Cetrolix Protocol versus Conventional Clomiphene Citrate Protocol in Women with Unexplained Infertility Undergoing Intrauterine Insemination: A Randomised Prospective Study

Abstract

the role of individual topics in the efficacy of IUI therapy. One of the topics was the insemination time which was done 32-36 hours after HCG injection [4]. However, it looks that among healthy women, the best time to become pregnant is if coitus occurred up to six days before ovulation [6]. Superovulation with usual doses of gonadotropins induces pregnancy in 10-15% of couples, as stated by large clinical trials [7-9]. The drawbacks of this method were an increase in the incidences of twin pregnancy (15-20%) and triplets (5-10%), thus rendering IUI as an unsafe technique in stimulated cycles [10]. It is a simple, noninvasive, and non-expensive method in assisted reproductive techniques but with a low pregnancy rate. Many studies have proved the value of gonadotropin-releasing hormone antagonist as an effective method to prevent premature luteinization. However, most of these studies failed to find a significant improvement in clinical pregnancy rates in ovarian induction IUI cycles [11-13]. Hence, the rationale intended for this randomized controlled study was to test the hypothesis that the antagonist protocol can lead