Cervical mucus status can be accurately estimated by transvaginal ultrasound during fertility evaluation

Wolman, Igal; Gal, Tamar Birenbaum; Jaffa, Ariel J.

doi:10.1016/j.fertnstert.2009.01.077

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…The ovulatory CM provides, in fact, a defense for the sperm against the hostile acidic vaginal secretions, fulfills its energy demands, filters from the ejaculate the morphologically abnormal and dysmotile sperms and provides conditions for sperm capacitation. 1 Moreover the CM represents an inhibitory microenvironment for sperm propagation during the non-ovulatory phases of the cycle. However, the function of cervical mucus is not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

Proteomic characterization of the qualitative and quantitative differences in cervical mucus composition during the menstrual cycle

et al. 2015

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The chemical composition of the cervical mucus (CM), its physical characteristics and the volume of secretion change cyclically throughout the menstrual cycle. The aim of this study was to identify the constitutive protein composition of CM of fertile women and the changes in the CM proteome throughout the menstrual cycle. Five fertile women who had a term delivery within 1 year before the study were enrolled. Proteomic analysis was performed using an Ultimate 3000 Nano/Micro-HPLC apparatus equipped with an FLM-3000-Flow manager module and coupled with an LTQ Orbitrap XL hybrid mass spectrometer; bioinformatic software was used for functional and quantitative analysis. 59, 81 and 43 proteins (mean) were respectively identified in the pre-ovulatory, ovulatory and post-ovulatory samples. 38 common proteins were identified. 42, 38 and 17 exclusive proteins were respectively identified in pre-ovulatory, ovulatory and post-ovulatory CM. The main part of CM constituents has a catalytic activity, which is mainly related to hydrolase activity. The label-free quantitative analysis of the common proteins revealed a significant reduction in the protein abundance index for antileukoproteinase, after the ovulation, and a peak of haptoglobin at ovulation. This is the first application of high-resolution MS-based proteomics for the identification of protein constituents of CM. This approach may contribute to the identification of putative biomarkers of the female reproductive tract.

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Section: Introductionmentioning

confidence: 99%

Proteomic characterization of the qualitative and quantitative differences in cervical mucus composition during the menstrual cycle

et al. 2015

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“…Examinations of the cervical mucus to determine its quantity and physical characteristics are used to predict the timing of ovulation in women [25]; however, this method has not yet been extensively explored in animal reproduction. In the present study, the first type of cervical mucus observed was crystalline.…”

Section: Parametermentioning

confidence: 99%

Evaluation of cervical mucus and reproductive efficiency of seasonally anovular dairy goats after short-term progestagen-based estrous induction protocols with different gonadotropins

Fonseca

Souza-Fabjan

Oliveira

et al. 2017

Reproductive Biology

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The use of three different gonadotropins was tested for estrous induction in dairy goats during the non-breeding season. All does received an injection of 30 μg of d-cloprostenol and intravaginal sponges containing 60mg of medroxyprogesterone acetate (MAP) for 6 d plus 20 IU of porcine FSH (pFSH), 200 IU of eCG or 250 IU of hCG 24h before sponge removal. In Experiment 1 (n=24), ovarian ultrasound parameters were recorded and cervical mucus was evaluated daily for 5 d after sponge removal or until ovulation. In Experiment 2 (n=80), reproductive efficiency of artificially inseminated or naturally mated does was assessed. The mean interval from sponge removal to ovulation (73.5±23.7 h), number of ovulations (1.6±0.7) and ovulatory follicle diameter (7.2±0.8 mm) did not vary (P >0.05) among the three groups. At ovulation, cervical mucus had crystalline-striated to striated (22.2%), striated to striated-caseous (72.2%) and striated-caseous to caseous (5.6%) appearance. The largest follicle diameter was greater (P <0.05) in does with crystalline (6.7±1.4 mm), crystalline-striated (7.2±1.1 mm) or striated (7.3±1.3 mm) mucus than in those with striated-caseous (5.3±1.4 mm) or caseous (4.5±1.1 mm) mucus. Percentage of animals exhibiting estrus (92.5%) and conception rate (60.8%) were similar (P >0.05) among the three gonadotropins groups. Results of this study support the use of eCG (200 IU), hCG (250 IU) and pFSH (20 IU) for the estrous induction protocols in dairy goats during the non-breeding season. Cervical mucus evaluation can be used as an additional method to determine the optimal time for artificial insemination in goats.

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“…The antiestrogenic effect on the cervical mucus, when present, is expressed by a decreased amount of mucus, which occurs despite the relatively high levels of estrogen in the circulation. Wollman et al [ 31 ] demonstrated that the cervical mucus can be visualized in many patients around the time of ovulation using pelvic ultrasound (see Fig. 18.5 ).…”

Section: Antiestrogenic Effects On the Cervix And Endometriummentioning

confidence: 99%

“…In such instances hCG should be a b Fig. 18.12 ( a ) Cervical canal measurement near ovulation and ( b ) after ovulation (Reprinted from Wolman et al [ 31 ]. With permission from Elsevier) administered to induce ovulation.…”

Section: Treatment Schema and Monitoring Of Clomiphene Citrate Therapymentioning

confidence: 99%

Ultrasound in Follicle Monitoring for Ovulation Induction/IUI

Blankstein

Malepati

Brasch

2013

Ultrasound Imaging in Reproductive Medicine

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Cervical mucus status can be accurately estimated by transvaginal ultrasound during fertility evaluation

Cited by 8 publications

References 7 publications

Proteomic characterization of the qualitative and quantitative differences in cervical mucus composition during the menstrual cycle

Proteomic characterization of the qualitative and quantitative differences in cervical mucus composition during the menstrual cycle

Evaluation of cervical mucus and reproductive efficiency of seasonally anovular dairy goats after short-term progestagen-based estrous induction protocols with different gonadotropins

Ultrasound in Follicle Monitoring for Ovulation Induction/IUI

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