2021
DOI: 10.7324/japs.2021.11s101
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Chalcones: A review on synthesis and pharmacological activities

Abstract: Chalcone is a privileged species with medicinal significance as it consists of reactive ketoethylenic moiety-CO-CH=CH-belonging to flavonoids. The presence of a reactive α, β-unsaturated carbonyl function in chalcone and its derivatives is the reason for its pharmacological activities. Chalcones exhibit a wide spectrum of pharmacological effects such as antioxidant, antibacterial, anthelmintic, antiulcer, antiviral, insecticidal, antiprotozoal, anticancer, anti-Suzuki's reaction, etc. The purpose of this revie… Show more

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Cited by 18 publications
(13 citation statements)
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“…Moreover, bis-chalcones 2 have been derived from acetone, bis-chalcones 4 from cyclic ketones, and bis-chalcones 5 from tetrahydrohexa heterocyclic ketones. Other chalcones (6,7) are analogs of cinnamaldehyde and aza/thioketones (Figure 3A). [17,20,[22][23][24] Some synthetic chalcones have been approved as drugs for various treatments, including metochalcone (a choleretic), hesperidin methyl chalcone (a vascular protector), and sofalcone (an antiulcer and mucoprotective agent) (Figure 3B).…”
Section: Chemical Synthesis Of Chalconesmentioning
confidence: 99%
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“…Moreover, bis-chalcones 2 have been derived from acetone, bis-chalcones 4 from cyclic ketones, and bis-chalcones 5 from tetrahydrohexa heterocyclic ketones. Other chalcones (6,7) are analogs of cinnamaldehyde and aza/thioketones (Figure 3A). [17,20,[22][23][24] Some synthetic chalcones have been approved as drugs for various treatments, including metochalcone (a choleretic), hesperidin methyl chalcone (a vascular protector), and sofalcone (an antiulcer and mucoprotective agent) (Figure 3B).…”
Section: Chemical Synthesis Of Chalconesmentioning
confidence: 99%
“…Accordingly, the alcohol was oxidized to the corresponding aldehyde, which underwent condensation with the arylketone (Scheme 4). [1,[5][6][7]…”
Section: Additional Strategiesmentioning
confidence: 99%
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