Cervical spine tenosynovial giant cell tumor involving the atlantoaxial joint in a pediatric patient with medulloblastoma

Tsui, Waylon Wai Chung; Fung, Kwai-Yau; Chan, Pui Kwan Joyce; Yuen, Ming Keung; Kan, Yee Ling Elaine

doi:10.1007/s00256-021-03952-z

Cited by 3 publications

(8 citation statements)

References 22 publications

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“…Involvement of the axial skeleton is rare, with only ~80 cases having been reported in the literature [ 1 , 8 ]. When present in the spine, 52% of lesions are found in the cervical spine while 29% of lesions occur in the lumbar spine and the remaining 17% of lesions are found in the thoracic spine [ 5 ]. Within the cervical spine, lesions of the upper cervical spine (C1/2) are extremely rare, with only 13 cases reported in the literature [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Imaging often lacks specific features for diagnosis [ 5 ]. There is a long list of differential diagnoses for cervical spinal masses, including aneurysmal bone cysts, granulomatous infection, synovial chrondromatosis, rheumatoid arthritis, osteoblastoma, gout, calcium pyrophosphate deposition disease, amyloid arthropathy, inflammatory arthropathy, and metastases [ 5 , 6 , 10 ]. Often, TSGCT is not considered due to its rarity.…”

Section: Discussionmentioning

confidence: 99%

“…They are rarely found in the spine but, when present, are generally found in the lower cervical and lumbar regions [ 4 ]. Lesions of the upper cervical spine (C1/2) are extremely rare, with only 13 cases reported in the literature [ 5 ]. Gross total resection is recommended for all TSGCTs due to their locally aggressive nature and the subsequent risk of joint instability from bone erosion and of neurological deficit from spinal cord compression [ 1 , 2 , 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Lesions of the upper cervical spine (C1/2) are extremely rare, with only 13 cases reported in the literature [ 5 ]. Gross total resection is recommended for all TSGCTs due to their locally aggressive nature and the subsequent risk of joint instability from bone erosion and of neurological deficit from spinal cord compression [ 1 , 2 , 5 – 7 ]. However, in recurrent or inoperable cases, immunotherapy, radiation therapy and radiological surveillance are used [ 2 , 4 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, in recurrent or inoperable cases, immunotherapy, radiation therapy and radiological surveillance are used [ 2 , 4 , 8 ]. 9 of the 13 previous upper cervical cases underwent gross total resection, while 3 were managed conservatively with serial MRI scans and 1 underwent immunotherapy [ 2 , 3 , 5 – 14 ]. This case report includes two patients with TSGCSTs in the cervical spine: one with a lesion between C1/2 and another at C6/7.…”

Section: Introductionmentioning

confidence: 99%

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Tenosynovial giant cell tumours of the upper and lower cervical spine: two case reports

Zhu

Campbell

Sadasivan

2022

Spinal Cord Ser Cases

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Introduction Tenosynovial giant cell tumours (TSGCTs) usually arise from the synovial membranes of tendon sheaths, bursa, and joints. They are rarely found in the spine. Lesions of the upper cervical spine (C1/2) are extremely rare, with only 13 previous cases reported in the literature. Of these, all previous anterior upper cervical cases (C1/2) have been deemed unresectable and have been managed with immunotherapy or radiological surveillance. Case presentation We report two cases of TSGCST in the cervical spine: one with a lesion at C1/2 and another at C6/7. Discussion The location of our C1/2 lesion was unique, allowing for a new endoscopic endonasal tissue biopsy method and a new transoral surgical approach for successful gross total resection. Our C6/7 lesion had a more typical location and was removed via a C6/7 laminectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tenosynovial giant cell tumours of the upper and lower cervical spine: two case reports

Zhu

Campbell

Sadasivan

2022

Spinal Cord Ser Cases

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Giant cell tumor of tendon sheath in the pediatric population – review

Kopcik,

Koberling,

Koper

et al. 2023

Eur J Trans Clin Med

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Surgical treatment of spinal tenosynovial giant cell tumor: Experience from a single center and literature review

et al. 2023

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IntroductionSpinal tenosynovial giant cell tumor (TGCT) is a rare benign primary spinal tumor with aggressive behavior. The treatment strategy and prognosis of spinal TGCT remain unclear. This retrospective study aimed to evaluate the effectiveness of surgical treatment of spinal TGCT.MethodsWe enrolled 18 patients with spinal TGCT who underwent surgical treatment in our hospital between January 2002 and January 2021. Additionally, we reviewed 72 cases of spinal TGCT with surgical treatment reported in the previous literature. Therefore, a total of 90 cases of spinal TGCT were evaluated for their clinical characteristics, surgical details, radiotherapy, and prognosis.ResultsIn terms of the extent of resection, 73 cases (81.1%) underwent gross total resection (GTR), and 17 cases (18.9%) underwent subtotal resection (STR). Regarding the technique of GTR, 12 cases (16.7%) underwent en bloc resection, while 60 cases (83.3%) underwent piecemeal resection. During a median follow-up duration of 36 months (range: 3–528 months), 17.8% (16/90) cases experienced local recurrence/progression. The local recurrence/progression rate in cases that underwent GTR was 8.2% (6/73), which was significantly lower than that in cases with STR (58.8%, 10/17) (p<0.001). The local recurrence/progression rate of en bloc resection was 8.3% (1/12), and that of piecemeal resection was 8.3% (5/60). Twelve cases underwent perioperative adjuvant radiotherapy, and one (8.3%, 1/12) of them showed disease progression during follow-up. Six recurrent/progressive lesions were given radiotherapy and all of them remained stable in the subsequent follow-up. Eight recurrent/progressive lesions were only treated with re-operation without radiotherapy, and half of them (50.0%, 4/8) demonstrated repeated recurrence/progression in the subsequent follow-up.ConclusionSurgical treatment could be effective for spinal TGCT cases, and GTR is the preferred surgical strategy. Piecemeal resection may be appropriate for spinal TGCT cases with an acceptable local recurrence/progression rate. Perioperative adjuvant radiotherapy may reduce the risk of postoperative local recurrence/progression, and radiotherapy plays an important role in the treatment of recurrent/unresectable spinal TGCT lesions.

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Cervical spine tenosynovial giant cell tumor involving the atlantoaxial joint in a pediatric patient with medulloblastoma

Cited by 3 publications

References 22 publications

Tenosynovial giant cell tumours of the upper and lower cervical spine: two case reports

Tenosynovial giant cell tumours of the upper and lower cervical spine: two case reports

Giant cell tumor of tendon sheath in the pediatric population – review

Surgical treatment of spinal tenosynovial giant cell tumor: Experience from a single center and literature review

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