Cerium oxide nanoparticles exhibit minimal cardiac and cytotoxicity in the freshwater fish Catostomus commersonii

Rundle, Amanda; Robertson, Anne B.; Blay, Alexandra M.; Butler, Kathryn M.; Callaghan, Neal I.; Dieni, Christopher A.; MacCormack, Tyson J.

doi:10.1016/j.cbpc.2015.12.007

Cited by 12 publications

(7 citation statements)

References 43 publications

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“…To date, the estimated production of nCeO 2 is around 1000 tons/year and it has become one of the most produced ENPs in the world (Piccino et al, 2012). Upon their release into the aquatic environment, nCeO 2 may provoke adverse effects to various organisms (Rundle et al, 2016;Taylor et al, 2016;Kosak Née Röhder et al, 2018;Wang and Nowack, 2018;Correia et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effects of humic substances on the aqueous stability of cerium dioxide nanoparticles and their toxicity to aquatic organisms

Wang

Zhai

et al. 2021

Science of The Total Environment

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Section: Introductionmentioning

confidence: 99%

Effects of humic substances on the aqueous stability of cerium dioxide nanoparticles and their toxicity to aquatic organisms

Wang

Zhai

et al. 2021

Science of The Total Environment

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“…For instance, n-CeO 2 elicited genotoxic effects in Daphnia magna (García et al, 2011), and growth-inhibitory impacts in Pseudokirchneriella subcapitata (Rodea-Palomares et al, 2010). Besides, its oxidative stress effects in Corophium volutator (Dogra et al, 2016), mild cytotoxic and cardiac toxicity in the white sucker fish (Catostomus commersonii) (Rundle et al, 2016) and immunotoxicity with a high mortality rate of rainbow trout (Oncorhynchus mykiss) (Correia et al, 2019) had been reported.…”

Section: Introductionmentioning

confidence: 99%

The applications of cerium oxide nanoform and its ecotoxicity in the aquatic environment: an updated insight

Naiel

Abdel‐Latif

El‐Hack

et al. 2022

Aquat. Living Resour.

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The widespread usage of nanotechnology in many essential products has raised concerns about the possible release of nanoparticles (NPs) into aquatic habitats. Cerium dioxide (CeO2) has gained the most interest in the worldwide nanotechnology industry of all types of Ce minerals owing to its beneficial uses in a wide range of industry practices such as catalysts, sunscreens, fuel additives, fuel cells, and biomedicine. Besides, it was realized that CeO2 nanoparticles (n-CeO2) have multi-enzyme synthesized properties that create various biological impacts, such as effectively antioxidant towards almost all irritant intracellular reactive oxygen species. Lately, it was discovered that a large amount of n-CeO2 from untreated industrial waste could be released into the aquatic environment and affect all living organisms. In addition, the physical/chemical characteristics, fate, and bioavailability of nanomaterials in the aquatic environment were discovered to be related to the synthesis technique. Thus, there are intended needs in identifying the optimal technique of synthesized CeO2 nanoparticles in order to assess their beneficial use or their potential ecotoxicological impacts on aquatic organisms and humans. Therefore, this review sheds light on the possible threats of n-CeO2 to aquatic creatures as well as its synthesized techniques. Also, it discusses the possible mechanism of n-CeO2 toxicity as well as their potential benefits in the aquaculture industry.

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“…Cerium (Ce) was frequently tested in its nanoparticle form. Cerium oxide nanoparticles (nCeO 2 ) showed elevated plasma cortisol levels in white sucker ( Catostomus commersonii ) after acute in vivo exposure to 1 mg/L nCeO 2 for 25 h. Biomarkers for oxidative, cardiorespiratory, or osmoregulatory stress, however, remained unchanged, suggesting mild toxicity effects outside of the cardiorespiratory system (Rundle et al 2016 ). Heat shock protein 70 ( hsp70 ) gene expression significantly increased after 96 h exposure to Ce 3+ in juvenile rainbow trout (Dubé et al 2019 ) indicating a stress response related to exposure.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of representative mixture of five rare earth elements in juvenile rainbow trout (Oncorhynchus mykiss) juveniles

Hanana

Kleinert

Gagné

2021

Environ Sci Pollut Res

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Rare earth elements (REEs) are contaminants of increasing interest due to intense mining activities for commercial purposes and ultimately released in the environment. We exposed juvenile rainbow trout (Oncorhynchus mykiss) to a representative mixture of the five most abundant REEs for 96 h at concentrations similar found in lakes contaminated by mining activities at 0.1, 1, 10, and 100X whereas the 1x mixture contained cerium (Ce, 280 μg/L), lanthanum (La, 140 μg/L), neodymium (Nd, 120 μg/L), praseodymium (Pr, 28 μg/L), and samarium (Sm, 23 μg/L). We investigated the expression of 14 genes involved in oxidative stress, DNA repair, tissue growth/proliferation, protein chaperoning, xenobiotic biotransformation, and ammonia metabolism in the liver. In addition, DNA damage, oxidative stress (lipid peroxidation or LPO), inflammation (cyclooxygenase or COX activity), detoxification mechanisms (glutathione-S-transferase activity or GST), and labile zinc were determined in gills. The data revealed that genes involved in oxidative stress-catalase (cat), heat shock proteins 70 (hsp70), and glutamate dehydrogenase (glud) were upregulated while glutathione S-transferase (gst) and metallothionein (mt) gene expressions were downregulated. The mixture was genotoxic and increased labile Zn in gills of exposed trout. These changes occurred at concentrations 600 times lower than the LC50 for this mixture indicating effects below the 1X concentration. Based on principal component analysis and concentration-dependent reponses, the following sublethal effects were considered the most important/significant: DNA strand breaks (genotoxicity), labile Zn, cat, gst, hsp70, sparc, mt, and glud. These effects of fish juveniles are likely to occur in environments under the influence of mining activities.

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Cerium oxide nanoparticles exhibit minimal cardiac and cytotoxicity in the freshwater fish Catostomus commersonii

Cited by 12 publications

References 43 publications

Effects of humic substances on the aqueous stability of cerium dioxide nanoparticles and their toxicity to aquatic organisms

Effects of humic substances on the aqueous stability of cerium dioxide nanoparticles and their toxicity to aquatic organisms

The applications of cerium oxide nanoform and its ecotoxicity in the aquatic environment: an updated insight

Toxicity of representative mixture of five rare earth elements in juvenile rainbow trout (Oncorhynchus mykiss) juveniles

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