Cervical Paraganglioma Presenting as Thyroid Neoplasia

Kieu, Violet; Yuen, A.K.T.; Tassone, Peter; Hobbs, Chris G.

doi:10.1177/0194599811419229

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…As illustrated by our study, the most important clinical technique for differentiating thyroid paraganglioma from other histologies is IHC. We reviewed the literature finding 48 available case reports (Basu & Viswanathan 2011, Phitayakorn et al 2011, Armstrong et al 2012, Capel 2012, Castelblanco et al 2012, Costinean et al 2012, Evankovich et al 2012, Kieu et al 2012, Mohyuddin et al 2013, Yu et al 2013. Similar to our cases, true thyroid paragangliomas are characterized by immunohistochemical positive staining for chromogranin A (30 of 30 investigated tumors/case), synaptophysin (21/21), S-100 (27/28), and neuron-specific enolase (18/18).…”

Section: Discussionsupporting

confidence: 69%

“…Thyroid paraganglioma is a rare entity with approximately 60 cases that are reported, including our series (LaGuette et al 1997, Yano et al 2007, Ferri et al 2009, González Poggioli et al 2009, Basu & Viswanathan 2011, Phitayakorn et al 2011, Varsavsky et al 2011, Armstrong et al 2012, Capel 2012, Castelblanco et al 2012, Costinean et al 2012, Evankovich et al 2012, Kieu et al 2012, Mohyuddin et al 2013, Yu et al 2013. A major question is whether the rare entity of thyroid paraganglioma is of practical clinical relevance.…”

Section: Discussionmentioning

confidence: 73%

“…Interestingly, two of our paraganglioma patients are males, which is in contrast to the results in the reviewed literature (Basu & Viswanathan 2011, Phitayakorn et al 2011, Armstrong et al 2012, Capel 2012, Castelblanco et al 2012, Costinean et al 2012, Figure 11 Electropherograms of SDHB and SDHA sequence variants identified in cases 1, 3, and 4. Evankovich et al 2012, Kieu et al 2012, Mohyuddin et al 2013, Yu et al 2013.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A registry-based study of thyroid paraganglioma: histological and genetic characteristics

Dobschuetz

Leijon

Schalin‐Jäntti

et al. 2015

Endocrine-Related Cancer

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A registry-based study of thyroid paraganglioma: histological and genetic characteristics

Dobschuetz

Leijon

Schalin‐Jäntti

et al. 2015

Endocrine-Related Cancer

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“…Thyroid paraganglioma (TP) is an uncommon tumor, which may be derived from the inferior laryngeal paraganglia (1). Paraganglioma is a neuroendocrine tumor originating from paraganglia of the autonomic nervous system, which is derived from ectoderm cells (2), whereas the thyroid gland is derived from cells of entodermal origin (3) and thus, it would appear that the development of paraganglioma originating from the thyroid gland is extremely unlikely.…”

Section: Introductionmentioning

confidence: 99%

Primary thyroid paraganglioma mimicking medullary thyroid carcinoma: A case report

Xing

Wang

et al. 2015

Oncology Letters

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Abstract. Primary thyroid paraganglioma (TP) is an uncommon tumor, and in rare cases, this disease tends to mimic medullary thyroid carcinoma (MTC). The present study reports a rare case of primary TP mimicking thyroid carcinoma, accompanied by hyperthyroidism. A 30-year-old female presented with an anterior cervical mass. Pre-operative radiological studies and operative frozen section analysis indicated an atypical MTC. Primary TP was finally diagnosed by pathology and immunohistochemical staining. Laboratory examinations (thyroid hormones tests) and Tc99m emission computed tomography revealed hyperthyroidism. Gene analysis of TP-associated gene mutations was negative. Surgical resection was performed as a curative approach and there is currently no metastasis after 36 months of follow-up. Surgeons must be aware of this disease in order to ensure a correct diagnosis and to prevent them from performing unnecessary procedures. The current study presents a case of primary TP mimicking MTC, discusses the radiographic results and histological characteristics, and provides a review of the associated literature.

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“…Ninety percent of head and neck PGLs are sporadic, while only 10% are hereditary in nature [2]. In literature, cases of PGL mimicking thyroid nodules are rarely encountered [4,5]. In the report, we will present a case of PGL (a carotid body tumor) that we initially evaluated as a thyroid nodule, and then diagnosed as a PGL.…”

Section: Introductionmentioning

confidence: 99%

A Carotid Body Tumor Mimicking a Thyroid Nodule

Baser

2014

J Med Cases

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Paragangliomas (PGLs) are neuroendocrine tumors arising from the extra-adrenal chromaffin tissue of the autonomic nervous system. They are most frequently found in the head and neck, mainly associated with the carotid body, vagus nerve, jugulotympanic paraganglia, and occasionaly, the superior-inferior paraganglia. Paragangliomas are rarely encountered in thyroid as well, and thyroid paragangliomas can be misinterpreted as medullary thyroid carcinomas. However, cases of paragangliomas mimicking thyroid nodules were also reported in literature rarely. In this article, we reported a case first giving an impression of a thyroid nodule, then suggesting the likelihood of a medullary thyroid carcinoma or intrathyroidal paraganglioma via core needle biopsy, but finally was diagnosed as a carotid body tumor.

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Cervical Paraganglioma Presenting as Thyroid Neoplasia

Cited by 5 publications

References 5 publications

A registry-based study of thyroid paraganglioma: histological and genetic characteristics

A registry-based study of thyroid paraganglioma: histological and genetic characteristics

Primary thyroid paraganglioma mimicking medullary thyroid carcinoma: A case report

A Carotid Body Tumor Mimicking a Thyroid Nodule

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