Changes in biochemical parameters related to atherosclerosis after Helicobacter pylori eradication

Abstract

SUMMARY BackgroundRecent evidence suggests that Helicobacter pylori infection is involved in the pathogenesis of extra-gastrointestinal diseases such as coronary heart disease.

Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese

“…In metabolic risk factors for atherosclerosis, HDL-cholesterol was decreased and TG was slightly increased, although BMI was lower 25) in AG subjects in our study. These results were consistent with previous reports 26,27) . It has been shown that HDL-cholesterol was significantly decreased in HP-positive elderly subjects 28,29) .…”

“…It has been shown that HDL-cholesterol was significantly decreased in HP-positive elderly subjects 28,29) . HDL-cholesterol has been shown to increase after successful eradication of HP 26,27) . It has also been reported that HP affects other lipid profiles, such as total cholesterol 30) , LDL, and lipoprotein-a 28) ; however, total cholesterol and LDL-cholesterol were not different according to AG or HP status.…”

“…For more accurate diagnosis, HP status and AG should be determined by endoscopy and biopsy. Fourth, we did not measure lipoprotein-a 28) , vitamin B12 24) , fibrinogen, and cytokine levels 27) , all of which have been reported to be related to arterial stiffness.…”

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

“…An adversely altered lipid profile, including an increased LDL-c level and decreased HDL-c level, is one of the most important risk factors for atherosclerotic disease. Furthermore, a study performed in Japan showed a significant increase in the HDL-c level and significant decrease in the LDL-c level after successful H. pylori eradication; this effect was sustained over three years of follow-up 128) . Hence, it is conceivable that H. pylori infection functions as a predisposing factor for atherosclerotic processes by modifying the serum lipid profile.…”

Lipid Profile and Helicobacter Pylori infection

“…Both triglycerides and total cholesterol levels decreased gradually (from 132 to 129 mg/dL and from to 170 to 168 mg/dL, respectively) with a significant trend towards an increase in HDL cholesteremia (from 48 to 52 mg/dL; p 0.0201) levels and non-significant decrease in LDL cholesteremia (from 140 to 137 mg/dL; p 0.4136) levels 7) . In a similar study performed in Japan, Ando et al reported a significant increase in HDL cholesteremia levels and a significant decrease in LDL cholesteremia levels after bacterial eradication 8) .…”