The first case of the COVID-19 pandemic in Indonesia was discovered on March 2, 2020. The COVID-19 pandemic is a multidimensional crisis that has had a negative impact on various fields, including the journalism sector, especially press freedom, press democracy, and the press as a pillar of the Fourth Estate. The aim of this research is to analyse the impact of interest manipulation on the independence of television journalists in reporting about the COVID-19 vaccine. This research uses a case study that examines the editorial background in reporting on the COVID-19 vaccine. This research aims to reveal the manipulation of interests behind news about the COVID-19 vaccine. The research object consists of four private television stations selected based on a purposive sample, namely iNews TV, Metro TV, TV One, and Trans 7. The government guarantees that it will not hinder the critical power of journalists, so that media independence remains a priority. However, journalists must pay attention to the impact of the news and the needs of society. The results of the research show that there are irregularities in the newsroom regarding the government\'s involvement in regulation. The government, through the National Board for Disaster Management (BNPB), is trying to intervene in journalistic work so that reporting is in line with the wishes of the government as the main policymaker. In addition, researchers found that there was intervention from internal and external companies that attempted to influence the content and direction of editorial reporting policies regarding the COVID-19 vaccine.