Cerebrospinal fluid protein biomarkers in Parkinson's disease

Faizan, Mohd; Sachan, Nidhi; Verma, Oyashvi; Sarkar, Alika; Rawat, Neeraj; Pratap Singh, Mahendra

doi:10.1016/j.cca.2024.117848

Clinica Chimica Acta

2024

DOI: 10.1016/j.cca.2024.117848

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Cerebrospinal fluid protein biomarkers in Parkinson's disease

Mohd Faizan,

Nidhi Sachan,

Oyashvi Verma

et al.

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2024

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Cited by 2 publications

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Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease

Kim,

Hwang,

George

et al. 2024

IJMS

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Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. Recent studies have highlighted the significant role of cerebrospinal fluid (CSF) in reflecting pathophysiological PD brain conditions by analyzing the components of CSF. Based on the published literature, we created a single network with altered metabolites in the CSF of patients with PD. We analyzed biological functions related to the transmembrane of mitochondria, respiration of mitochondria, neurodegeneration, and PD using a bioinformatics tool. As the proteome reflects phenotypes, we collected proteome data based on published papers, and the biological function of the single network showed similarities with that of the metabolomic network. Then, we analyzed the single network of integrated metabolome and proteome. In silico predictions based on the single network with integrated metabolomics and proteomics showed that neurodegeneration and PD were predicted to be activated. In contrast, mitochondrial transmembrane activity and respiration were predicted to be suppressed in the CSF of patients with PD. This review underscores the importance of integrated omics analyses in deciphering PD’s complex biochemical networks underlying neurodegeneration.

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Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease

Kim,

Hwang,

George

et al. 2024

IJMS

View full text Add to dashboard Cite

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Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease

Hwang,

Kim,

George

et al. 2024

IJMS

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by alpha-synuclein aggregation into Lewy bodies in the neurons. Cerebrospinal fluid (CSF) is considered the most suited source for investigating PD pathogenesis and identifying biomarkers. While microRNA (miRNA) profiling can aid in the investigation of post-transcriptional regulation in neurodegenerative diseases, information on miRNAs in the CSF of patients with PD remains limited. This review combines miRNA analysis with proteomic profiling to explore the collective impact of CSF miRNAs on the neurodegenerative mechanisms in PD. We constructed separate networks for altered miRNAs and proteomes using a bioinformatics method. Altered miRNAs were poorly linked to biological functions owing to limited information; however, changes in protein expression were strongly associated with biological functions. Subsequently, the networks were integrated for further analysis. In silico prediction from the integrated network revealed relationships between miRNAs and proteins, highlighting increased reactive oxygen species generation, neuronal loss, and neurodegeneration and suppressed ATP synthesis, mitochondrial function, and neurotransmitter release in PD. The approach suggests the potential of miRNAs as biomarkers for critical mechanisms underlying PD. The combined strategy could enhance our understanding of the complex biochemical networks of miRNAs in PD and support the development of diagnostic and therapeutic strategies for precision medicine.

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Cerebrospinal fluid protein biomarkers in Parkinson's disease

Cited by 2 publications

References 116 publications

Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease

Integrative Metabolome and Proteome Analysis of Cerebrospinal Fluid in Parkinson’s Disease

Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease

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