Changes in Blood Indicators in Case of Use of Bis[bis(3,5-Dimethylpyrazol-1-Yl)acetato]copper(ii) Complex After Burn Injuries

Abstract

Burn injuries cause profound changes in hematological parameters. The degree of severity of such changes and the speed of development of disturbances depend on the quantitative parameters of the injuries (area and degree of damage). One of the most urgent modern healthcare problems is the search and development of new effective approaches and medications for healing burn injuries. Radioprotectors differ by their effectiveness and duration of their protective action. For the purpose of promotion of tissue regeneration after burn injuries, medications with anti-inflammatory, analgesic and pro-regenerative properties are used. In this regard, copper-based complexes are of particular interest. The biogenic role of copper includes its participation in the processes of hematopoiesis. Copper also plays an important role in neutralizing the toxins of microorganisms, in prolongation of the action of antibacterial medications, as well as in reducing inflammatory reactions. The use of copper sulfate promotes the acceleration of skin regeneration in burn wounds, and Cu complexes show low toxicity. The aim of the study is to identify a possible positive effect of the bis[bis(3,5-dimethylpyrazol-1-yl)acetato]copper(II) complex, Cu[HC(COO)(pzMe2)2]2, in case of burns. As a result of hematological and cytogenetic studies, it was found that Cu[HC(COO)(pzMe2)2]2 has the ability to prevent or reduce the pathological processes in case of deep burns. The findings were also confirmed by survival assessments (100%).