Chaetochromones A – C, Three New Polyketides from Mangrove Plant Derived Endophytic Fungus <i>Phomopsis</i> sp. <scp>SCSIO</scp> 41006

Zhang, Ju; Lin, Xiuping; Li, Minke; Wang, Ying; Tian, Yongtao; Wang, Junfeng; Liu, Juan; Tu, Zhengchao; Xu, Shi‐Hai; Liu, Yonghong

doi:10.1002/cbdv.201700266

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…The 85 new chromone and its derivatives were described from 17 different genera of mangrove-associated fungi. The genus Phomopsis has again been well studied and has yielded many new chromone derivatives, including phomoxanthone F ( 146 ), 93 chaetochromones A–C ( 147–149 ), 94 phomochromenones A–C ( 150–152 ), 95 phomopsichins A–D ( 153–156 ), 96 phomopsol B ( 157 ), 97 and the dimer phomopsis-H76 A ( 158 ), 98 which accelerated the growth of subintestinal vessel plexus (SIV) branch markedly. The strains of Aspergillus yielded two new chromones, aspergone ( 159 ) 99 and the antifungal ( S )-5-hydroxy-2,6-dimethyl-4 H -furo[3,4- g ]benzopyran-4,8(6 H )-dione ( 160 ).…”

Section: Secondary Metabolites From Mangrove Fungimentioning

confidence: 99%

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

et al. 2022

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Section: Secondary Metabolites From Mangrove Fungimentioning

confidence: 99%

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

et al. 2022

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“…Microorganisms, especially endophytic fungi that reside in the tissue of living mangrove plants, seem to play a major role in meeting the general demand for new biologically active substances . We recently reported a range of new bioactive secondary metabolites from endophytic fungi of mangrove plants, including guignardins A–F, pestalamine A, pestalols A–E, cladosporone A, new phenyl derivatives, chaetochromones A–C, and four new meroterpenoids, some of them exerted various bioactivities including cytotoxicity, anti‐PTP1B, anti‐SIRT1, antivirus, antituberculosis, anti‐inflammatory, and antibacterial. As a continued research for discovering structurally novel and biologically active natural products from mangrove plant endophytic fungi, the fungal strain C. tropicale SCSIO 41022 was derived from leaves of the mangrove plant K. candel growing in Daya Bay, South China Sea.…”

Section: Introductionmentioning

confidence: 99%

Colletoindole A from the Mangrove Plant Endophytic Fungus Colletotrichum tropicale SCSIO 41022

Lin

et al. 2020

Chemistry & Biodiversity

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A new indole derivative colletoindole A (1), along with two new indole derivatives (2 and 3) and one known compound acropyrone (4) were isolated from cultures of Colletotrichum tropicale SCSIO 41022 derived from a mangrove plant Kandelia candel. The structures of 1–4 were determined by analysis of NMR and MS data. The cytotoxicity of 1, 2 and 4, and the COX‐2 inhibitory activity of 1 and 2 were evaluated.

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“…sh917 and the mangrove-derived fungus Phomopsis sp. SCSIO 41 006 [13,14]. In our ongoing search for bioactive compounds from endophytic fungi, a solid-state fermentation of Phomopsis sp.…”

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Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp. CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways

et al. 2020

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Three previously undescribed natural products, phomopsinin A – C (1 – 3), together with three known compounds, namely, cis-hydroxymellein (4), phomoxanthone A (5) and cytochalasin L-696,474 (6), were isolated from the solid culture of Phomopsis sp. CAM212, an endophytic fungus obtained from Garcinia xanthochymus. Their structures were determined on the basis of spectroscopic data, including IR, NMR, and MS. The absolute configurations of 1 and 2 were assigned by comparing their experimental and calculated ECD spectra. Acetylation of compound 1 yielded 1a, a new natural product derivative that was tested together with other isolated compounds on lipopolysaccharide-stimulated RAW 264.7 cells. Cytochalasin L-696,474 (6) was found to significantly inhibit nitric oxide production, but was highly cytotoxic to the treated cells, whereas compound 1 slightly inhibited nitric oxide production, which was not significantly different compared to lipopolysaccharide-treated cells. Remarkably, the acetylated derivative of 1, compound 1a, significantly inhibited nitric oxide production with an IC50 value of 14.8 µM and no cytotoxic effect on treated cells, thereby showing the importance of the acetyl group in the anti-inflammatory activity of 1a. The study of the mechanism of action revealed that 1a decreases the expression of inducible nitric oxide synthase, cyclooxygenase 2, and proinflammatory cytokine IL-6 without an effect on IL-1β expression. Moreover, it was found that 1a exerts its anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 macrophage cells by downregulating the activation of ERK1/2 and by preventing the translocation of nuclear factor κB. Thus, derivatives of phomopsinin A (1), such as compound 1a, could provide new anti-inflammatory leads.

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Chaetochromones A – C, Three New Polyketides from Mangrove Plant Derived Endophytic Fungus Phomopsis sp. SCSIO 41006

Cited by 6 publications

References 14 publications

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

Colletoindole A from the Mangrove Plant Endophytic Fungus Colletotrichum tropicale SCSIO 41022

Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp. CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways

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