Cerium oxide nanoparticles attenuate the renal injury induced by cadmium chloride via improvement of the NBN and Nrf2 gene expressions in rats

Bashandy, M. M.; Saeed, Hanan E.; Ahmed, Walaa M.S.; Ibrahim, Marwa A.; Shehata, Olfat

doi:10.1093/toxres/tfac009

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…It is involved in the regulation of the expression of antioxidants, such as GST (45). In the absence of Nrf2, liver regeneration is significantly delayed and hepatocyte death is also increased (46). It has been demonstrated that Co and sevoflurane both downregulate Nrf2 (44,46).…”

Section: Discussionmentioning

confidence: 99%

Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia

et al. 2023

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During liver surgery and transplantation, periods of partial or total vascular occlusion are inevitable and result in ischemia-reperfusion (IR) injury. Nanomedicine uses the latest technological advancement, which has emerged from interdisciplinary efforts involving biomedical sciences, physics and engineering to protect and improve human health. Antioxidant nanoparticles are potential therapeutic agents. The present study investigated the effects of cerium oxide (Co) administration and sevoflurane anesthesia on liver tissue with IR injury. A total of 36 rats were randomly divided into control, Co, IR, IR-Sevoflurane (IRS), Co + IR and Co + IRS groups. In the IR, IRS and Co + IRS groups, hepatic IR was induced. Intraperitoneal Co was administered to the Co groups 30 min before ischemia. Sevoflurane was administered to the IRS and Co + IRS groups during IR injury. Liver tissue samples were examined under the light microscope by staining with hematoxylin and eosin. Thiobarbituric acid (TBARS) levels as well as catalase (CAT) and glutathione-S-transferase (GST) enzyme activity were evaluated in liver tissue samples. The IR group had considerably more hydropic degeneration, sinusoidal dilatation and parenchymal neutrophil infiltration than the Co, IRS, Co + IR and Co + IRS groups. CAT and GST enzyme activity were significantly higher in Co and Co + IR groups compared with the IR group. TBARS levels were significantly lower in Co, IRS, Co + IR and Co + IRS groups compared whit those in the IR group. Intraperitoneal injection of Co with sevoflurane decreased oxidative stress and damage to the liver.

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Section: Discussionmentioning

confidence: 99%

Effects of cerium oxide on liver tissue in liver ischemia‑reperfusion injury in rats undergoing sevoflurane anesthesia

et al. 2023

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“…CeO 2 NPs ameliorated nephrotoxicity by reversing the downregulation of the nuclear factor erythroid 2related factor 2 (Nrf2) gene, which plays a pivotal role in antioxidant response element (ARE)-dependent gene expression. 65 In AKI induced by peritonitis, 20 nm CeO 2 NPs counteract ROS, attenuate caspase-3 activation, reduce the loss of F-actin, alleviate renal tubular injury, and ultimately safeguard renal function. 62 Numerous additional metals (such as Ir, Au, Cu, Mo, Ag, Pt, and Zn) 70,75,78,81,82 and metal oxides have also been shown to exhibit catalase activity.…”

Section: Metal and Metal-basedmentioning

confidence: 99%

“…Furthermore, research indicates CeO 2 NPs suppressed the cadmium-induced upregulation of the nibrin (NBN) gene, which is involved in DNA replication and repair processes. CeO 2 NPs ameliorated nephrotoxicity by reversing the downregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) gene, which plays a pivotal role in antioxidant response element (ARE)-dependent gene expression . In AKI induced by peritonitis, 20 nm CeO 2 NPs counteract ROS, attenuate caspase-3 activation, reduce the loss of F-actin, alleviate renal tubular injury, and ultimately safeguard renal function …”

Section: Therapeutic Nanomaterials For Akimentioning

confidence: 99%

Recent Advances in Nanomaterials for the Treatment of Acute Kidney Injury

Ba,

Ye,

Shang

et al. 2024

ACS Appl. Mater. Interfaces

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Acute kidney injury (AKI) is a serious clinical syndrome with high morbidity, elevated mortality, and poor prognosis, commonly considered a “sword of Damocles” for hospitalized patients, especially those in intensive care units. Oxidative stress, inflammation, and apoptosis, caused by the excessive production of reactive oxygen species (ROS), play a key role in AKI progression. Hence, the investigation of effective and safe antioxidants and inflammatory regulators to scavenge overexpressed ROS and regulate excessive inflammation has become a promising therapeutic option. However, the unique physiological structure and complex pathological alterations in the kidneys render traditional therapies ineffective, impeding the residence and efficacy of most antioxidant and anti-inflammatory small molecule drugs within the renal milieu. Recently, nanotherapeutic interventions have emerged as a promising and prospective strategy for AKI, overcoming traditional treatment dilemmas through alterations in size, shape, charge, and surface modifications. This Review succinctly summarizes the latest advancements in nanotherapeutic approaches for AKI, encompassing nanozymes, ROS scavenger nanomaterials, MSC-EVs, and nanomaterials loaded with antioxidants and inflammatory regulator. Following this, strategies aimed at enhancing biocompatibility and kidney targeting are introduced. Furthermore, a brief discussion on the current challenges and future prospects in this research field is presented, providing a comprehensive overview of the evolving landscape of nanotherapeutic interventions for AKI.

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“…55 CeO 2 NPs have good biocompatibility and can prevent cadmium-induced kidney injury by clearing ROS, downregulating apoptotic genes, and upregulating antioxidation-related genes. 56…”

Section: Application Of Antioxidant Enzymes In Akimentioning

confidence: 99%