Challenges in Prediction and Diagnosis of Alcohol Withdrawal Syndrome and Wernicke Encephalopathy

Sechi, Gian Pietro; Sechi, Maria Margherita

doi:10.1001/jamainternmed.2020.3558

Cited by 1 publication

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, the diagnosis of WE, and thiamine treatment should mandatorily be made within the first two weeks after the onset of initial symptoms/signs indicative of possible TD, during the time frame so-called “stage of reversible biochemical lesions”, when high-doses parenteral thiamine can completely reverse brain damage. Whereas, after about two weeks, irreversible structural brain lesions in specific diencephalic and brainstem areas usually occur, with consequent lack of therapeutic efficacy of thiamine replacement [ 24 , 25 , 66 ].…”

Section: Thiaminementioning

confidence: 99%

Thiamine as a Possible Neuroprotective Strategy in Neonatal Hypoxic-Ischemic Encephalopathy

et al. 2021

Self Cite

View full text Add to dashboard Cite

On the basis that similar biochemical and histological sequences of events occur in the brain during thiamine deficiency and hypoxia/ischemia related brain damage, we have planned this review to discuss the possible therapeutic role of thiamine and its derivatives in the management of neonatal hypoxic-ischemic encephalopathy (HIE). Among the many benefits, thiamine per se as antioxidant, given intravenously (IV) at high doses, defined as dosage greater than 100 mg IV daily, should counteract the damaging effects of reactive oxygen and nitrogen species in the brain, including the reaction of peroxynitrite with the tyrosine residues of the major enzymes involved in intracellular glucose metabolism, which plays a key pathophysiological role in HIE in neonates. Accordingly, it is conceivable that, in neonatal HIE, the blockade of intracellular progressive oxidative stress and the rescue of mitochondrial function mediated by thiamine and its derivatives can lead to a definite neuroprotective effect. Because therapeutic hypothermia and thiamine may both act on the latent period of HIE damage, a synergistic effect of these therapeutic strategies is likely. Thiamine treatment may be especially important in mild HIE and in areas of the world where there is limited access to expensive hypothermia equipment.

show abstract

Section: Thiaminementioning

confidence: 99%

Thiamine as a Possible Neuroprotective Strategy in Neonatal Hypoxic-Ischemic Encephalopathy

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Challenges in Prediction and Diagnosis of Alcohol Withdrawal Syndrome and Wernicke Encephalopathy

Abstract: Conflict of Interest Disclosures: None reported.1. Brothers TD, Bach P. Challenges in prediction, diagnosis, and treatment of alcohol withdrawal in medically ill hospitalized patients: a teachable moment.

Cited by 1 publication

References 8 publications

Thiamine as a Possible Neuroprotective Strategy in Neonatal Hypoxic-Ischemic Encephalopathy

Thiamine as a Possible Neuroprotective Strategy in Neonatal Hypoxic-Ischemic Encephalopathy

Contact Info

Product

Resources

About