Cerebrospinal Fluid Analysis in Central Nervous System Cancer

Schold, S. Clifford; Bullard, Dennis E.

doi:10.1007/978-1-4684-1039-6_38

Cited by 3 publications

(3 citation statements)

References 66 publications

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“…Elevation of CSF p-glucuronidase activity was found in 27 of 28 patients with proven meningeal neoplasmic dissemination and in 12 of 14 patients with diffuse meningeal lymphoma [80]. As treatment is instituted the level parallels or precedes the clinical course [78].…”

Section: Othersmentioning

confidence: 99%

“…~-Glucuronidase concentration increases in the CSF if malignant tumours are adjacent to the ventricular space and in leptomeningeal metastases from breast or lung carcinoma or malignant melanoma [78,91]. Elevation of CSF p-glucuronidase activity was found in 27 of 28 patients with proven meningeal neoplasmic dissemination and in 12 of 14 patients with diffuse meningeal lymphoma [80].…”

Section: Othersmentioning

confidence: 99%

“…CEA is usually undetectable in CSF. Levels in CSF have been reported to be increased in some brain metastases and determinations may aid in patient follow-up [46,78]. As a serum marker for colorectal carcinomas, CEA gives false-positive results in up to 20% of cases [38].…”

Section: Brain Tumours and Metastasesmentioning

confidence: 99%

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Malignancy markers in the cerebrospinal fluid

Koskiniemi

1988

Eur J Pediatr

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The specificity and sensitivity of malignancy marker determinations in cerebrospinal fluid (CSF) are often insufficient. Even at the subclinical stage of the disease the marker should be present. The effect of therapy should be monitored and relapses noted. Thus high standards of methodology are required. There are many substances that may indicate a malignant process in the central nervous system. However, there are many pitfalls in their determination. Malignant cells may occur in CSF via processes involving leptomeningeal structures such as metastases and leukaemia, but primary brain tumours seldom show cells in CSF. Human chorionic gonadotrophin and alpha-fetoprotein determinations assist in the early detection of cerebral germ cell tumours and of relapses, even in the subclinical stage. Desmosterol may aid in the diagnosis of medulloblastomas and malignant gliomas and in monitoring therapy. Putrescine levels are elevated in CSF of patients with medulloblastoma and correlate with the clinical state, and serial analyses may reveal relapses. Fibronectin, when determined in CSF at the time of diagnosis, appears to be of great significance for the prognosis of acute lymphoblastic leukaemia. Ferritin and beta-2-microglobulin may help in some well-defined conditions. Brain-specific proteins and antibodies to them are non-specific markers whereas tumour-specific antigens and growth factors may be more significant.

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Section: Othersmentioning

confidence: 99%

Section: Othersmentioning

confidence: 99%