Challenging neurovascular coupling through complex and variable duration cognitive paradigms: A subcomponent analysis

Intharakham, Kannakorn; Surti, Farhaana B.S.; Beishon, Lucy; Panerai, Ronney B.; Robinson, Thompson

doi:10.1016/j.medengphy.2022.103921

Cited by 2 publications

(4 citation statements)

References 70 publications

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“…70 –72 Therefore, dCA capacity might be reduced by the temporal effect of metabolic demand with a short duration of stimulation. Furthermore, a high velocity subcomponent due to critical closing pressure (V CrCP ) (possibly representing metabolic activation) 54,73 response was seen in the shortest (05 s) duration paradigm in our previous study, 22 concomitantly with the lowest ARI estimates for these tasks. These findings suggest thought processes with a short duration during the stream of consciousness might be impacting the results.…”

Section: Discussionmentioning

confidence: 61%

“…A detailed description of methods have been reported previously. 22 The protocol consisted of two visits, using the same protocol, to allow assessment of reproducibility. The average time interval between visits 1 and 2 was approximately six months (170-232 days).…”

Section: Subjects and Measurementsmentioning

confidence: 99%

“…More detailed information of this aspect of the protocol, including a schematic representation of the timecourse of task presentation, can be found in. 22…”

Section: Subjects and Measurementsmentioning

confidence: 99%

“…This is an evolving challenge that still needs much more research and future studies. Thirdly, we have used only NW and SS tasks, 22,25 corresponding to fluency and attention cognitive domains, to study the interaction between dCA response during neuroactivation with tasks of variable complexity and duration. These tasks have been used in several previous studies 26,27 and the fact they are part of a widely used clinical tool 30 support their choice to further standardise NVC methods across studies and research centres.…”

Section: Limitationsmentioning

confidence: 99%

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Depression of dynamic cerebral autoregulation during neural activation: The role of responders and non-responders

Ladthavorlaphatt,

Surti,

Beishon

et al. 2024

J Cereb Blood Flow Metab

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Neurovascular coupling (NVC) interaction with dynamic cerebral autoregulation (dCA) remains unclear. We investigated the effect of task complexity and duration on the interaction with dCA. Sixteen healthy participants (31.6 ± 11.6 years) performed verbal fluency (naming-words (NW)) and serial subtraction (SS) paradigms, of varying complexity, at durations of 05, 30 and 60 s. The autoregulation index (ARI), was estimated from the bilateral middle cerebral artery blood velocity (MCAv) step response, calculated by transfer function analysis (TFA), for each paradigm during unstimulated (2 min) and neuroactivated (1 min) segments. Intraclass correlation (ICC) and coefficient of variation (CV) determined reproducibility for two visits and objective criteria were applied to classify responders (R) and non-responders (NoR) to task-induced MCAv increase. ICC values demonstrated fair reproducibility in all tasks. ARI decreased in right (RH) and left (LH) hemispheres, irrespective of paradigm complexity and duration (p < 0.0001). Bilateral ARI estimates were significantly decreased during NW for the R group only (p < 0.0001) but were reduced in both R (p < 0.0001) and NoR (p = 0.03) groups for SS tasks compared with baseline. The reproducible attenuation of dCA efficiency due to paradigm-induced NVC response, its interaction, and different behaviour in R and NoR, warrant further research in different physiological and clinical conditions.

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Section: Discussionmentioning

confidence: 61%

Section: Subjects and Measurementsmentioning

confidence: 99%

“…More detailed information of this aspect of the protocol, including a schematic representation of the timecourse of task presentation, can be found in. 22…”

Section: Subjects and Measurementsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

See 2 more Smart Citations

Depression of dynamic cerebral autoregulation during neural activation: The role of responders and non-responders

Ladthavorlaphatt,

Surti,

Beishon

et al. 2024

J Cereb Blood Flow Metab

Self Cite

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Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement

Ball,

Hills,

Altaf

et al. 2024

J Cereb Blood Flow Metab

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Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task activation protocols, but with significant methodological heterogeneity between studies, hindering cross-study comparisons. Therefore, this review aimed to summarise and compare available methods for TCD-based healthy NVC assessments. Medline (Ovid), Scopus, Web of Science, EMBASE (Ovid) and CINAHL were searched using a predefined search strategy (PROSPERO: CRD42019153228), generating 6006 articles. Included studies contained TCD-based assessments of NVC in healthy adults. Study quality was assessed using a checklist, and findings were synthesised narratively. 76 studies (2697 participants) met the review criteria. There was significant heterogeneity in the participant position used (e.g., seated vs supine), in TCD equipment, and vessel insonated (e.g. middle, posterior, and anterior cerebral arteries). Larger, more significant, TCD-based NVC responses typically included a seated position, baseline durations >one-minute, extraneous light control, and implementation of previously validated protocols. In addition, complementary, combined position, vessel insonated and stimulation type protocols were associated with more significant NVC results. Recommendations are detailed here, but further investigation is required in patient populations, for further optimisation of TCD-based NVC assessments.

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Challenging neurovascular coupling through complex and variable duration cognitive paradigms: A subcomponent analysis

Cited by 2 publications

References 70 publications

Depression of dynamic cerebral autoregulation during neural activation: The role of responders and non-responders

Depression of dynamic cerebral autoregulation during neural activation: The role of responders and non-responders

Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement

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