2023
DOI: 10.1002/exp.20230029
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Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system

Yaqiong Dong,
Ting Xu,
Lan Yuan
et al.

Abstract: The glymphatic system plays a key role in the clearance of waste from the parenchyma, and its dysfunction has been associated with the pathogenesis of Alzheimer's disease (AD). However, questions remain regarding its complete mechanisms. Here, we report that efflux of cerebrospinal fluid (CSF)/interstitial fluid (ISF) solutes occurs through a triphasic process that cannot be explained by the current model, but rather hints at the possibility of other, previously undiscovered routes from paravenous spaces to th… Show more

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