Changes in aortic collagen in β-aminopropionitrile-induced acute aortic dissection

Zhou, Hao; Ren, Yan; Xiao, Jun; He, Jian; Zhang, Yuling; Qiu, Zhihuang; Huang, Qiuyu; Hu, Yunnan

doi:10.21037/atm-21-4933

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…The daily water-uptake volume of the Control group was significantly higher than that of the Pre-dissection and Dissection groups. These data were consistent with previous reports showing that the weight [18,21,24] and water-uptake volume [21] were decreased after BAPN administration. All experimental data, including the following sections, can be obtained from the Supplementary Materials (Raw data).…”

Section: Body Weight Water-uptake Volume and Aortic-dissection Genera...supporting

confidence: 93%

“…As shown in Figure 6b, the area fraction of collagen in the Pre-dissection group was larger than that in the Control group. Reportedly, the administration of BAPN increased the collagen ratio and disrupted the crosslinks between collagen fibrils and fibers [24]. The same phenomenon would have occurred in the Pre-dissection group; the disruption of the crosslinks by BAPN administration may have reduced the tensile strength of the collagen fibers that aligned in the r direction of the aorta, thus decreasing the delamination strength.…”

Section: Discussionmentioning

confidence: 81%

“…The modulation of the period of administration of BAPN enabled us to prepare models at various stages of AD. Reportedly, AD models exhibit histological changes that are similar to those of natural AD; that is, decreases in interlaminar fibers [23] and increases in collagen [24].…”

Section: Introductionmentioning

confidence: 99%

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Delamination Strength and Elastin Interlaminar Fibers Decrease with the Development of Aortic Dissection in Model Rats

Kurihara,

Ujihara,

Nakamura

et al. 2023

Bioengineering

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Aortic dissection (AD) is a life-threatening tear of the vascular tissue with creation of a false lumen. To explore the mechanism underlying this tissue tear, this study investigated the delamination strength of AD model rats and the histological composition of the aorta at various stages of AD development. SD rats were administrated beta-amino propionitrile for 0 (Control), 3 (Pre-dissection), and 6 (Dissection) weeks. The thoracic aorta was harvested at 10–11 weeks of age. The Dissection group exclusively showed AD at the ascending aorta. The delamination strength, a force that separates the aorta in the radial direction, of the descending aorta decreased significantly in the order of the Control, Pre-dissection, and Dissection groups. A quantitative histological analysis of the aortic tissue demonstrated that, compared with the Control group, the area fraction of collagen was significantly higher in the Pre-dissection and Dissection groups and that of elastin was significantly lower in the Dissection group. The area fraction of the elastin fibers between the elastic laminas (interlaminar fibers) was significantly decreased in the order of the Control, Pre-dissection, and Dissection groups. Histological changes of the aortic tissue, perhaps a reduction in interlaminar fibers mainly aligned in the radial direction, decreased delamination strength, thereby causing AD.

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Section: Body Weight Water-uptake Volume and Aortic-dissection Genera...supporting

confidence: 93%

Section: Discussionmentioning

confidence: 81%