Changes in blood–retinal barrier permeability in form deprivation myopia in tree shrews

Abstract

To study the correlation between blood-retinal barrier (BRB) permeability and development of form deprivation (FD) myopia, FD was induced in tree shrews. The refractive error and the axial dimensions of the optical elements were measured. Ocular fluorescence was measured before and after fluorescein-Na injection. The inward permeability (P(in)) of the BRB was measured before and 15, 30, and 45 days after FD was induced. FD eyes became significantly myopic 15 days after FD was induced (P<0.01), and myopia progressed 45 days after FD was induced compared with untreated controls. Neither anterior chamber length nor lens thickness changed significantly. The vitreous chamber in FD eyes, however, was significantly elongated from 15 days after FD was induced (P<0.01) compared with controls. The P(in) ratio (P(in) [FD eye]/P(in) [untreated control]), increased significantly 45 days after FD was induced (P<0.05). In FD myopia in tree shrews, the BRB permeability increases abnormally. Impaired BRB function might be a secondary effect of myopia development rather than the cause of myopia.

Characteristics of patients with a favorable natural course of myopic choroidal neovascularization

“…Fluorescein fundus angiography sometimes detects a window defect around CNV due to RPE atrophy and the area of the window defect then develops into a typical chorioretinal atrophy (data not shown). RPE function is affected in myopic eyes [8,11,20]. Aging is another factor that influences RPE function [4,5].…”

Factors associated with the development of chorioretinal atrophy around choroidal neovascularization in pathologic myopia

“…In the process of chorioretinal atrophy development around the regressed CNV, we sometimes find that first a window defect due to RPE atrophy appears around the CNV, as seen on fluorescein fundus angiography, and then the area of window defect develops into a typical chorioretinal atrophy (not shown). RPE function is affected in myopic eyes [7,10,19]. Aging is also another important influence on RPE function [4,5].…”

Myopic Maculopathy: A Review

“…Pathological myopia even without any chorioretinal degeneration has been shown to be associated with an early functional impairment of the outer retina when studied by electrophysiological and psychophysiological methods [22,23,24]. Also, RPE dysfunction has been described in highly myopic eyes [25,26,27]. …”