Changes in blood center red blood cell distributions in the era of patient blood management: the trends for collection (TFC) study

Zhang

Journal of Viral Hepatitis

et al. 2018

ABO and Rh blood groups play a vital role in blood transfusion safety and clinical practice and are thought to be linked with disease susceptibility. The results from previous studies that focused on the association between blood groups and HBV infection remain controversial. China has the world's largest burden of HBV infection. We assessed the distribution of ABO/Rh blood groups in Chinese adults and examined the association between these groups and HBV infection. We did a nationwide cross-sectional study using data from a physical check-up programme from 31 provinces examined between 2010 and 2012. ELISA was used to test for HBsAg in serologic samples. Multivariable logistic regression was used to estimate aOR of the association between ABO and Rh blood groups and HBV infection. Among 3 827 125 participants, the proportion of participants with blood group A was highest (30.54%), followed by O (30.37%), B (29.42%) and AB (9.66%). A total of 38 907 (1.02%) were Rh-D negative. The prevalence of HBsAg in blood groups O, A, B and AB were 6.34%, 5.55%, 5.18% and 5.06%, respectively. HBsAg prevalence was 5.65% in Rh-D-positive and 3.96% in Rh-D-negative participants. After controlling for other potential risk factors, multivariate models showed that participants with blood group O (adjusted OR = 1.22, 95% CI: 1.20-1.25) were at higher risk of HBV infection compared with group AB. Rh-D-positive participants (adjusted OR = 1.44, 95% CI: 1.37-1.52) were at higher risk of HBV infection than Rh-D-negative participants. The associations between ABO/Rh blood groups and HBV infection were similar in subgroup analysis. The proportions of O, A, B and AB blood groups were approximately 3:3:3:1, and nearly 1 in 100 people was Rh-D negative among Chinese adults. Blood group O and Rh-D positivity were both associated with increased HBV infection. The risk of HBV infection and blood safety should be taken into consideration in clinical practice, especially when transfusing those with blood group O. Awareness and prevention of HBV infection is of particular importance for individuals with blood group O.

Section: Discussionmentioning

confidence: 99%

Distribution of ABO/Rh blood groups and their association with hepatitis B virus infection in 3.8 million Chinese adults: A population‐based cross‐sectional study

Zhang

Journal of Viral Hepatitis

et al. 2018

Isr J Health Policy Res

“…The counter-arguments are:The expected increase of blood donations of currently deferred donors is negligible, adding only 2.1%, 1.0% [3, 9] and 0.3% [9, 22] additional donors with no deferral, 1 year and 5 years deferrals respectively.In Israel, like in other developed countries, a Patient Blood Management Program exists, causing a drop in the usage of blood units and components [30, 31] in times of peace. When an urgent need to increase the national blood inventory arises, it can be achieved by safer means such as increased recruitment of members of the large population group who are not at high risk, who have relatively lower donation propensities.…”

Section: Discussionmentioning

confidence: 99%

“…In Israel, like in other developed countries, a Patient Blood Management Program exists, causing a drop in the usage of blood units and components [30, 31] in times of peace. When an urgent need to increase the national blood inventory arises, it can be achieved by safer means such as increased recruitment of members of the large population group who are not at high risk, who have relatively lower donation propensities.…”

Section: Discussionmentioning

confidence: 99%

Should Men who have sex with Men be allowed to donate blood in Israel?

Ginsberg

Shinar

Kopel

et al. 2016

Self Cite

BackgroundThe present permanent deferral policy in Israel for MSM was established in 1977 and was based on the previous (now outdated) USA Food and Drug Administration standards. This study analyses epidemiological data regarding blood donations among MSM, in order to estimate the risk for HIV transfusion transmitted infection (TTI) if the policy is changed to allow at-risk MSM to donate blood.MethodsAn Excel based spreadsheet model integrated demographic, epidemiological data from the HIV National Register, laboratory, blood donation and testing data in order to calculate TTI due to false-negatives in known HIV+ donors, windows period donations, asymptomatic carriers and laboratory misclassification errors. A sensitivity analysis of our estimated TTIs for deferral periods for MSM was performed based on a literature review regarding this overall policy issue worldwide.ResultsMSM in Israel have a considerably higher relative risk (RR) of both prevalence (115) and incidence (143) of being HIV+ than persons without a risk factor. Allowing MSM to donate blood, without any deferral period, will add an additional five HIV TTI cases over the next decade. Imposition of a 1 or 5 years deferral of abstinence will increase the number of HIV TTI cases only by 0.10 and 0.05 cases, respectively.ConclusionA 1 year deferral period for blood donations from MSM in Israel is recommended.

“…For example, while the combined distributions of B1 and AB1 RBC units as a proportion of the total number of RBC distributions have decreased by 2.6% between 2010 and 2014 at several American and national or provincial blood collectors, the proportion of O-RBC distributions has increased by 10.4% over the same time period at these collectors. 1 Perhaps similar countercurrent trends in antigennegative RBC distributions have also occurred; these are units that hospitals order with a specific antigen phenotype for patients with RBC antibodies or for prophylactic antigen matching in those at risk of becoming alloimmunized, such as patients with sickle cell disease (SCD). [3][4][5] This study was performed to determine if there are …”

mentioning

confidence: 99%

“…1 This is likely in large part due to the increasing adoption of hospitalbased patient blood management programs that tend to decrease the number of RBC units transfused based on a growing body of evidence that does not favor a liberal transfusion strategy for most patients. 2 However, within the larger trend of decreasing overall distributions, some countercurrent trends have developed.…”

mentioning

confidence: 99%

Trends in antigen‐negative red blood cell distributions by racial or ethnic groups in the United States

et al. 2017

Self Cite

BACKGROUND:The overall number of red blood cell (RBC) units distributed to hospitals throughout the world and in the United States has decreased lately. This study was performed to determine if the number of antigennegative RBC units distributed to hospitals has followed this trend. STUDY DESIGN AND METHODS:Stratified by ethnicity, data on total RBC distributions and antigennegative RBC distributions from six large blood collectors in the United States were obtained from 2009 through 2016. An antigen-negative unit was defined as a unit with a specific RBC phenotype that had been specially ordered as such by a hospital. RESULTS:Overall, 10,103,703 RBC units were distributed by these six blood collectors; 650,516 (6.4%) were distributed as antigen-negative units. While the overall number of RBCs distributed decreased by 27.2% between 2009 and 2016, the number of antigen-negative RBC distributions increased by 39.5%. In each year, the majority of the distributed antigen-negative RBCs were donated by whites. However, antigen-negative RBC units from black or African American donors were distributed in a disproportionately high fraction compared to the overall number of RBCs distributed from these donors. Most of the one through four antigen-negative RBCs were donated by whites. However, as antigen matching became more extensive, the proportion of units distributed from black or African American donors increased such that they were the predominant donors of five or more antigen-negative units.CONCLUSION: Blood collectors will need to be aware of the trend of increasing antigen-negative distributions despite decreased overall distributions. I t has been demonstrated that the total number of red blood cell (RBC) units distributed to hospitals worldwide and in the United States over the past several years has been steadily decreasing.1 This is likely in large part due to the increasing adoption of hospitalbased patient blood management programs that tend to decrease the number of RBC units transfused based on a growing body of evidence that does not favor a liberal transfusion strategy for most patients. 2 However, within the larger trend of decreasing overall distributions, some countercurrent trends have developed. For example, while the combined distributions of B1 and AB1 RBC units as a proportion of the total number of RBC distributions have decreased by 2.6% between 2010 and 2014 at several American and national or provincial blood collectors, the proportion of O-RBC distributions has increased by 10.4% over the same time period at these collectors. 1Perhaps similar countercurrent trends in antigennegative RBC distributions have also occurred; these are units that hospitals order with a specific antigen phenotype for patients with RBC antibodies or for prophylactic antigen matching in those at risk of becoming alloimmunized, such as patients with sickle cell disease (SCD). [3][4][5] This study was performed to determine if there are ABBREVIATION: SCD 5 sickle cell disease. developing trends in the number of antige...