Change in Optic Disk Topography After Trabeculectomy

Irak, Inci; Zangwill, Linda M.; Garden, Valerie; Shakiba, Sima; Weinreb, Robert N.

doi:10.1016/s0002-9394(14)70488-x

Cited by 93 publications

(74 citation statements)

References 11 publications

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“…Although smaller fields may enable the detection of subtle changes, it should be noted that other authors were able to detect statistically significant changes with 151-field images. 6 Our results confirm a previous finding by our group, which on different settings showed no significant changes in short-term perimetric variability after trabeculectomy. 22 Still, the use of a small number of VF tests per patient may limit our results, as larger series of tests are usually necessary to discriminate true change from fluctuation.…”

Section: Short-term Changes After Trabeculectomy M Figus Et Alsupporting

confidence: 92%

“…These findings are comparable with other studies in which the changes in RNFL height were shown by linear regression model to be pressure dependent. 6,10 In particular, segmental analysis showed a significant change in rim volume in the nasal, inferonasal, superonasal, and superotemporal sectors. 7 These authors have suggested that the improvement is limited to the nasal hemidisc and the adjacent RNFL because this area tends to be least affected by the disease, so nerve fiber bundle compression is not as long-standing as that within the temporal hemidisc.…”

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 95%

“…4,5 Reports about the ONH have demonstrated a significant change of some parameters and reversal of cupping. [6][7][8] Structure and function relationship after trabeculectomy have just been previously studied. Some reports have suggested that improvement in disk appearance would correspond to improvement of visual function, 9,10 other authors have not shown any significant change of visual field after trabeculectomy.…”

Section: Introductionmentioning

confidence: 99%

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Short-term changes in the optic nerve head and visual field after trabeculectomy

Figus

Lazzeri

Nardi

et al. 2011

Eye

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Aims or Purpose To evaluate short-term changes in optic nerve head topography and visual field induced by surgical reduction of intraocular pressure. Methods A prospective study was performed on 56 eyes of 56 patients with uncontrolled primary open-angle glaucoma despite maximum medical therapy, which underwent trabeculectomy. Optic nerve head evaluations by means of Heidelberg Retina Tomograph, and visual field tests were performed pre-operatively, and at 3 and 6 months after surgery. Differences in intraocular pressure, visual field indices, and Heidelberg Retina Tomograph parameters were evaluated with the t-test for paired data. A linear regression model was calculated to analyze the relationship between intraocular pressure reduction and visual field changes, and optic nerve head changes. Results Mean intraocular pressure decreased from 24.4 ± 5.0 mm Hg to 12.1 ± 3.1 mm Hg (month 3, Po0.001), and 10.6±2.8 mm Hg (month 6, Po0.001) after trabeculectomy. Mean retinal nerve fiber layer thickness (baseline, 0.19±0.034; month 3, 0.24 ± 0.039, P ¼ 0.05; month 6, 0.21 ± 0.037, P ¼ 0.05) showed a statistical significant change compared with baseline values. Conclusions In this 6-months study, a significant increase in retinal nerve fiber layer thickness was detected after glaucoma filtration surgery.

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Section: Short-term Changes After Trabeculectomy M Figus Et Alsupporting

confidence: 92%

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Short-term changes in the optic nerve head and visual field after trabeculectomy

Figus

Lazzeri

Nardi

et al. 2011

Eye

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“…[10][11][12] These changes might be due to an increase in the prelaminar tissue thickness, an anterior displacement of the LC or a combination of both features. Different authors have supported different hypotheses regarding this controversy.…”

Section: Discussionmentioning

confidence: 99%

“…Optic disc cupping reversal after IOP reduction has been documented in several studies by photography and confocal scanning laser tomography. [9][10][11][12] In the last few years, the advent of the newest OCT devices has improved evaluation of these changes, including the visualisation of the posterior face of the LC. Recently, some studies have reported changes in ONH morphology after trabeculectomy and tube shunt implantation that were assessed by the OCT with EDI technique.…”

Section: Introductionmentioning

confidence: 99%

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Barrancos

Rebolleda

Oblanca

et al. 2013

Eye

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Aim To determine the response of the lamina cribrosa (LC) and prelaminar tissue to a reduction of intraocular pressure (IOP) after nonpenetrating deep sclerectomy (NPDS) using enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). Methods A total of 28 eyes from 28 patients presenting with primary open angle glaucoma who underwent NPDS were studied. SD-OCT scans using EDI technology were obtained before surgery and 1 week, 1 month, and 3 months postoperatively. The OCT device was set to image a 15 Â 101 vertical rectangle centred on the optic disc. The scan closest to the optic nerve head (ONH) centre was selected for analysis. The vertical distances from three equidistant points on the reference line (Bruch's membrane opening) to the anterior prelaminar tissue surface and the anterior and posterior surfaces of the LC were measured. Results The IOP decreased from 18.7 ± 4.3 to 9.1±4.0 at the first week, 11.4±3.7 at 1 month, and 13.1±3.6 mm Hg at 3 months postoperatively (Po0.001). There was a significant reduction of the ONH cupping at 1 week (22.3%, Po0.001), 1 month (13.7%, Po0.001), and 3 months (9.8%, P ¼ 0.001) after surgery. Anterior displacement of the LC was slight but statistically significant at 1 week (4.5%, P ¼ 0.003), 1 month (3.8%, P ¼ 0.014), and 3 months postoperatively (3.3%, P ¼ 0.010). IOP reduction was significantly correlated with a reduction of ONH cupping and anterior displacement of LC at the first week and first month (Po0.05). Conclusions Cupping reversal after NPDS is mainly due to changes in prelaminar tissue thickness, whereas the LC changes in position are less pronounced.

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Assessment of Optic Disc Topography for Diagnosing and Monitoring Glaucoma

Weinreb¹

1998

Arch Ophthalmol

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Change in Optic Disk Topography After Trabeculectomy

Cited by 93 publications

References 11 publications

Short-term changes in the optic nerve head and visual field after trabeculectomy

Short-term changes in the optic nerve head and visual field after trabeculectomy

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Assessment of Optic Disc Topography for Diagnosing and Monitoring Glaucoma

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