Cerium dioxide nanoparticles modulate antioxidant defences and change vascular response in the human saphenous vein

Guerra-Ojeda, Sol; Marchio, Patricia; Rueda, Cristina; Suarez, Andrea; Garcı́a, Hermenegildo; Víctor, Víctor M.; Juez, Marina; Martín-González, Martín; Vila, José M.; Mauricio, María Dolores

doi:10.1016/j.freeradbiomed.2022.11.012

Cited by 5 publications

(2 citation statements)

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“…In a recent study, Guerra-Ojeda et al [121] demonstrated that CeO 2 NPs increase the expression of both SOD isoforms, which increases the bioavailability of NO through the reduction of O − 2 . Additionally, CeO 2 NPs raise the expression of ACE2 in the human saphenous vein, which could explain why the contractile effect of angiotensin II is reduced when these nanoparticles are present.…”

Section: Cerium Oxide Nanoparticlesmentioning

confidence: 99%

“…This potent endothelium-dependent vasodilator, bradykinin, is also a contractile agonist in nonvascular smooth muscle and is related to edema, inflammation, and the pain mechanism, despite the initial impression that the nanoparticles have a negative effect by reducing the vascular response to bradykinin. Thus, in this context, CeO 2 NPs reduced the response to bradykinin, which may be advantageous for pain or inflammation relief [121].…”

Section: Cerium Oxide Nanoparticlesmentioning

confidence: 99%

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Metal-Based Nanoparticles for Cardiovascular Diseases

Scafa Udriște,

Burdușel,

Niculescu

et al. 2024

IJMS

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Globally, cardiovascular diseases (CVDs) are the leading cause of death and disability. While there are many therapeutic alternatives available for the management of CVDs, the majority of classic therapeutic strategies were found to be ineffective at stopping or significantly/additionally slowing the progression of these diseases, or they had unfavorable side effects. Numerous metal-based nanoparticles (NPs) have been created to overcome these limitations, demonstrating encouraging possibilities in the treatment of CVDs due to advancements in nanotechnology. Metallic nanomaterials, including gold, silver, and iron, come in various shapes, sizes, and geometries. Metallic NPs are generally smaller and have more specialized physical, chemical, and biological properties. Metal-based NPs may come in various forms, such as nanoshells, nanorods, and nanospheres, and they have been studied the most. Massive potential applications for these metal nanomaterial structures include supporting molecular imaging, serving as drug delivery systems, enhancing radiation-based anticancer therapy, supplying photothermal transforming effects for thermal therapy, and being compounds with bactericidal, fungicidal, and antiviral qualities that may be helpful for cardiovascular diseases. In this context, the present paper aims to review the applications of relevant metal and metal oxide nanoparticles in CVDs, creating an up-to-date framework that aids researchers in developing more efficient treatment strategies.

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Section: Cerium Oxide Nanoparticlesmentioning

confidence: 99%

Section: Cerium Oxide Nanoparticlesmentioning

confidence: 99%