CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells

Lu, Liuyi; Pan, Ni; Huang, Zehan; Wang, Jingsong; Tang, Yong-Bo; Sun, Hong‐Shuo; Han, Hui; Yang, Haiyan; Zhu, Junzhen; Guan, Yong‐Yuan; Zhang, Bin; Li, Dong-Zhi; Wang, Guan-Lei

doi:10.1097/fjc.0000000000001257

Cited by 3 publications

(1 citation statement)

References 35 publications

(47 reference statements)

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“…Liang et al, unlike Zhao and Lu, chose the erythrocytes as the research object [9]. They found that CF patients' (whose CFTR is abnormal) erythrocytes couldn't stimulate isolated rabbit lungs to produce endogenous NO while normal erythrocytes had the opposite result.…”

Section: Hypertension and Cftr Genementioning

confidence: 99%

The bioinformatic analysis of CFTR in essential hypertension

Zhu

2024

TNS

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The CFTR gene is associated with cystic fibrosis, a genetic disease primarily affecting the respiratory and digestive systems. Essential hypertension is a common cardiovascular disorder characterized by high blood pressure. In this bioinformatic analysis, various databases and tools were used to investigate the potential mechanisms underlying this association. Gene expression data and epigenetic analyses were used to identify the biological processes between CFTR and hypertension. Additionally, genetic variants within CFTR were analysed for potential effects on hypertension susceptibility. The results of this analysis suggest that CFTR may not play a role in hypertension. Moreover, hypertension has no special epigenetic feather. Further studies are needed to confirm the mechanisms of such a phenomenon.

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Section: Hypertension and Cftr Genementioning

confidence: 99%

The bioinformatic analysis of CFTR in essential hypertension

Zhu

2024

TNS

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Angiotoxic effects of chlorinated polyfluorinated ether sulfonate, a novel perfluorooctane sulfonate substitute, in vivo and in vitro

Tan,

Lv,

et al. 2024

Journal of Hazardous Materials

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Evening Primrose Extracts Inhibit PDGF-BB-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Regulating Cell-Cycle-Related Proteins

Lee

Kim

Woo

et al. 2022

CIMB

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The proliferation and migration of vascular smooth muscle cells (VSMCs) are important factors in the occurrence of cardiovascular diseases, such as blood flow abnormalities, stroke and atherosclerosis. Evening primrose, known as Oenothera biennis, is a plant native to Korea that exerts physiological activities, such as antioxidant effects, the inhibition of lipid accumulation and the prevention of muscle atrophy. However, the function of evening primrose stem (EVP) in the regulation of VSMC proliferation and migration and the underlying mechanisms have not been identified. In this study, the effect of EVP on the platelet-derived growth factor (PDGF)-induced proliferation and migration of VSMCs was investigated. The results show that PDGF-BB-induced proliferation of VSMCs was inhibited by EVP at concentrations of 25, 50 or 100 μg/mL in a concentration-dependent manner, and a migration assay showed that EVP inhibited cell migration. Cell cycle analysis was performed to confirm the mechanism by which cell proliferation and migration was inhibited. The results indicate that proteins involved in the cell cycle, such as cyclin, CDK and phosphorylated Rb, were downregulated by EVP at concentrations of 100 μg/mL, thereby increasing the proportion of cells in the G0/G1 phase and inhibiting cell cycle progression. In the PDGF receptor (PDGFR) signaling pathway, phosphorylation of the PDGFR was inhibited by EVP at concentrations of 100 μg/mL, and PLCγ phosphorylation was also decreased. The PDGF-BB-induced effect of EVP on the proliferation of VSMCs involved the inhibition of Akt phosphorylation and the reduction in the phosphorylation of MAPK proteins such as ERK, P38 and JNK. In conclusion, the results demonstrate that EVP inhibited PDGF-BB-induced VSMC proliferation and migration by regulating cell-cycle-related proteins.

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CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 3 publications

References 35 publications

The bioinformatic analysis of CFTR in essential hypertension

The bioinformatic analysis of CFTR in essential hypertension

Angiotoxic effects of chlorinated polyfluorinated ether sulfonate, a novel perfluorooctane sulfonate substitute, in vivo and in vitro

Evening Primrose Extracts Inhibit PDGF-BB-Induced Vascular Smooth Muscle Cell Proliferation and Migration by Regulating Cell-Cycle-Related Proteins

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