1990
DOI: 10.1016/0923-1811(90)90219-4
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Change in sphingomyelinase activity in human epidermis during aging

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Cited by 33 publications
(23 citation statements)
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“…In another recent study, only ceramide content was assessed ( 19), but this study, using a single cyanoacrylate stripping of stratum corneum, demonstrated a decrease in the ceramide content in normal humanaged skin. These workers then correlated the decrease in ceramide content with a decrease in sphingomyelinase activity (43). We, too, found that ceramides were decreased.…”
Section: Discussionmentioning
confidence: 57%
“…In another recent study, only ceramide content was assessed ( 19), but this study, using a single cyanoacrylate stripping of stratum corneum, demonstrated a decrease in the ceramide content in normal humanaged skin. These workers then correlated the decrease in ceramide content with a decrease in sphingomyelinase activity (43). We, too, found that ceramides were decreased.…”
Section: Discussionmentioning
confidence: 57%
“…After the exocytosis of lamellar granules, the lipid components are modified by the action of several hydrolytic enzymes such as sphingomyelinase [7] and glucocerebrosidase [8]. resulting in the final structure of the intercellular lipids, consisting mainly of ceramides.…”
Section: Discussionmentioning
confidence: 99%
“…Extremely high activities of ceramidase 7 and sphingomyelin deacylase 35 , which hydrolyze sphingomyelin into sphingophosphorylcholine and free fatty acid, have been demonstrated to be the metabolic features leading to low levels of ceramides in the SC in AD. The patients with AD in preclinical stages have altered proportions of ceramides in their skin 36,37 as a result of alterations in the activity of enzymes involved in the biosynthetic pathways of ceramide production 38,39 . IgE (IU/ml)…”
Section: Discussionmentioning
confidence: 99%