Challenges in Therapeutically Targeting the RNA‐Recognition Motif
Stefan Schmeing,
Peter 't Hart
Abstract:The RNA recognition motif (RRM) is the most common RNA binding domain found in the human proteome. RRM domains provide RNA‐binding proteins with sequence specific RNA recognition allowing them to participate in RNA‐centric processes such as mRNA maturation, translation initiation, splicing, and RNA degradation. They are drivers of various diseases through overexpression or mutation, making them attractive therapeutic targets and addressing these proteins through their RRM domains with chemical compounds is gai… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.