Cerebroprotective Effect of Date Seed Extract (Phoenix dactylifera) on Focal Cerebral Ischemia in Male Rats

Kalantarip, T.P.; Asadi-Shek, M.; Basiri, Mohsen; Najar, Asma

doi:10.3923/jbs.2012.180.185

Cited by 28 publications

(21 citation statements)

References 11 publications

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“…While date palm is reported to be used in headache, recent study suggests that the fruits have cerebroprotective activity in mice suffering from cerebral ischemia (Kalantaripour et al 2012). It was also found to exhibit neuroprotective activity in mice with ischemia induced bilateral common carotid artery occlusion (Pujari et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera)

Sheikh

Zihad

Sifat

et al. 2016

Orient Pharm Exp Med

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In addition to the rich nutritional value, date palm is also used in various ethnobotanical practices for the treatment of various disease conditions. Present investigation was undertaken to examine the neuropharmacological and antinociceptive effect of the ethanol extract of three date cultivars growing in Saudi Arabia, namely Ajwah, Safawy and Sukkari. Neuropharmacological effect was observed by pentobarbitone induced sleeping time, open field, and hole board test. Antinociceptive activity was tested by acetic acid induced writhing and hot plate test. The date extracts were also subjected to HPLC analysis to detect the presence of common bioactive polyphenols. All the three date extracts extended the pentobarbitone induced sleeping time, reduced locomotor activity in open field test and reduced exploratory behaviour in hole board test in mice. The extracts also reduced acetic acid induced writhing and delayed response time in hot plate test. The activities were stronger for Ajwah than the other two date cultivars. HPLC analysis indicated the presence of trans-ferulic acid in all three cultivars, while (+)-catechin and (−)-epicatechin only in Ajwah and Safawy. The observed neuropharmacological and analgesic activity could be partly due to the presence of (+)-catechin, (−)-epicatechin and trans-ferulic acid, three important plant polyphenols well known for their neuroprotective activity and their ability to exert antioxidant activity on brain cells. Present investigation also supports the ethnobotanical use of date palm to provide ameliorating effects in pain and CNS disorders.Electronic supplementary materialThe online version of this article (doi:10.1007/s13596-016-0239-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera)

Sheikh

Zihad

Sifat

et al. 2016

Orient Pharm Exp Med

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“…This creates the impression that different altered mechanisms may be involved that the DFE could be having an antioxidant and neuroprotective effect [17, 21, 58]. Some of the established neuroprotective constitituents of DFE are as follows: melatonin, a potent antioxidant and free radical scavenger [59]; Vitamin C, an accepted antioxidant agent [60]; phenolic compounds which are contained in cinnamic acids and distinctive flavonoids with strong antioxidant effects [19]; magnesium, an antagonist of NMDA receptors [61]; Vitamin B 3 , a water-soluble vitamin with neuroprotective properties [62]; manganese, a free radical scavenger; and selenium, an antioxidant factor with synergic effects with vitamin C [63].…”

Section: Discussionmentioning

confidence: 99%

“…DFEs might be interesting since they have been recently identified as promising neuroprotective agents in several models of neurodegeneration [17]. Recent findings suggest that antioxidant agents might exert neuroprotective effects and may be promising in therapy.…”

Section: Introductionmentioning

confidence: 99%

“…According to recent studies, by Asadi-Shekaari et al and Panahi et al, DFE significantly inhibited neuronal damage induced by cerebral ischemia [17, 27]. Also they resulted that the effectiveness of DFE in focal cerebral ischemia is most probably is due to its antioxidant property [17].…”

Section: Introductionmentioning

confidence: 99%

“…Also they resulted that the effectiveness of DFE in focal cerebral ischemia is most probably is due to its antioxidant property [17]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Date Fruit Extract Is a Neuroprotective Agent in Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats: A Multimodal Analysis

Zangiabadi

Asadi-Shekaari

Sheibani

et al. 2011

Oxidative Medicine and Cellular Longevity

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Background. To study the effects of an aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) diet on diabetic polyneuropathy (DPN) in streptozotocin- (STZ-) induced diabetic rats. Methods. The effects of a date fruit extract (DFE) diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with a nondiabetic control group, diabetic control group (sham), and vehicle group with respect to the following parameters: open field behavioral test, motor nerve conduction velocity (MNCV), and morphological observations. Results. In the model of STZ-induced of diabetic neuropathy, chronic treatment for 6 weeks with DFE counteracted the impairment of the explorative activity of the rats in an open field behavioral test and of the conduction velocity of the sciatic nerve (MNCV). In addition, pretreatment with DFE significantly reversed each nerve diameter reduction in diabetic rats. Conclusion. DFE treatment shows efficacy for preventing diabetic deterioration and for improving pathological parameters of diabetic neuropathy in rats, as compared with control groups.

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Date palm spathe extract reverses chronic stress‐induced changes in dendritic arborization in the amygdala and impairment of hippocampal long‐term potentiation

Hadipour

Meftahi

Jahromi

2023

Synapse

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Chronic restraint stress induces anxiety-like behaviors and emotional abnormalities via an alteration of synaptic remodeling in the amygdala and the hippocampus. Given that the date palm spathe has been shown to have neuroprotective effects on different experimental models, this study aimed to address whether the date palm spathe extract (hydroalcoholic extract of date palm spathe [HEDPP]) can reduce chronic restraint stress-induced behavioral, electrophysiological, and morphological changes in the rat model. Thirty-two male Wistar rats (weight 200-220 g) were randomly divided into control, stress, HEDPP, and stress + HEDPP for 14 days. Animals were submitted to restraint stress for 2 h per day for 14 consecutive days. The animals of the HEDPP and stress + HEDPP groups were supplemented with HEDPP (125 mg/kg) during these 14 days, 30 min before being placed in the restraint stress tube. We used passive avoidance, open-field test, and field potential recording to assess emotional memory, anxiety-like behavioral and long-term potentiation in the CA1 region of the hippocampus, respectively. Moreover, Golgi-Cox staining was used to investigate the amygdala neuron dendritic arborization. Results showed that stress induction was associated with behavioral changes (anxiety-like behavioral and emotional memory impairment), and the administration of HEDPP effectively normalized these deficits.HEDPP remarkably amplified the slope and amplitude of mean-field excitatory postsynaptic potentials (fEPSPs) in the CA1 area of the hippocampus in stressed rats. Chronic restraint stress significantly decreased the dendritic arborization in the central and basolateral nucleus of the amygdala neuron. HEDPP suppressed this stress effect in the central nucleus of the amygdala. Our findings indicated that HEDPP administration improves stress-induced learning impairment and memory and anxiety-like behaviors by preventing adverse effects on synaptic plasticity in the hippocampus and amygdala.

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Cerebroprotective Effect of Date Seed Extract (Phoenix dactylifera) on Focal Cerebral Ischemia in Male Rats

Cited by 28 publications

References 11 publications

Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera)

Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera)

Date Fruit Extract Is a Neuroprotective Agent in Diabetic Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats: A Multimodal Analysis

Date palm spathe extract reverses chronic stress‐induced changes in dendritic arborization in the amygdala and impairment of hippocampal long‐term potentiation

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