Challenges and strategies for the delivery of biologics to the cornea

Wels, Mike; Roels, Dimitri; Raemdonck, Koen; Smedt, Stefaan C. De; Sauvage, Félix

doi:10.1016/j.jconrel.2021.04.008

Cited by 23 publications

(41 citation statements)

References 137 publications

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“…In developing artificial cornea materials, we are concerned with function and biocompatibility [ 17 ]. In order to improve the function, the implant must possess appropriate properties, such as mechanical strength, stability of shape, moisturizing ability, and light transmittance, just to name a few [ 20 , 21 , 28 , 30 ]. As we know, each part of the corneal tissue has a unique, subtle, layered structure.…”

Section: Discussionmentioning

confidence: 99%

Collagen Film with Bionic Layered Structure and High Light Transmittance for Personalized Corneal Repair Fabricated by Controlled Solvent Evaporation Technique

Zhang

Kong

et al. 2022

JFB

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Corneal blindness is a common phenomenon, and corneal transplantation is an effective treatment for corneal defects. However, there is usually a mismatch between the corneal repair material and the degree of the patient’s corneal defect. Therefore, patients with different corneal defects need suitable corneal repair materials with a specific microstructure for personalized treatment. In this research, collagen films with bionic structures were fabricated through ethanol evaporation technique by regulating the volume ratios of collagen solution: ethanol = 10:0(Col)/9:1(CC91)/8:2(CC82)/CC73(CC73). Under various preparation conditions, the obtained collagen films contain layered structures of different density. SEM photos show that the CC73 film with a dense layer arrangement has a microstructure similar to that of the corneal epithelial layer, whereas the Col film has a loose layered structure similar to that of the corneal stroma layer. Four kinds of collagen films showed different optical properties and water absorption ability. A more ordered arrangement of internal layer structure leads to better mechanical properties of the collagen film. In view of this, we think that these collagen films with different microstructures and different interlayer spacing may have huge potential applications for personalized corneal repair.

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Section: Discussionmentioning

confidence: 99%

Collagen Film with Bionic Layered Structure and High Light Transmittance for Personalized Corneal Repair Fabricated by Controlled Solvent Evaporation Technique

Zhang

Kong

et al. 2022

JFB

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show abstract

“…Many ophthalmic diseases, such as trauma and dry eyes, are due to malfunctions at the level of the cornea, leading to severe visual impairment. Often, corneal transplantation is the only therapeutic option for these patient to improve quality of life [ 65 ]. Nucleic acid therapeutics could offer new therapeutic opportunities for corneal repair, albeit that their functional delivery to the corneal epithelium remains challenging.…”

Section: Resultsmentioning

confidence: 99%

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Bogaert

Sauvage

Guagliardo

et al. 2022

Journal of Controlled Release

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“…The cornea is located at the anterior side of the eye and its main role is to protect the eye from foreign substances. Besides the protective function, the cornea also focuses incoming light toward the lens and the retina, 1 explaining why diseases affecting the cornea strongly impact vision. Corneal blindness is indeed the fourth leading cause of blindness worldwide after cataract, glaucoma, and retinal diseases like age-related macular degeneration (AMD).…”

Section: Introductionmentioning

confidence: 99%

Influence of the Size and Charge of Carbon Quantum Dots on Their Corneal Penetration and Permeation Enhancing Properties

Hoon

Barras

Swebocki

et al. 2023

ACS Appl. Mater. Interfaces

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Reaching the corneal endothelium through the topical administration of therapeutic drugs remains a challenge in ophthalmology. Besides, endothelial cells are not able to regenerate, and diseases at this site can lead to corneal blindness. Targeting the corneal endothelium implies efficient penetration through the three corneal layers, which still remains difficult for small molecules. Carbon quantum dots (CQDs) have demonstrated great potential for ocular nanomedicine. This study focuses on the corneal penetration abilities of differently charged CQDs and their use as permeation enhancers for drugs. Excised whole bovine eyes were used as an ex vivo model to investigate corneal penetration of CQDs derived from glucosamine using β-alanine, ethylenediamine, or spermidine as a passivation agent. It was found that negatively charged CQDs have limited corneal penetration ability, while positively charged CQDs derived from glucosamine hydrochloride and spermidine (CQD-S) penetrate the entire corneal epithelium all the way down to the endothelium. CQD-S were shown to enhance the penetration of FITC-dextran 150 kDa, suggesting that they could be used as efficient penetration enhancers for therapeutic delivery to the corneal endothelium.

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Challenges and strategies for the delivery of biologics to the cornea

Cited by 23 publications

References 137 publications

Collagen Film with Bionic Layered Structure and High Light Transmittance for Personalized Corneal Repair Fabricated by Controlled Solvent Evaporation Technique

Collagen Film with Bionic Layered Structure and High Light Transmittance for Personalized Corneal Repair Fabricated by Controlled Solvent Evaporation Technique

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Influence of the Size and Charge of Carbon Quantum Dots on Their Corneal Penetration and Permeation Enhancing Properties

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