Changes in Blood Flow on Optic Nerve Head After Vitrectomy for Rhegmatogenous Retinal Detachment

Iwase, Takeshi; Kobayashi, Misato; Yamamoto, Kentaro; Yanagida, Kosei; Ra, Eimei; Terasaki, Hiroko

doi:10.1167/iovs.16-20577

Cited by 36 publications

(35 citation statements)

References 45 publications

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“…Previous reports showed a relationship between RRD and vascular changes in the macular region. Ito et al 9 described a reduction in the vascular flow in the central retinal artery and the short posterior ciliary artery after scleral buckling, whereas Iwase et al 10 reported a decrease in the retinal blood flow in the optic nerve head using laser speckle flowgraphy for eyes with RRD, which successfully recovered after RRD repair with vitrectomy.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of microvascular changes in the macular area of eyes with rhegmatogenous retinal detachment without macular involvement using swept-source optical coherence tomography angiography

Yoshikawa¹,

Shoji²,

Kanno³

et al. 2018

OPTH

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PurposeTo evaluate microvascular changes in the macular area of eyes with rhegmatogenous retinal detachment (RRD) without macular involvement (macula-on RRD) using swept-source optical coherence tomography angiography (SS-OCTA).Patients and methodsFive patients with macula-on RRD were eligible for analysis. All patients underwent SS-OCTA examination (Triton) for the macular area. The healthy fellow eyes were included as controls. The vessel density (VD) was calculated using binarization, and the foveal avascular zone (FAZ) was measured. The VD and FAZ area were compared between the eyes with RRD and the fellow eyes using the Wilcoxon signed rank test.ResultsThe patients’ clinical characteristics were as follows: age, 49.0 years (21.0, 54.0) (median [25, 75th percentile]); preoperative best-corrected visual acuity, −0.08 (−0.08, 0.11) for RRD and −0.08 (−0.08, −0.03) for the fellow eye (P=0.50); and axial length, 27.0 (25.1, 28.7) mm for RRD and 27.4 (25.6, 28.5) mm for the fellow eye (P=0.31). The parafoveal VD was not significantly different between the eyes with RRD and the fellow eyes (P=1.00 for the superficial retina and P=0.44 for the whole retina). The FAZ area was also similar for the eyes with RRD and the fellow eyes (P=0.31 for the superficial retina and P=0.13 for the whole retina).ConclusionThe findings of this study suggest that the macular microvasculature remains intact in eyes with macula-on RRD.

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Section: Introductionmentioning

confidence: 99%

Evaluation of microvascular changes in the macular area of eyes with rhegmatogenous retinal detachment without macular involvement using swept-source optical coherence tomography angiography

Yoshikawa¹,

Shoji²,

Kanno³

et al. 2018

OPTH

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“…Evaluating the ocular blood flow is an important factor in determining the physiological dynamics of the eye, and the pathogenesis and treatment of various ocular diseases, including diabetic retinopathy, 1 , 2 glaucoma, 3 , 4 retinal detachment, 5 , 6 branch retinal vein occlusion (BRVO), 7 , 8 and central serous chorioretinopathy (CSC). 9 , 10 Hayreh and Zimmerman 11 reported that the retinal sector most affected by a major BRVO was the superior temporal quadrant at 65%, and the inferior temporal quadrant at 31% of the eyes.…”

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confidence: 99%

Differences in Blood Flow Between Superior and Inferior Retinal Hemispheres

Tomita

Iwase

Ueno

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Purpose To determine whether the blood flow in the superior retina is significantly different from that in the inferior retina, and to determine whether the posture affects the blood flow in the superior and inferior retina. Methods The blood flow in the vessels around the optic nerve head was measured by laser speckle flowgraphy in the sitting position in 68 healthy subjects. The blood flow in the superior peripapillary retina was compared with that in the inferior peripapillary retina. The measurements of the blood flow were performed in the sitting position, and the effect of switching to a supine position was determined at 2, 4, 6, 8, 10, and 30 minutes after the switch. Results The total relative flow volume (RFV)-all, RFV-artery, and RFV-vein were significantly greater in the superior retina than in the inferior retina (all P < 0.001). The mean diameter-all and mean diameter-artery in the superior retina were significantly larger than that in the inferior retina (all P < 0.05). The mean blur rate (MBR)-all, MBR-artery, and MBR-vein in the superior retina were also greater than that in the inferior retina ( P < 0.001, P < 0.01, and P < 0.001, respectively). Although the ocular perfusion pressure was significantly changed with the postural alteration, the total RFV-all remained greater in the superior retina than in the inferior retina after the postural change. Conclusions Clinicians need to be aware of the differences in the blood flow between the superior and inferior retinal peripapillary area when considering the mechanisms of retinochoroidal diseases.

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“…Likewise, the MBR in the vessel and tissue regions was significantly lower in hyperlipidemia patients 19 . Studies have shown that MBR-MT was stable regardless of age 10 and did not significantly affect in the eyes with the macula 20 . These are because MV consists of large vessels, whereas MT represents small capillaries and the choroidal area.…”

Section: Discussionmentioning

confidence: 97%

Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model

Ismail

Chen

Faye

et al. 2020

Sci Rep

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Real-time impairment of ocular blood flow (OBF) under common carotid artery stenosis (CCAS) has not been ascertained. We aimed to longitudinally assess the impact of CCAS on OBF using a rabbit model. About 75% stenosis was created by tying the common carotid artery with a plastic mandrel using a nylon suture. The plastic mandrel was gently removed, leaving a ligature. Neurological and behavioral assessments were recorded as the clinical indicator of stroke severity. With laser speckle flowgraphy, the pulse waveform parameters namely mean blur rate (MBR), blowout score (BOS), blowout time (BOT), rising rate, S1-area, falling rate (FR), S2-area, flow acceleration index (FAI), acceleration time index, resistive index (RI) and the difference between the maximum and minimum values of MBR (AC) were assessed in overall, vessel, and tissue regions of the optic nerve head (ONH). Longitudinally, BOS significantly increased until day 19 post-surgery, whereas FAI, RI, and AC significantly decreased. Beyond day 19, BOS, BOT, FR, FAI, RI, and AC significantly decreased. We defined two stages representing impaired vessel conditions, namely the vessel resistance phase, where BOS increases and FAI, RI, and AC decrease, and the vessel elasticity phase where BOS, BOT, FR, FAI, RI and AC decrease. These stages provide information about atherosclerosis, assessable non-invasively through the eye.

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Changes in Blood Flow on Optic Nerve Head After Vitrectomy for Rhegmatogenous Retinal Detachment

Abstract: These results indicate that the retinal blood flow is reduced in eyes affected by RRD preoperatively, and can recover following successful RRD repair by vitrectomy.

Cited by 36 publications

References 45 publications

Evaluation of microvascular changes in the macular area of eyes with rhegmatogenous retinal detachment without macular involvement using swept-source optical coherence tomography angiography

Evaluation of microvascular changes in the macular area of eyes with rhegmatogenous retinal detachment without macular involvement using swept-source optical coherence tomography angiography

Differences in Blood Flow Between Superior and Inferior Retinal Hemispheres

Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model

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