Cervical Cancer Screening

Sawaya, George F.; Huchko, Megan J.

doi:10.1016/j.mcna.2017.03.006

Cited by 31 publications

(24 citation statements)

References 43 publications

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“…Studies have revealed that human papillomavirus (HPV) infection is associated with progression of CINII and CINIII, and invasive cancer. Especially, patients with infection of HPV strains 16 and 18 cause about 70% of CINII, CINIII, and cervical cancer 3, 5, 6. Thus, HPV vaccine is useful for prevention of the cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Awareness of surgical smoke hazards and enhancement of surgical smoke prevention among the gynecologists

et al. 2019

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Surgical smoke is the gaseous by-product produced by heat generating devices in various surgical operations including laser conization and loop electrosurgical procedures that often are performed by gynecologists. Surgical smoke contains chemicals, blood and tissue particles, bacteria, and viruses, which has been shown to exhibit potential risks for surgeons, nurses, anesthesiologists, and technicians in the operation room due to long term exposure of smoke. In this review, we describe the detailed information of the components of surgical smoke. Moreover, we highlight the effects of surgical smoke on carcinogenesis, mutagenesis, and infection in gynecologists. Furthermore, we discussed how to prevent the surgical smoke via using high-filtration masks and smoke evacuation systems as well as legal guidelines for protection measures among the gynecologists.

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Section: Introductionmentioning

confidence: 99%

Awareness of surgical smoke hazards and enhancement of surgical smoke prevention among the gynecologists

et al. 2019

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“…Epidemiological data combined with laboratory studies have identified persistent infection with high-risk (HR)-human papilloma virus (HPV) as a necessary condition for cervical intra-epithelial neoplasia (CIN) and cervical cancer [2]. Recently, with the development of HPV detection technology and improvements in screening strategies, clinicians have succeeded in increasing the prevention of cervical cancer [3, 4]. Currently, HPV detection has emerged as the primary screening method for cervical lesions in many countries [5, 6].…”

Section: Introductionmentioning

confidence: 99%

The value of cytokine levels in triage and risk prediction for women with persistent high-risk human papilloma virus infection of the cervix

Li¹,

Zhang

Zhao

et al. 2019

Infect Agents Cancer

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Background Cervical cancer is a common cancer among women worldwide and is closely related to high-risk human papillomavirus infection (HR-HPV). The immune microenvironment is thought to play an essential role in viral infection and cancer development; however, this relationship remains controversial. Cytokines are an important part of the immune system. Therefore, in this study, we explored changes in cervical cytokine levels of women with persistent HR-HPV infection and determined the value of cytokine detection in assessing cervical lesions. Methods We enrolled 146 patients; 117 had long-term high-risk (HR) HPV infection (> 6 months), and 29 were HPV-negative with previous HR-HPV infection. According to histopathological examination, 43 patients were diagnosed with cervicitis; 35, with low-grade squamous intraepithelial lesions (LSILs); and 39, with high-grade squamous intraepithelial lesions (HSILs). Cytokine levels in vaginal fluid were examined using cytometric bead array, and the values of interleukin (IL)-6 and IL-2 levels were converted to a cytokine score. The performance of the cytokine score for diagnosis and risk assessment was compared with that of ThinPrep cytology tests (TCTs). Results Disease severity was positively associated with IL-6 levels and inversely related to IL-2 levels. The area under the curve (AUC) was higher for the cytokine score including IL-6 and IL-2 than for TCTs for HSILs. Comparisons of the sensitivity, specificity, Youden index, and positive and negative predictive values for HSILs demonstrated that the cytokine score was better than TCT. HPV-positive patients with high cytokine scores showed increased risk of developing HSIL within 3 years. The hazard ratio for the cytokine score was 3.12; thus, the risk of developing HSIL was related to the cytokine score. Conclusions The cytokine score increased with the severity of cervical lesions and could distinguish more patients from HPV-positive women and predict the risk of disease progression.

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“…This may result in disadvantage for some female patients, especially in rural areas where there may not be adequate access to female physicians for cervical cancer screening. Given the clinical consequences of suboptimal cervical cancer screening, 15 this may be a significant health access issue.…”

Section: Discussionmentioning

confidence: 99%

Gender differences in Australian general practice trainees performing procedures related to women’s reproductive health: A cross-sectional analysis

Aghajafari¹,

Tapley²,

Driel³

et al. 2018

Aust J Gen Pract

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Cervical Cancer Screening

Cited by 31 publications

References 43 publications

Awareness of surgical smoke hazards and enhancement of surgical smoke prevention among the gynecologists

Awareness of surgical smoke hazards and enhancement of surgical smoke prevention among the gynecologists

The value of cytokine levels in triage and risk prediction for women with persistent high-risk human papilloma virus infection of the cervix

Gender differences in Australian general practice trainees performing procedures related to women’s reproductive health: A cross-sectional analysis

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