Challenges in differential diagnosis between primary and secondary forms of hyperparathyroidism

Mokrysheva, Natalia; Георгиевна, Мокрышева Наталья; Eremkina, Anna; Константиновна, Еремкина Анна; Mirnaya, Svetlana; Сергеевна, Мирная Светлана; Ковалева, Е. В.; Владимировна, Ковалева Елена

doi:10.14341/omet2017348-53

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…Гіперпаратиреоз (ГПТ) -ендокринне захворювання, що характеризується надмірним синтезом і секрецією паратиреоїдного гормона (ПТГ) внаслідок патологічної трансформації в одній або декількох прищитоподібних залозах (ПЩЗ) [1,2]. Первинний гіперпаратиреоз (пГПТ) передбачає поєднання підвищеного рівня ПТГ і кальцію крові (Са) у результаті первинної патології ПЩЗ [3,4].…”

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Diagnosis and treatment of primary hyperparathyroidism (20 years of own experience and literature review)

Karachentsev

Sazonov

Khaziev

et al. 2022

Mìžnarodnij endokrinologìčnij žurnal

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Background. Currently, primary hyperparathyroidism (pHPT) is the third most common endocrine disease after thyroid gland pathology and diabetes mellitus. Untimely diagnosis leads to a severe course of the disease with the development of disabling deformations — osteoporotic fractures, recurrent stone formation in the urinary tract, gastrointestinal bleeding, etc., as well as to an increased risk of premature death. The purpose of the study is to assess the dynamics of detection of thyroid disease (thyroid) for the period 2000–2019. Materials and methods. Since 2000, based on the surgical department of the clinic of the State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine”, 205 surgeries have been carried out for pHPT (in 188 women and 17 men: 91.7 and 8.3 %). Results. Since 2008, there has been a steady increase in the number of cases. The incidence of pHPT in women increases with age and becomes significantly higher at the age of 50–69 years. At the same time, the gap between women and men is widening, the reason for which needs to be studied. The proportional ratio of the number of patients with asymptomatic and clinically pronounced course persists for 20 years and is approximately 2 : 1. In countries where blood calcium screening has been introduced, the proportion of asymptomatic forms reaches 80 %. The obtained data confirm the fact of untimely diagnosis of pHPT in Ukraine, which requires the introduction of large-scale population screening in the form of a questionnaire survey and study of serum calcium. Conclusions. A positive contribution to the timely detection of pHPT can be made by activating the work of postgraduate (continuous) education institutions in this direction, primarily the departments of endocrinology based on endocrinological clinics with surgical departments.

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Diagnosis and treatment of primary hyperparathyroidism (20 years of own experience and literature review)

Karachentsev

Sazonov

Khaziev

et al. 2022

Mìžnarodnij endokrinologìčnij žurnal

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Hyperparathyroidism and Vitamin D: Relationship Difficulties

Суплотова

Судницына

et al. 2022

Osteopor Bone Dis

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Hyperparathyroidism is a clinical and laboratory syndrome characterized by hyperproduction of parathyroid hormone (PTH) by cells of the parathyroid glands (PTG) and is subdivided, depending on the cause of its occurrence, into primary (PHPT), secondary (SHPT) and tertiary hyperparathyroidism (THPT). To date, only a few scientific papers have been published on the features of the relationship between vitamin D and various forms of hyperparathyroidism, there may be several reasons for this. First, this is due to the fact that the true prevalence of vitamin D deficiency in hyperparathyroidism is unknown. Secondly, difficulties in the differential diagnosis of hyperparathyroidism sometimes entail not always justified surgical intervention with the potential development of complications, which, of course, is a rather narrow area of interest, both in endocrinology in particular and in medicine in general. Thirdly, the asymptomatic, often hidden, latent nature of the variety of multiple organ clinical manifestations of hyperparathyroidism, in combination with low levels of 25(OH)D, as the disease progresses, can lead to a significant decrease in the quality and life expectancy of patients. The combination of these arguments prompted us to summarize all the data available to date on the complexity of the relationship between vitamin D and various forms of hyperparathyroidism.

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The short test with active metabolites of vitamin D in differential diagnosis between primary normocalcemic and secondary hyperparathyroidism for inpatient treatment

Karaseva,

Eremkina,

Elfimova

et al. 2022

Profil. med.

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Challenges in differential diagnosis between primary and secondary forms of hyperparathyroidism

Cited by 6 publications

References 17 publications

Diagnosis and treatment of primary hyperparathyroidism (20 years of own experience and literature review)

Diagnosis and treatment of primary hyperparathyroidism (20 years of own experience and literature review)

Hyperparathyroidism and Vitamin D: Relationship Difficulties

The short test with active metabolites of vitamin D in differential diagnosis between primary normocalcemic and secondary hyperparathyroidism for inpatient treatment

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