Changes in body composition and energy expenditure after six weeks' growth hormone treatment.

Pfadt, Albert; Angulo, Moris

doi:10.1136/adc.66.10.1261-a

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…GH replacement therapy in children with PWS accelerates linear growth and improves energy expenditure, body composition, physical strength, agility, pulmonary function and predicted final AH [Pfadt and Angulo, 1991;Angulo et al, 1996;Carrel et al, 1999;Lindgren and Ritzen, 1999;Obata et al, 2003;Haqq et al, 2003].…”

Section: Introductionmentioning

confidence: 99%

Final adult height in children with Prader–Willi syndrome with and without human growth hormone treatment

Angulo

Castro‐Magana

Lamerson

et al. 2007

American J of Med Genetics Pt A

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Short stature is characteristic of children with Prader-Willi syndrome (PWS). While previous studies have demonstrated acceleration of linear height velocity with growth hormone (GH) treatment, the long-term benefit on final adult height (AH) has not been reported. The objective of this study was to compare AH attained in PWS subjects with and without GH treatment. We reviewed the records of 21 children (aged 8.3 +/- 2.7 years) with PWS and confirmed GH deficiency that attained AH after receiving human GH treatment (0.25 +/- 0.06 mg/kg/week) for a period of 7.9 +/- 1.7 years. A group of 39 non-GH-treated adults with matched initial height standard deviation score (SDS) at age 6.8 +/- 1.3 years was used as control. In the GH-treated group the mean initial height and AH-SDS was -1.9 +/- 1.7 and -0.3 +/- 1.2 respectively (P < 0.0001), whereas the mean initial and AH-SDS in the control group was -1.9 +/- 1.3 and -3.1 +/- 1 respectively (P < 0.0001). Scoliosis was seen in 43% and 39% in the GH-treated and control group respectively. Premature adrenarche (PA) was noticed in 57% of GH-treated group. Six subjects in the control group but none of the GH-treated subjects developed type 2 diabetes mellitus. Our data show that administration of GH to children with PWS restores linear growth and final AH without significant adverse effects other than PA. Further studies will be necessary to determine related morbidity and mortality in individuals with PWS that reached final AH with or without GH treatment.

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Section: Introductionmentioning

confidence: 99%

Final adult height in children with Prader–Willi syndrome with and without human growth hormone treatment

Angulo

Castro‐Magana

Lamerson

et al. 2007

American J of Med Genetics Pt A

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“…The U.S. Food and Drug Administration approved the use of GH in individuals with PWS in 2000. GH therapy for PWS individuals has dramatic effects, including an increase in linear growth, muscle mass, and fat utilization as well as a decrease in total body fat (2)(3)(4)(5). The greatest changes occur during the first 12 months of GH therapy (4,6).…”

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confidence: 97%

Short-Term Effects of Growth Hormone on Sleep Abnormalities in Prader-Willi Syndrome

Miller¹,

Silverstein²,

Shuster

et al. 2006

The Journal of Clinical Endocrinology & Metabolism

122

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Most of our PWS patients had improvement after short-term GH treatment, but 32% had worsening of sleep disturbance. A subset of PWS patients are at risk during this window of vulnerability shortly after initiation of GH. Because it is difficult to predict who will worsen with GH, patients with PWS should have PSA before and after starting GH and should be monitored for sleep apnea with upper respiratory tract infections. Otorhinolaryngological evaluation is warranted if sleep apnea worsens on GH. IGF-I levels should be monitored, with the goal being physiological levels.

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Changes in body composition and energy expenditure after six weeks' growth hormone treatment.

Cited by 2 publications

References 2 publications

Final adult height in children with Prader–Willi syndrome with and without human growth hormone treatment

Final adult height in children with Prader–Willi syndrome with and without human growth hormone treatment

Short-Term Effects of Growth Hormone on Sleep Abnormalities in Prader-Willi Syndrome

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