Cerebriform Intradermal Nevus

Tabata, Hideyuki; Yamakage, Akio; Yamazaki, Soji

doi:10.1111/j.1365-4362.1995.tb01092.x

Cited by 19 publications

(26 citation statements)

References 4 publications

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“…Our patient was female and had mild occasional itching and also alopecia confined to the nevus since birth. Unlike the reports in the literature [6,11,12], our patient had limited convolutions with a major part of the surface of the scalp being plain. And its extension on the face involving half of the upper cheek was unusual in this case.…”

Section: Discussioncontrasting

confidence: 48%

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Cerebriform intradermal nevus-A rare clinical entity presenting as cutis verticis gyrata

Kudligi¹,

Kuntoji²,

Bhagwat³

et al. 2017

Our Dermatol Online

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Section: Discussioncontrasting

confidence: 48%

“…It is a nodular nevus cerebriform on its surface and is present in the dermis on histopathology [6,7]. Hammond and Ransom first described a Cerebriform nevus resembling cutis verticis gyrata in 1937 [8].…”

Section: Discussionmentioning

confidence: 99%

Cerebriform intradermal nevus-A rare clinical entity presenting as cutis verticis gyrata

Kudligi¹,

Kuntoji²,

Bhagwat³

et al. 2017

Our Dermatol Online

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“…The mechanism of the cerebriform appearance of the cerebriform intradermal nevi is not clear. It is thought to be due to changes in epidermis or multifocal hyperplasia of nevus cells [9]. It is usually seen as an assymetrical skin coloured or slightly pigmented tumor, usually localized on the parietal and occipital regions of scalp.…”

Section: Discussionmentioning

confidence: 99%

“…It usually occurs at birth or in the first year of life and it is more common in women [8][9][10]. The mechanism of the cerebriform appearance of the cerebriform intradermal nevi is not clear.…”

Section: Discussionmentioning

confidence: 99%

Cutis verticis gyrata secondary to cerebriform intradermal nevus

Er¹,

Çakmak²,

Kayaçetin³

et al. 2016

Our Dermatol Online

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“…10 Furthermore, although rare, the brain-like lesions can affect other areas and cases have been described where the neck and scrotum were involved as has a case where a malignant peripheral melanoma was associated with a giant melanocytic intradermal nevus. 11,12,13 With relation to size, CIN can vary from 2 x 3 cm to 22.5 x 25 cm 7,14 Diagnosis of CIN is based on clinical findings and confirmed by histopathology. 7 Characteristics of a positive histopathological result are: nevocytes arranged intradermally with a minimal junctional component, possibly affecting superficial parts of the hypodermis; adjacent structures enveloped by nevocytes; loss of the typical arrangement of nests in stretches; a prevalence of type C nevus cells with large areas of neuroid differentiation; irregular arrangement and distribution of intracellular melanin pigment and perivascular nevocyte aggregation.…”

Section: Traumamentioning

confidence: 99%

Nevo intradérmico cerebriforme como causa de Cutis verticis gyrata

Filho¹,

Darrigo

Avelleira

et al. 2010

Rev. Assoc. Med. Bras.

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Cerebriform intradermal nevus as a Cause of cutis verticis gyrata 639Rev Assoc Med Bras 2010; 56(6): Cutis verticis gyrata (CVG) is a rare disease that is characterized by excess scalp skin, producing thick folds that form creases and ridges similar in appearance to the whorls of the cerebral cortex. It was first described in the literature by Robert in 1843 and the name cutis verticis gyrata was proposed by Unna in 1907 and remains the accepted name to date. 1,2 It has an estimated prevalence of one case in every 100,000 men and 0,026 cases for every 100,000 women. 3 It can be an isolated manifestation that is present from birth or it can be part of other syndromes.Cutis verticis gyrata is classified as primary (subdivided into essential and non essential) or secondary. The essential primary form is not associated with neurological or ophthalmological disorders, and only the folds on the scalp mimicking the cerebral whorls appear. It appears in puberty and affects more men than women. The non essential primary form affects 0.5% of patients with mental retardation. Cerebral palsy, epilepsy, cataracts and blindness may also be present. 2,4,5,6 The secondary forms of CVG generally occur as a result of inflammatory or neoplastic processes that cause changes to the structure of the scalp. 2,6 One of the rarest forms of secondary CVG is the nevoid form, in which it is melanocytic intradermal nevi that cause the cutaneous hypertrophy. This condition is known as cerebriform intradermal nevus (CIN) and was first linked with CVG in 1937 by Hammond and Ransom. 7 Patients affected by CIN have normal intelligence and are free from other local or systemic diseases.The objective of this paper is to describe a rare case of cerebriform intradermal nevus, discussing its histopathological and clinical features. CaseA white female patient, 43 years old, presented at the Instituto de Dermatologia Professor Azulay with large dimension lesions on the scalp. She stated that at birth she had had a small normal colored macula on her scalp and that it had gradually developed, reaching its largest size during puberty. On physical examination, multiple patches of alopecia were observed in addition to a normal-colored convoluted mass covering the right parietal, right temporal and right occipital regions and small areas of foulsmelling seborrheic dermatitis ( Figures 1A and 1B). Neurological and ophthalmological test results were normal. Family history included no relevant details.X-rays and computerized tomography of the head did not reveal damage to the calvarium. Blood tests and liver, kidney and thyroid function were normal. A cutaneous biopsy revealed melanocytic intradermal nevus with progressive maturation inwards towards the depth of the tissues. Nests and bundles reached the deep dermis and parts of the subcutaneous zone, thereby indicating the intradermal cerebriform subtype (Figures 2 and 3). DisCussionCutis verticis gyrata is a rare disease that is characterized by excess scalp skin, producing folds that are reminiscent of th...

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Cerebriform Intradermal Nevus

Cited by 19 publications

References 4 publications

Cerebriform intradermal nevus-A rare clinical entity presenting as cutis verticis gyrata

Cerebriform intradermal nevus-A rare clinical entity presenting as cutis verticis gyrata

Cutis verticis gyrata secondary to cerebriform intradermal nevus

Nevo intradérmico cerebriforme como causa de Cutis verticis gyrata

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