Changes in Biochemical Parameters of the Calcium-Phosphorus Homeostasis in Relation to Nutritional Intake in Very-Low-Birth-Weight Infants

Christmann, Viola; Gradussen, Charlotte J.W.; Körnmann, Michelle N.; Roeleveld, Nel; Goudoever, Johannes B. van; Heijst, Arno F J van

doi:10.20944/preprints201611.0129.v1

Cited by 3 publications

(4 citation statements)

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“…A normal range of Ca/P will lead to optimal bone mineralization and bone formation 17,22,44) . The Ca/P of native bone hydroxyapatite (HA) is 1.67 in human, so most bone related bioactive materials aims at this criteria.…”

Section: Discussionmentioning

confidence: 99%

“…Ca has been proved to be crucial in implant osseointegration, involving platelet adhesion, orientation and conformation of proteins on the interface 20,21) . Low concentration of P is released from bone, which simultaneously lead to the release of Ca because of an unfavorable ratio of Ca to P (Ca/ P) 22) . Interaction between Ca and P could affect bone metabolism and development 23,24) .…”

Section: Introductionmentioning

confidence: 99%

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Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

Liu

Wang

Dong

et al. 2019

J. Hard Tissue Biology.

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The study was to observe dental implant osseointegration at early stage and analysis the influencement of the ratio of calcium and phosphorus variation on osseointegration in hyperlipidemic rats. Wistar rats were randomly divided into control group with normal diet and experimental group with high fat diet. 8 weeks later, serum lipid levels was detected and titanium implants were placed into bilateral femurs. At day1, 3, 5 after implant, rats were sacrificed and 5 mm bone with implants was obtained. hard tissue slices and methylene blue-acid fuchsin staining were performed to observe the interface of bone-implant. And energy disperse X-ray spectrometer (EDS) was used to measure the percentage of oxygen and the ratio of calcium and phosphorus. All rats in experimental group were successfully induced into hyperlipidemic status. Histological results revealed less osteoblasts and trabecular bone, but more osteoclasts and trabecular space in experimental group than those in control group. Higher content of oxygen and lower ration of calcium and phosphorus were also observed in experimental group than those in control group (P<0.05). Hyperlipidemia could hinder implant osseointegration at early stage after implantation. This inhibition might be closely related to higher content of oxygen and lower ratio of calcium and phosphorus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

Liu

Wang

Dong

et al. 2019

J. Hard Tissue Biology.

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“…Focusing on the optimum supply of minerals and of vitamin D, by using human milk fortifier,calcium and phosphorous supplementation or preterm formula is vital to prevent MBD. Supplementing mothers with 600IU/day of vitamin D helps in preventing MBD (52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64). Conclusions Optimum nutritional supplementation of neonates with calcium, phosphorus, vitamin D along with assisted physical exercise plays a key role in preventing MBD.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…Supplementing mothers with 600 IU/day of vitamin D univerasally has also been shown to help in preventing MBD ( 59 ). Focusing on the optimum supply of minerals and of vitamin D, by using human milk fortifier, calcium and phosphorous supplementation or preterm formula is vital to prevent MBD ( 60 , 61 , 62 , 63 , 64 , 65 , 66 ).…”

Section: Diagnosismentioning

confidence: 99%

Metabolic Bone Disease in Premature Neonates: An Unmet Challenge

Chacham

Pasi

Chegondi

et al. 2020

Jcrpe

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The metabolic bone disease is an important morbidity in premature, very low birth weight and sick infants. If left undiagnosed, leads to structural deformities & spontaneous fractures.It is defined as impaired bone mineralization in a neonate with lower than the estimated bone mineral levels in either fetus or neonate of comparable gestational age / weight coupled with biochemical abnormalities with or without radiological manifestations. It has been reported to occur in 16% to 40% of extremely low birth weight neonates. Insufficient calcium and phosphorous stores during the phase of accelerated growth predispose to it along with use of medications (caffeine, steroids), prolonged parenteral nutrition & chronic immobilization. It presents by 6-16 weeks after birth. Enhanced physical activity in preterm infants facilitates bone mineralization and weight gain. Biochemical abnormalities tend to worsen significantly, as the severity of disease progresses. They consist of hypocalcemia, hypophosphatemia, hyperphosphatasia and secondary hyperparathyroidism. In addition, urinary phosphate wasting and hypo vitaminosis D can complicate these abnormalities. Conversely, biochemical abnormalities may not be accompanied by rachitic changes. Newer diagnostic modalities include bone densitometry by quantitative ultrasound over mid-tibial shaft (noninvasive tool). The management of metabolic bone disease includes adequate calcium, phosphorous and vitamin D supplementation along with optimum nutrition and physical activity. Similarly, preventive strategies for metabolic bone disease should target nutritional enhancement alongside enhanced physical activity. Conclusion: Metabolic bone disease is a preventable morbidity in preterm, VLBW neonates and requires optimum nutritional supplementation and enhanced physical activity.

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Growth and Bone Mineralization of Very Preterm Infants at Term Corrected Age in Relation to Different Nutritional Intakes in the Early Postnatal Period

et al. 2017

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Preterm infants often have a reduced bone mineral content (BMC) with increased risk of metabolic bone disease. After birth it is difficult to supply calcium (Ca) and phosphorus (P) comparable to the high fetal accretion rate. It is not known whether high supplementation of minerals in the early postnatal period improves growth and bone mineralization. The aim of this study was to evaluate growth and bone mineralization at term corrected age (TCA) in very and extremely preterm infants who received different enteral Ca and P intakes during the first 10 days of life. Infants (n = 109) with birth weights below 1500 g were randomly assigned to one of three groups that differed in the nutritional protocols delivered until day 10: Group A, mother’s own milk (MOM) and donor milk (unfortified); Group B, MOM (unfortified) and preterm formula; Group C, MOM (start fortification >50 mL/day) and preterm formula. Due to the earlier commencement of fortification, Group C received higher intakes of calcium and phosphorus and protein (p < 0.001) until day 10. At TCA weight, length, BMC and bone mineral density (BMD), measured by dual-X-ray absorptiometry, were not different between the groups. Nutritional intake of P was positively associated with length (β; (95% confidence interval (CI): 0.20 (0.001; 0.393); p-value = 0.048), whereas Ca intake was negatively associated with BMC (−1.94 (−2.78; −1.09); p-value < 0.001). A small interaction between Ca and P intake was only found for BMD (0.003 (0.00002; 0.00006); p-value = 0.036). The volume of human milk per kg provided during the first 10 days was positively associated with BMC (β; (95% CI): 0.013 (0.002; 0.023); p < 0.017). Higher intakes of Ca and P during the first 10 days, as provided in this study, did not improve bone mineralization at term corrected age.

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Changes in Biochemical Parameters of the Calcium-Phosphorus Homeostasis in Relation to Nutritional Intake in Very-Low-Birth-Weight Infants

Cited by 3 publications

References 55 publications

Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

Metabolic Bone Disease in Premature Neonates: An Unmet Challenge

Growth and Bone Mineralization of Very Preterm Infants at Term Corrected Age in Relation to Different Nutritional Intakes in the Early Postnatal Period

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