Changes in cerebral haemodynamics, regional oxygen saturation and amplitude-integrated continuous EEG during hypoxia-ischaemia and reperfusion in newborn piglets

Ioroi, Tomoaki; Peeters-Scholte, Cacha; Post, Ilka; Leusink, Cheraar; Groenendaal, Floris; Bel, Frank van

doi:10.1007/s00221-002-1030-z

Cited by 28 publications

(15 citation statements)

References 37 publications

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“…The pattern of aEEG in piglets after HI resembles best the situation in the human newborn affected by perinatal asphyxia (12). The immediate drop in amplitude we observed at the start of the HI period, similar in VEH and CBD, reflects the severity of the insult (13,25) and is due to the decrease in neuronal metabolism that protects the brain cells against further injury (12).…”

Section: Discussionsupporting

confidence: 60%

“…The aim of the present work was to study the neuroprotective effect of CBD by using the temporary occlusion of both carotid arteries combined with hypoxia animal model, considered as very close to actual perinatal asphyxia in human neonates (12). In addition, we aimed to test the protective effect of CBD by using the two best devices available for actual bedside studies in asphyxiated newborns: near-infrared spectroscopy (NIRS), a noninvasive optical technique for assessing circulation and oxygenation in brain, and amplitudeintegrated electroencephalography (aEEG).…”

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confidence: 99%

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Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

Álvarez¹,

Lafuente²,

Rey-Santano³

et al. 2008

Pediatr Res

132

113

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ABSTRACT:To test the neuroprotective effects of the nonpsychoactive cannabinoid cannabidiol (CBD), piglets received i.v. CBD or vehicle after hypoxia-ischemia (HI: temporary occlusion of both carotid arteries plus hypoxia). Nonhypoxic-ischemic sham-operated piglets remained as controls. Brain damage was studied by near-infrared spectroscopy (NIRS) and amplitudeintegrated electroencephalography (aEEG) and by histologic assessment (Nissl and FluoroJadeB staining). In HIϩvehicle, HI led to severe cerebral hemodynamic and metabolic impairment, as reflected in NIRS by an increase in total Hb index (THI) and a decrease in the fractional tissue oxygenation extraction (FTOE); in HIϩCBD the increase of THI was blunted and FTOE remained similar to SHAM. HI profoundly decreased EEG amplitude, which was not recovered in HIϩvehicle, indicating cerebral hypofunction; seizures were observed in all HIϩvehicle. In HIϩCBD, however, EEG amplitude recovered to 46.4 Ϯ 7.8% baseline and seizures appeared only in 4/8 piglets (both p Ͻ 0.05). The number of viable neurons decreased and that of degenerating neurons increased in HIϩvehicle; CBD reduced both effects by more than 50%. CBD administration was free from side effects; moreover, CBD administration was associated with cardiac, hemodynamic, and ventilatory beneficial effects. In conclusion, administration of CBD after HI reduced short-term brain damage and was associated with extracerebral benefits. (Pediatr Res 64: 653-658, 2008)

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Section: Discussionsupporting

confidence: 60%

mentioning

confidence: 99%

Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

Álvarez¹,

Lafuente²,

Rey-Santano³

et al. 2008

Pediatr Res

132

113

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“…44 With cerebral TOI values approaching this level in the prone position, preterm infants may be at risk for critically impaired cerebral TOI during hypoxic or hypotensive episodes occurring during sleep.…”

Section: Figurementioning

confidence: 99%

Cerebral Oxygenation in Preterm Infants

et al. 2014

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BACKGROUND AND OBJECTIVE: Prone sleeping is a major risk factor for sudden infant death syndrome (SIDS) and preterm infants are at significantly increased risk. In term infants, prone sleeping is associated with reduced mean arterial pressure (MAP) and cerebral tissue oxygenation index (TOI). However, little is known about the effects of sleeping position on TOI and MAP in preterm infants. We aimed to examine TOI and MAP in preterm infants after term-equivalent age, during the period of greatest SIDS risk. METHODS: Thirty-five preterm and 17 term infants underwent daytime polysomnography, including measurement of TOI (NIRO-200 spectrophotometer, Hamamatsu Photonics KK, Japan) and MAP (Finapress Medical Systems, Amsterdam, Netherlands) at 2 to 4 weeks, 2 to 3 months, and 5 to 6 months postterm age. Infants slept prone and supine in active and quiet sleep. The effects of sleep state and position were determined by using 2-way repeated measures analysis of variance and of preterm birth by using 2-way analysis of variance. RESULTS: In preterm infants, TOI was significantly lower when prone compared with supine in both sleep states at all ages (P < .05). Notably, TOI was significantly lower in preterm compared with term infants at 2 to 4 weeks, in both positions (P < .05), and at 2 to 3 months when prone (P < .001), in both sleep states. MAP was also lower in preterm infants in the prone position at 2 to 3 months (P < .01). CONCLUSIONS: Cerebral oxygenation is reduced in the prone position in preterm infants and is lower compared with age-matched term infants, predominantly in the prone position when MAP is also reduced. This may contribute to their increased SIDS risk.

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“…The various methods applied to induce hypoxia and/or ischemia include, among others, reduction of the fraction of inspired oxygen, either by placing newborn piglets in a hypoxia chamber with a reduced ambient oxygen tension [7] or by decreasing the inspiratory oxygen percentage in mechanically ventilated piglets [10]. The latter method has also been conducted with simultaneous occlusion of both carotid arteries [11,12].…”

Section: Introductionmentioning

confidence: 99%

Umbilical cord clamping in term piglets: A useful model to study perinatal asphyxia?

et al. 2008

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Perinatal asphyxia results in tissue and cellular changes during the reperfusion period and clinical signs like perinatal mortality and decreased vitality at birth in newborn piglets. This study aimed to develop and validate a model of birth asphyxia, mimicking the evolvement of birth asphyxia in natural farrowings by conducting umbilical cord clamping (UCC) in term piglets during caesarean sections under general anaesthesia. In total 23 piglets were subjected to 5-8 min of UCC and 24 piglets served as controls. Acid-base balance values and heart rates measured before UCC remained fairly constant throughout the surgical procedure, indicating nearly identical starting conditions of piglets within and between litters. UCC resulted in a significant, mild, mixed respiratory-metabolic acidosis (pH 7.22, pCO 2 9.8 kPa, BE ecf 2 mmol/L, lactate 6.5 mmol/L; controls: pH 7.31, pCO 2 8.5 kPa, BE ecf 5 mmol/L, lactate 4 mmol/L) at 10 min after birth (defined as simultaneous cutting of the umbilical cord and removal of a plastic bag that had been placed over the head to avoid air intake). Heart rates were significantly decreased during UCC (range: 83-107 beats/min versus 128-134 beats/ min in controls). Rectal temperatures and changes in body weight until 72 h of life were not affected by UCC. Interestingly, four control and seven clamped piglets did not survive as no independent respiration could be attained. Birth weights and duration of UCC of these piglets did not differ significantly from those in surviving control and clamped piglets. In conclusion the mixed respiratory-metabolic acidosis arising in the surviving clamped piglets is not as severe as can be expected in highly asphyxiated, vaginally delivered newborn piglets. Repeatability of the model is compromised by considerable variation in the individual response to UCC. #

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Changes in cerebral haemodynamics, regional oxygen saturation and amplitude-integrated continuous EEG during hypoxia-ischaemia and reperfusion in newborn piglets

Cited by 28 publications

References 37 publications

Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

Cerebral Oxygenation in Preterm Infants

Umbilical cord clamping in term piglets: A useful model to study perinatal asphyxia?

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