 1843 and the name cutis verticis gyrata was proposed by Unna in 1907 and remains the accepted name to date. 1,2 It has an estimated prevalence of one case in every 100,000 men and 0,026 cases for every 100,000 women. 3 It can be an isolated manifestation that is present from birth or it can be part of other syndromes.Cutis verticis gyrata is classified as primary (subdivided into essential and non essential) or secondary. The essential primary form is not associated with neurological or ophthalmological disorders, and only the folds on the scalp mimicking the cerebral whorls appear. It appears in puberty and affects more men than women. The non essential primary form affects 0.5% of patients with mental retardation. Cerebral palsy, epilepsy, cataracts and blindness may also be present. 2,4,5,6 The secondary forms of CVG generally occur as a result of inflammatory or neoplastic processes that cause changes to the structure of the scalp. 2,6 One of the rarest forms of secondary CVG is the nevoid form, in which it is melanocytic intradermal nevi that cause the cutaneous hypertrophy. This condition is known as cerebriform intradermal nevus (CIN) and was first linked with CVG in 1937 by Hammond and Ransom. 7 Patients affected by CIN have normal intelligence and are free from other local or systemic diseases.The objective of this paper is to describe a rare case of cerebriform intradermal nevus, discussing its histopathological and clinical features. CaseA white female patient, 43 years old, presented at the Instituto de Dermatologia Professor Azulay with large dimension lesions on the scalp. She stated that at birth she had had a small normal colored macula on her scalp and that it had gradually developed, reaching its largest size during puberty. On physical examination, multiple patches of alopecia were observed in addition to a normal-colored convoluted mass covering the right parietal, right temporal and right occipital regions and small areas of foulsmelling seborrheic dermatitis ( Figures 1A and 1B). Neurological and ophthalmological test results were normal. Family history included no relevant details.X-rays and computerized tomography of the head did not reveal damage to the calvarium. Blood tests and liver, kidney and thyroid function were normal. A cutaneous biopsy revealed melanocytic intradermal nevus with progressive maturation inwards towards the depth of the tissues. Nests and bundles reached the deep dermis and parts of the subcutaneous zone, thereby indicating the intradermal cerebriform subtype (Figures 2 and 3). DisCussionCutis verticis gyrata is a rare disease that is characterized by excess scalp skin, producing folds that are reminiscent of th...

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Cerebriform intradermal nevus. A cause of cutis verticis gyrata

Cited by 41 publications

References 18 publications

Cerebriform intradermal nevus-A rare clinical entity presenting as cutis verticis gyrata

Cerebriform intradermal nevus-A rare clinical entity presenting as cutis verticis gyrata

Four Cases of Lobulated Intradermal Nevus: A Sign of Aging Melanocytic Nevus

Nevo intradérmico cerebriforme como causa de Cutis verticis gyrata

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