Changes in arterial stiffness, carotid intima-media thickness, and epicardial fat after L-thyroxine replacement therapy in hypothyroidism

Busto-Mesa, Abdel del; Cabrera-Rego, Julio Oscar; Carrero-Fernández, Lisván; Hernández-Roca, Cristina Victoria; González-Valdés, Jorge Luis; Rosa-Pazos, José Eduardo de la

doi:10.1016/j.endoen.2015.06.001

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…There was not a statistically significant difference regarding salusin alpha levels between patients who are under L-thyroxin treatment and those who are not. It is clearly known that L-thyroxin treatment improves the cardiovascular disease risk factors in hypothyroidism (22). However, in our study, salusin alpha levels did not indicate this correlation.…”

Section: Discussioncontrasting

confidence: 96%

Is Salusin-Alpha a New Marker of Cardiovascular Disease Risk in Hypothyroidism?

Atmaca¹

2017

Acta Endo (Buc)

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Introduction. Salusins are multifunctional endogenous peptides shown in human and rat tissues. Serum salusin α level is decreased in coronary artery disease and lack of salusin α enhances coronary atherosclerosis. Hypothyroidism is a chronic inflammatory disease that has a high risk of developing cardiovascular disease. Here we aimed to search the relationship of overt hypothyroidism and subclinical hypothyroidism with salusin α and other inflammatory markers, also the effect of L-thyroxine treatment on these findings. Material and Methods. 32 patients with overt hypothyroidism taking L-thyroxine treatment, 18 patients with subclinical hypothyroidism without treatment and 25 healthy patients as control group were included in the study. Serum salusin α, TNF α, sCRP, glucose, insulin and lipid levels were tested for all groups and results were evaluated with SPSS statistical analysis method. Results. HDL, sCRP, salusin mean values were statistically significantly different in all 3 groups. HDL level was statistically significantly higher in control group compared to treatment group. sCRP level was higher and salusin level was lower in both treatment and non-treatment hypothyroidism groups compared to control group. When treatment and non-treatment hypothyroidism groups were compared, there was no statistically significant difference for salusin α, but HDL level was high and insulin level was low statistically significant in treatment group. Conclusions. Salusin α that is shown to be protective for coronary artery disease and hypertension, is found to be significantly low in hypothyroidism, thus it is a marker that increases the cardiovascular disease risk in this specific patient group.

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Section: Discussioncontrasting

confidence: 96%

Is Salusin-Alpha a New Marker of Cardiovascular Disease Risk in Hypothyroidism?

Atmaca¹

2017

Acta Endo (Buc)

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“…An overview of these and other studies in populations with subclinical hypothyroidism are summarised in Table 3 [32,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]. Markers of atherosclerosis or arterial stiffness improved in some studies [39,52]. A further cross-sectional analysis demonstrated an improvement in atrial volume [53].…”

Section: Effects Of L-thyroxine On Cardiovascular Structure and Functionmentioning

confidence: 99%

“…Two studies showed no significant effects of LT4 replacement on the risk of myocardial infarction, or on cardiovascular and all cause death [49,50]. Intriguingly, there was a suggestion of a greater potential for cardiovascular benefit of LT4 therapy in younger than in older patients [51,52]. A smaller study suggested some cardiovascular benefit for a longer rather than a shorter duration of LT4 treatment [47].…”

Section: Effects Of Lt4 On Major Adverse Cardiovascular Eventsmentioning

confidence: 99%

Levothyroxine and the Heart

Biondi

2021

70 Years of Levothyroxine

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Thyroid hormone deficiency has been associated with multiple changes in cardiovascular structure and function in recent studies. A strong relationship has been reported between overt and subclinical hypothyroidism with serum TSH ≥10 mIU/L and adverse cardiovascular outcomes, suggesting the necessity of replacement doses of Levothyroxine. The potential benefits of replacement therapy remain an active area of research in euthyroid patients with heart failure.

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The Effects of Long-Term High Water Iodine Levels in the External Environment on the Carotid Artery

Bian

Zhang

et al. 2021

Biol Trace Elem Res

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Iodine excess typically affects thyroid function in the human body and may damage carotid artery. Four investigation plots with different water iodine levels were selected in Shandong Province, China. These included a low, medium, and high iodine group and an iodine excess group whose water iodine content was < 10, 50–150, 150–300, and > 300 μg/L, respectively. Residents aged 20–65 years answered a questionnaire and underwent carotid artery ultrasonography, and their height, weight, and urinary iodine concentrations were measured. A total of 2026 individuals participated in the study. Urinary iodine concentration increased with increased water iodine levels. The medial thickening rate and intimal roughness rate in the iodine excess group were significantly higher than in the other three groups. After controlling for factors such as gender, age, and BMI, iodine excess remained as a risk factor for carotid intima-media thickening. Excess water iodine in the external environment is a risk factor for intima-media thickening of the carotid artery, suggesting that iodine excess may cause vascular injury and promote atherosclerosis.

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Changes in arterial stiffness, carotid intima-media thickness, and epicardial fat after L-thyroxine replacement therapy in hypothyroidism

Cited by 6 publications

References 23 publications

Is Salusin-Alpha a New Marker of Cardiovascular Disease Risk in Hypothyroidism?

Is Salusin-Alpha a New Marker of Cardiovascular Disease Risk in Hypothyroidism?

Levothyroxine and the Heart

The Effects of Long-Term High Water Iodine Levels in the External Environment on the Carotid Artery

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