Chalkley Microvessel but not Lymphatic Vessel Density Correlates with Axillary Lymph Node Metastasis in Primary Breast Cancers

Kanngurn, Samornmas; Thongsuksai, Paramee; Chewatanakornkul, Siripong

doi:10.7314/apjcp.2013.14.1.583

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…Therefore, we investigated the influence of angiogenesis on the prognosis. MVD, as an indicator of neovascularization, has been reported to be associated with invasiveness and a high grade of malignancy in many types of cancer such as breast cancer, prostatic cancer and laryngeal cancer [23][24][25]. In the case of LMS, the relationship between MVD and outcome has been controversial, and previous studies have mostly involved LMS arising from the uterus [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma

Zhuang

Zhu

et al. 2015

Future Oncol.

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The median PFS in the 22 patients was 9 months. Microvessel density in tumor tissues, which was evaluated via CD34 expression in 16 cases, and the presence of metastasis on admission were both found to be correlated with PFS in a Kaplan-Meier analysis, but not in a multivariate analysis. The multivariate analysis did, however, show that complete resection of tumors and the FNCLCC (Fédération Nationale des Centres de Lutte Contre Le Cancer) disease grade were independent factors predicting PFS.

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Section: Discussionmentioning

confidence: 99%

Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma

Zhuang

Zhu

et al. 2015

Future Oncol.

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“…Among the included 13 studies, which provided sufficient data to evaluate the relationship between LVI and LNM, eleven of them [13, 14, 21, 23–26, 31–33, 36] described the detailed number of LVI occurrence within LNM negative group and LNM positive group. In LNM negative group ( n = 784), 187 (23.85%) patients presented with LVI; while in LNM positive group ( n = 602), 276 (45.85%) patients presented with LVI.…”

Section: Resultsmentioning

confidence: 99%

The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis

Zhang

et al. 2016

Oncotarget

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Lymph node status is one of the key parameters used for determining the stage of breast cancer progression. The relationship of lymphatic vessel density (LVD), lymphovascular invasion (LVI), and lymph node metastasis (LNM) has not been clearly demonstrated yet. Databases of PubMed, Embase, and Web of Science were searched from inception up to 25 May 2016. Spearman correlation coefficient (r) and 95% confidence interval (CI) were used to determine the relationship within each group. Based on pre-established inclusion criteria, 28 studies involving 2920 breast cancer patients were included in this study. The r values of LVD-LVI, LVD-LNM, and LVI-LNM were 0.45 (95% CI: 0.31 to 0.57), 0.32 (95% CI: 0.23 to 0.40), and 0.24 (95% CI: 0.19 to 0.28), respectively. Compared with intratumoral LVD, peritumoral LVD showed more robust correlation with LVI (r = 0.53, 95% CI: 0.27 to 0.72) and LNM (r = 0.33, 95% CI: 0.18 to 0.46). The patients in LNM positive group presented with higher LVI detection rate of 45.85%, while in LNM negative group with detection rate of 23.85%. The results describe a triangle relationship between LVD, LVI, and LNM in breast cancer. Both LVD and LVI are indicated to be valuable predictors of LNM occurrence. Compared with intratumoral lymphatic vessels, peritumoral lymphatics might be the main disseminate route for breast tumor cells.

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“…Lymphangiogenesis has shown different properties and significance when compared with angiogenesis in primary epithelial malignancies, as well as in the related lymph node metastases 13, 14. However, the theme of our paper is the nature of lymphangiogenesis in the malignant tumor, cHL, which develops primarily in lymph nodes.…”

Section: Discussionmentioning

confidence: 95%

Lymphangiogenesis in Classical Hodgkin Lymphoma - Preliminary Study with Clinicopathological Correlations

Benharroch¹,

Prinsloo²,

Gopas³

et al. 2016

J. Cancer

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A role for lymphangiogenesis in metastatic breast and prostate cancers has been suggested recently. The relevance of lymphangiogenesis in cancer as a rule, and more specifically in classical Hodgkin lymphoma, is poorly understood in comparison with that of angiogenesis. In a preliminary (pilot) study we have investigated the role of lymphatic vessels growth in 19 cases of classical Hodgkin lymphoma stained with the D2-40 (podoplanin) antibody. In each case, three lymphatic vessels hot spots were scrutinized twice. Of the 57 hot spots thus identified, we chose 15 at random for photography, microvessel counting and image analysis. We determined the mean perimeter, surface area, major axis length and complexity factor for each hot spot and correlated them with clinical and biological features of classical Hodgkin lymphoma. No correlations were found with clinical features. No associations were noted with the standard immuno-markers of classical Hodgkin lymphoma. However, significant inverse correlations were shown with pRb, BAX and IκB-α expression. The mean lymphatic major axis length was inversely correlated with the complexity factor. Last, we carried out an additional clinicopathological correlation of the expression of pRb, BAX and IκB-α in a cohort of classical Hodgkin lymphoma patients previously published.

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Chalkley Microvessel but not Lymphatic Vessel Density Correlates with Axillary Lymph Node Metastasis in Primary Breast Cancers

Cited by 6 publications

References 26 publications

Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma

Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma

The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis

Lymphangiogenesis in Classical Hodgkin Lymphoma - Preliminary Study with Clinicopathological Correlations

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