Cerium Oxide Nanoparticles‐Based Optical Biosensors for Biomedical Applications

Wang, Qiyue; Wang, Bingzhe; Shi, Dao; Li, Fangyuan; Ling, Daishun

doi:10.1002/adsr.202200065

Cited by 8 publications

(1 citation statement)

References 58 publications

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“…In addition to the examples mentioned earlier, numerous other enzyme reactions can be used in biosensing applications. For instance, enzymes, such as peroxidase and catalase, can be used to catalyze the oxidation of various substrates using H 2 O 2 as a co-substrate, producing detectable signals, such as color changes or oxygen gas bubbles [ 50 ]. Similarly, enzymes, such as alcohol dehydrogenase and lactate dehydrogenase, can be used to catalyze redox reactions with coenzymes, such as NAD+ and NADH, which can be measured electrochemically or optically [ 51 ].…”

Section: Components Of Enzymatic Biosensorsmentioning

confidence: 99%

Enzymatic Electrochemical/Fluorescent Nanobiosensor for Detection of Small Chemicals

Choi

Yoon

2023

Biosensors

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The detection of small molecules has attracted enormous interest in various fields, including the chemical, biological, and healthcare fields. In order to achieve such detection with high accuracy, up to now, various types of biosensors have been developed. Among those biosensors, enzymatic biosensors have shown excellent sensing performances via their highly specific enzymatic reactions with small chemical molecules. As techniques used to implement the sensing function of such enzymatic biosensors, electrochemical and fluorescence techniques have been mostly used for the detection of small molecules because of their advantages. In addition, through the incorporation of nanotechnologies, the detection property of each technique-based enzymatic nanobiosensors can be improved to measure harmful or important small molecules accurately. This review provides interdisciplinary information related to developing enzymatic nanobiosensors for small molecule detection, such as widely used enzymes, target small molecules, and electrochemical/fluorescence techniques. We expect that this review will provide a broad perspective and well-organized roadmap to develop novel electrochemical and fluorescent enzymatic nanobiosensors.

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Section: Components Of Enzymatic Biosensorsmentioning

confidence: 99%

Enzymatic Electrochemical/Fluorescent Nanobiosensor for Detection of Small Chemicals

Choi

Yoon

2023

Biosensors

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A Neuronal Signal Sorting and Amplifying Nanosensor for EEG‐Concordant Imaging‐Guided Precision Epilepsy Ablation

Wang,

Cui,

Shi

et al. 2024

Advanced Materials

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Surgery remains an essential treatment for managing drug‐resistant focal epilepsy, but its accessibility and efficacy are limited in patients without distinct structural abnormalities on magnetic resonance imaging (MRI). Potassium ion (K+), a critical marker for seizure‐associated neuronal signaling, shows significant promise for designing sensors targeting hidden epileptic foci. However, existing sensors cannot cross the blood‐brain barrier and lack the ability to specifically enrich and amplify K+ signals in the brain with high temporal and spatial resolution. Here, an intravenously administered neuronal signal sorting and amplifying nanosensor (NSAN) is reported that combines real‐time dynamic reversible K+ fluorescence imaging with high‐resolution structural MRI, enabling electroencephalogram‐concordant imaging of MRI‐negative epileptic foci. Guided by NSANs, minimally invasive surgery is successfully performed in both intrahippocampal kainic acid (KA) epilepsy model with foci confined to the ipsilateral hippocampus, and intraperitoneal KA model where foci are randomly distributed, resulting in sustained seizure control and cognitive improvement. These findings highlight the NSAN as a transformative tool for visualizing hidden epileptic foci, thereby broadening eligibility for minimally invasive and precision surgical intervention.

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