Challenges in Predicting the Change in the Cumulative Exposure of New Tobacco and Related Products Based on Emissions and Toxicity Dose–Response Data

Abstract

Many novel tobacco products have been developed in recent years. Although many may emit lower levels of several toxicants, their risk in the long term remains unclear. We previously published a method for the exposure assessment of mixtures that can be used to compare the changes in cumulative exposure to carcinogens among tobacco products. While further developing this method by including more carcinogens or to explore its application to non-cancer endpoints, we encountered a lack of data that are required for better-substantiated conclusions regarding differences in exposure between products. In this special communication, we argue the case for more data on adverse health effects, as well as more data on the composition of the emissions from tobacco products. Such information can be used to identify significant changes in relevance to health using the cumulative exposure method with different products and to substantiate regulatory decisions.

The Product Science of Electrically Heated Tobacco Products: An Updated Narrative Review of the Scientific Literature

“…Separate authors have, however, concluded that the available datasets in relation to HTPs remain limited and conclusions relating to HTPs should be taken with caution [55]. It is apparent that further research is warranted, and additional epidemiological studies into the long-term effects of HTP use may help to determine the absolute cancer risk associated with HTP use [56].…”

“…With respect to toxicological risk assessments, the available evidence indicates that HTP use may be associated with reduced cancer- and non-cancer-related risk when compared to cigarette smoking [ 52 - 54 ]. Separate authors have, however, concluded that the available datasets in relation to HTPs remain limited and conclusions relating to HTPs should be taken with caution [ 55 ]. It is apparent that further research is warranted, and additional epidemiological studies into the long-term effects of HTP use may help to determine the absolute cancer risk associated with HTP use [ 56 ].…”

Rauchen – Wissenswertes über Tabak und alternative Produkte

“…Dies beinhaltet auch die Untersuchung der (neuen) Aromastoffe in den Einwegtabaksticks sowie deren Wechselwirkungen mit den bekannten Tabakinhaltsstoffen nach Erhitzung auf bis zu 350 °C. Möglicherweise entstehen auch völlig neue chemische Verbindungen [26].…”