Cervical stromal involvement can predict survival in advanced endometrial carcinoma: a review of 67 patients

Taşkın, Salih; Ortaç, Fırat; Kahraman, Korhan; Göç, Göksu; Öztuna, Derya; Güngör, Mete

doi:10.1007/s10147-011-0351-y

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…Age, histologic type, grade, depth of myometrial invasion, cervical involvement, lympho-vascular space invasion, presence or area of lymph node metastasis, the amount of the both removed and metastatic lymph nodes, presence of non-nodal extra-uterine disease and addition or type of adjuvant therapy were found to be important for survival (9,17,18,(21)(22)(23)(24)(25)(26)(27). In our study, it was found that independent prognostic factors in the patients receiving adjuvant radiotherapy were age for only recurrence and non-nodal extra-uterine disease for both recurrence and death.…”

Section: Discussionmentioning

confidence: 99%

Recurrence Pattern after Adjuvant Radiotherapy for Endometrioid Type Endometrial Cancer

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Türkmen

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et al. 2018

Gynecol Obstet Reprod Med

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Objective: To define recurrence pattern of endometrioid type endometrium cancer performed adjuvant radiotherapy.Study Design: 351 patients who underwent at least total abdominal hysterectomy with bilateral salpingo-oophorectomy and followed by adjuvant radiotherapy (vaginal brachytherapy or pelvic radiotherapy or both) for endometrioid type endometrium carcinoma were included. The patients who received systemic adjuvant treatment after surgery were excluded from the study except for 18 patients who received concomitant chemo-radiotherapy. Recurrence was categorized as pelvic recurrence included areas distal to the pelvic inlet, as abdominal recurrence included areas between pelvic inlet and diaphragm and findings such as ascites and peritonitis carcinomatosa, and the rest of recurrences including lung, cutaneous, liver parenchyma and bone as extra-abdominal recurrence.Results: The median age was 57 years (range; 29-82). 236 patients had stage I, 25 had stage II, 63 had stage III and 14 had stage IV disease (by FIGO 2009). Lymph node metastasis was determined in 21.8% of patients who underwent lymphadenectomy (n: 289). The median follow-up time was 46 months (range; 1-190). Throughout follow-up, recurrence was developed in 55 (15.7%) patients. Only pelvic recurrence was determined in 11 (3.1%) patients. There was recurrence beyond the pelvis in 44 (80%) of the recurrent patients. Thirty-five (%63.6) of recurrent patients had extra-abdominal recurrence. Twenty-three (41.8%) of recurrent patients had stage IB disease. The recurrence developed in 10% of patients with stage I&II, whereas it was occurred in 31% of patients with stage III&IV (p<0.0001).Conclusion: Radiotherapy provides local control of the disease, but recurrence is likely to be extra-pelvic and extra-abdominal in this patient group.

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Section: Discussionmentioning

confidence: 99%

Recurrence Pattern after Adjuvant Radiotherapy for Endometrioid Type Endometrial Cancer

Durmuş

Türkmen

Kılıç

et al. 2018

Gynecol Obstet Reprod Med

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“…Cervical stromal invasion is associated with increased likelihood of pelvic lymphadenopathy 40,41 and an adverse prognosis. 42,43…”

Section: Endometrial Cancermentioning

confidence: 99%

Current Strategies and Recent Advances in Gynaecological Oncology Imaging

Wong

Lai

Lee

2020

Hong Kong Journal of Radiology

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Risk factors for cervical stromal involvement in endometrioid‐type endometrial cancer

Toprak

Şahin

et al. 2021

Intl J Gynecology & Obste

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Objective The aim of this study was to identify predictors of cervical stromal involvement in women with endometrioid‐type endometrial cancer (EEC). Methods A total of 795 patients with EEC who underwent comprehensive surgical staging including pelvic and para‐aortic lymph node dissection between January 2007 and December 2018 were retrospectively analyzed. Data including age, menopausal status, serum CA‐125 levels, tumor size, lymphovascular space invasion (LVSI), depth of myometrial invasion, positive peritoneal cytology, cervical stromal involvement, histologic grade, recurrence, and follow‐up duration were recorded. Results Median follow up was 49 months. Cervical stromal invasion was found in 88 patients. Multivariate analysis revealed that presence of LVSI (hazard ratio [HR] 2, 95% confidence interval [CI] 1.02–4.25, P = 0.045), a primary tumor diameter of at least 3 cm (HR 3, 95% CI 1.31–7.25, P = 0.010), and at least 50% deep myometrial invasion (HR 2.7, 95% CI 1.37–5.41, P = 0.004) were independent risk factors for cervical stromal involvement in patients with EEC. Conclusion Our study results suggest that presence of LVSI, a primary tumor diameter of at least 3 cm, and LVSI of at least 50% seem to be independent predictors of cervical involvement in women with EEC.

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Cervical stromal involvement can predict survival in advanced endometrial carcinoma: a review of 67 patients

Abstract: Cervical stromal involvement is a poor prognostic factor in cases of advanced endometrial carcinoma. Further studies are required to describe the effect of different surgical approaches such as radical hysterectomy on survival in the presence of cervical stromal invasion.

Cited by 10 publications

References 16 publications

Recurrence Pattern after Adjuvant Radiotherapy for Endometrioid Type Endometrial Cancer

Recurrence Pattern after Adjuvant Radiotherapy for Endometrioid Type Endometrial Cancer

Current Strategies and Recent Advances in Gynaecological Oncology Imaging

Risk factors for cervical stromal involvement in endometrioid‐type endometrial cancer

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