Cervical Spondylodiscitis Caused by Candida Albicans in Non-Immunocompromised Patient

Moon, Hyung Bae; Kim, Jae-Hoon; Moon, Byung Gwan; Kim, Joo Seung

doi:10.3340/jkns.2008.43.1.45

Cited by 16 publications

(26 citation statements)

References 12 publications

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“…Candida species are normal flora that inhabit the skin and mucous membrane of human host 8. Invasive fungal infections caused by Candida species have increased significantly over the past two decades 10…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the widespread use of antibiotics, central venous catheters, intravenous drugs and immunosuppressive chemotherapy have increased virulent infection by Candida species in immunocompromised inviduals 8. Patients cronically ill and malnourished, in particular if they are receiving total parenteral nutrition or have had gastrointestinal injury or surgery (gastrointestinal tract perforations and anastomotic leaks), with HIV infection and injecting drug abuse, are also affected 11 12…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of Candida spondylodiscitis includes clinical features, laboratory results, radiological studies and microbiological tests 8. The clinical features are non-specific, and usually arise late in the course of the disease (2 to 12 months in 70% and more than 1 year in 10%) 15–17.…”

Section: Discussionmentioning

confidence: 99%

“…Involvement of the vertebral bodies can lead to vertebral compression fractures and deformity of the spine 9. The only 32% to 43% of patients presented with fever at admission and about 20% of patients complained of the neurological deficits 8. In addition, spread of infection along the anterior longitudinal ligament can lead to psoas muscle or paravertebral abscesses 9…”

Section: Discussionmentioning

confidence: 99%

“…Laboratory results frequently revealed elevated ESR and C reactive protein, whereas the white blood cell count is often normal 8. The elevation of ESR is a non-specific indicator that can be used to monitor the response to the treatment of fungal vertebral osteomyelitis 15…”

Section: Discussionmentioning

confidence: 99%

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'Fungal spondylodiscitis in a non-immunocompromised patient'

Jorge

Cardoso²,

Noronha³

et al. 2012

Case Reports

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Spondylodiscitis is an inflammatory disease, usually infectious, of one or more vertebral bodies and of corresponding intervertebral discs. The fungal aetiology is rare (less than 5% of cases), affecting mostly immunocompromised individuals. It is often a delayed diagnosis by the indolence of symptoms, presenting itself as a serious infection, which may result in important functional consequences. The authors present the case of a 75-year-old male, with constitutional complaints and intense back pain. Prior recent history of left hemicolectomy due to diverticulitis with multiple surgical complications, resulted in prolonged intensive care unit hospitalisation, and, later on, an episode of fungal endophthalmitis. The diagnosis of spondylodiscitis L5/S1 was performed by MRI. The patient underwent surgical disco-vertebral debridement and isolation of a Candida albicans was seen in the collected surgical material. No evidence of an immunossupressive status was found. Treatment was complemented with liposomal amphotericin B in the maximum recommended dose.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

'Fungal spondylodiscitis in a non-immunocompromised patient'

Jorge

Cardoso²,

Noronha³

et al. 2012

Case Reports

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Vertebral Candidiasis, the State of the Art: A Systematic Literature Review

Candura,

Perna,

Calori

et al. 2023

Acta Neurochirurgica Supplement

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Candida spondylodiscitis: a systematic review and meta-analysis of seventy two studies

Adelhoefer,

Gonzalez,

Bedi

et al. 2023

International Orthopaedics (SICOT)

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Objectives Knowledge of Candida spondylodiscitis is limited to case reports and smaller case series. Controversy remains on the most effective diagnostical and therapeutical steps once Candida is suspected. This systematic review summarized all cases of Candida spondylodiscitis reported to date concerning baseline demographics, symptoms, treatment, and prognostic factors. Methods A PRISMA-based search of PubMed, Web of Science, Embase, Scopus, and OVID Medline was performed from database inception to November 30, 2022. Reported cases of Candida spondylodiscitis were included regardless of Candida strain or spinal levels involved. Based on these criteria, 656 studies were analyzed and 72 included for analysis. Kaplan-Meier curves, Fisher’s exact, and Wilcoxon’s rank sum tests were performed. Results In total, 89 patients (67% males) treated for Candida spondylodiscitis were included. Median age was 61 years, 23% were immunocompromised, and 15% IV drug users. Median length of antifungal treatment was six months, and fluconazole (68%) most commonly used. Thirteen percent underwent debridement, 34% discectomy with and 21% without additional instrumentation. Median follow-up was 12 months. The two year survivorship free of death was 80%. The two year survivorship free of revision was 94%. Younger age (p = 0.042) and longer length of antifungal treatment (p = 0.061) were predictive of survival. Conclusion Most patients affected by Candida spondylodiscitis were males in their sixties, with one in four being immunocompromised. While one in five patients died within two years of diagnosis, younger age and prolonged antifungal treatment might play a protective role.

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Cervical Spondylodiscitis Caused by Candida Albicans in Non-Immunocompromised Patient

Cited by 16 publications

References 12 publications

'Fungal spondylodiscitis in a non-immunocompromised patient'

'Fungal spondylodiscitis in a non-immunocompromised patient'

Vertebral Candidiasis, the State of the Art: A Systematic Literature Review

Candida spondylodiscitis: a systematic review and meta-analysis of seventy two studies

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