“…Several randomized trials have compared misoprostol and placebo or no therapy for cervical priming before firsttrimester surgical abortion and found that misoprostol increases baseline dilation and facilitates further dilation. These studies analyzed vaginal doses of 100 to 750 mcg [19,61,91,95,96,101,103,105,139,140], oral doses of 400 to 600 mcg [103,104,141] and a sublingual dose of 400 mcg [107,113,142]. Almost all of these studies demonstrated an increased baseline cervical dilatation with misoprostol, and some also found a greater subjective ease of dilation [19,95,104,[140][141][142], lower measured cumulative force with dilation [61,103], shorter procedure time [19,91,95,96,104,107,113] or lower estimated blood loss [103,104,107,113].…”