2022
DOI: 10.3390/ph15101250
|View full text |Cite
|
Sign up to set email alerts
|

Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry

Abstract: Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an α,β-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior. The present review aims to summarize the structures from natural sources, synthesis methods, biological characteristics against infectious and non-infectious diseases, and uses of chalcones over the past decade, and their structure–activity relationship studies … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
21
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 59 publications
(24 citation statements)
references
References 262 publications
0
21
0
Order By: Relevance
“…Molecular docking is an important computational method of finding new drug candidates by analyzing their binding affinity toward particular receptors. , The crystal structures of selected target proteins were collected from the Protein Databank (PDB ID: 4KZN for VEGF, 7NH5 for Akt, 5W9C for ER, 3QYC for HER-2, and 5GPG for mTOR). The active sites or binding pockets of the targets were identified through a cocrystallized ligand for the corresponding protein or via literature review.…”
Section: Resultsmentioning
confidence: 99%
“…Molecular docking is an important computational method of finding new drug candidates by analyzing their binding affinity toward particular receptors. , The crystal structures of selected target proteins were collected from the Protein Databank (PDB ID: 4KZN for VEGF, 7NH5 for Akt, 5W9C for ER, 3QYC for HER-2, and 5GPG for mTOR). The active sites or binding pockets of the targets were identified through a cocrystallized ligand for the corresponding protein or via literature review.…”
Section: Resultsmentioning
confidence: 99%
“…2). 20 Several hydroxy chalcones have medical and pharmaceutical uses based on anti-cancer, 21,22 antioxidant, 19 antiinflammatory, 23,24 antidiabetic, 25 anti-microbial, and neuroprotective properties. [26][27][28] Particularly, the outcomes of clinical trials for the treatment of trunk or branch varicosity and chronic venous lymphatic insufficiency with hesperidin methylchalcone and hesperidin trimethylchalcone (displayed in Fig.…”
Section: Introductionmentioning
confidence: 99%
“…This scaffold can exist either as Z (cis) or E (trans) isomers in which the latter is thermodynamically more stable than the former [26] . Over the years, chalcone scaffolds have exhibited impressive varied pharmacological activities including anti‐inflammatory, anti‐fungal, anti‐bacterial, antioxidant, anti‐viral, and anti‐cancer [27] …”
Section: Introductionmentioning
confidence: 99%
“…[26] Over the years, chalcone scaffolds have exhibited impressive varied pharmacological activities including anti-inflammatory, anti-fungal, anti-bacterial, antioxidant, anti-viral, and anti-cancer. [27] Mainly, chalcone derivatives could be synthesized through a Claisen-Schmidt reaction (Figure 2A) in an acidic or basic medium. Another synthetic route is Friedel-Craft's acylation, (Figure 2B) which includes strong Lewis acid (aluminium trichloride AlCl 3 ) as a catalyst that activates the electrophile (acyl chloride or acid anhydride) yielding an acylium ion.…”
Section: Introductionmentioning
confidence: 99%