Changes in Choroidal Vascularity Index (CVI) in Intermediate Uveitis

Kongwattananon, Wijak; Kumar, Aman; Oyeniran, Enny; Sen, H. Nida; Kodati, Shilpa

doi:10.1167/tvst.10.14.33

Cited by 11 publications

(7 citation statements)

References 34 publications

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“…Indeed, CVI changes with treatment response are also controversial in the literature. Patients with acute VKH syndrome showed a signi cant reduction in CVI after corticosteroid treatment 32,33 whereas CVI values were found to be increased with the resolution of in ammation in patients with VKH and intermediate uveitis 13,24 In the present study, the fact that we did not nd a signi cant change in CVI after ADA treatment could be a sign of an ongoing systemic in ammatory process. Although 24 weeks of ADA therapy reduced in ammation in the anterior and posterior segments and decreased MT, it may be concluded that this was not enough time to change the choroidal vascular or stromal structures.…”

Section: Discussioncontrasting

confidence: 46%

“…25 On the other hand, CVI was found to be decreased when granulomatous anterior uveitis appeared in patients with VKH 26 and intermediate uveitis. 13 Similarly, three recent studies have reported decreased CVI values in eyes with both JIAassociated uveitis and FUS compared to non-uveitic fellow eyes and healthy control individuals. [26][27][28] The authors proposed that continuous in ammation results in in ammation-mediated thinning in the vascular area of the choroid.…”

Section: Discussionmentioning

confidence: 89%

“…12 Enhanced-depth imaging OCT (EDI-OCT), in turn, is a non-invasive technique that provides deeper choroidal accessibility and visibility. 13 The choroid's vascular-luminal area (LA), interstitial-stromal area (SA), and subfoveal-total choroidal area (TCA) can be measured separately using EDI-OCT. The novel choroidal vascularity index (CVI) is then calculated as the ratio of LA/TCA that demonstrates the % proportion of vascularity within the choroidal tissue.…”

Section: Introductionmentioning

confidence: 99%

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Effect of adalimumab on choroidal thickness and choroidal vascularity index in eyes with non-infectious uveitis using enhanced-depth imaging optical coherence tomography

Evereklioğlu

Arslantas²,

Şener

et al. 2023

Preprint

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Objective To evaluate the effect of adalimumab (ADA) on choroidal thickness (ChT) and choroidal vascularity index (CVI) in eyes with non-infectious uveitis (NIU). Methods Thirty-seven eyes with NIU, 38 eyes of non-uveitic (NU) patients, and 40 control eyes were included. ADA was used for anti-TNF-naive adult (80mg) or pediatric (40mg) patients with refractory NIU, then 40mg every 2-week (20mg in children < 30kg) with controls at weeks 1, 4, 12, and 24. Images were used to measure central, nasal, and temporal ChT, and the luminal area (LA), stromal area (SA), and total choroidal area (TCA) were analysed using enhanced-depth imaging optical coherence tomography (EDI-OCT) by ImageJ software. The CVI was then calculated as the ratio of LA to TCA. Results Mean ages were similar between the groups. Mean (SE) subfoveal ChT measurements for each location were also similar (for each, p > 0.05). However, calculated CVI values in eyes with NIU (0.63 ± 0.007) were significantly (p < 0.001) lower than NU eyes (0.66 ± 0.006) and controls (0.70 ± 0.007) (p < 0.001). Moreover, CVI was significantly lower in NU eyes compared to controls (p < 0.001). There were no significant CVI changes between the consecutive visits after ADA therapy in eyes with NIU (for each, p > 0.05). Conclusions Decreased CVI in NIU and NU eyes indicates that systemic inflammation affects the choroidal vasculature and perfusion both in the presence and absence of ocular involvement. Although CVI may be used as a possible novel tool in monitoring ocular involvement and progression of NIU, CVI does not seem to be a biomarker for treatment monitoring in NIU.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Effect of adalimumab on choroidal thickness and choroidal vascularity index in eyes with non-infectious uveitis using enhanced-depth imaging optical coherence tomography

Evereklioğlu

Arslantas²,

Şener

et al. 2023

Preprint

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“…Notably, postoperative GRT eyes, particularly eyes that underwent vitrectomy combined with SB, had significantly lower LA, TCA, CVI, and CFA values than fellow control eyes. Lower postoperative CVI, with respect to the controls, has previously been reported following posterior eye surgeries [ 47 – 49 ], possibly due to the resolution of inflammation or other triggers that initially increased CVI in the first place. Our findings for buckled eyes contrasted with a recent report in which Bernabei et al [ 33 ] found no difference in CVI postoperatively between control and operated eyes.…”

Section: Discussionmentioning

confidence: 70%

Postoperative Choroidal Vascular Biomarkers in Eyes with Rhegmatogenous Retinal Detachment-Related Giant Retinal Tears

Quiroz-Gonzalez

Lima-Gómez

2023

Int J Retin Vitr

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Purpose Choroidal vascularity index (CVI) and choriocapillaris flow area (CFA) are perfusion biomarkers relevant to retinal disease management. There is limited knowledge regarding these biomarkers in eyes that have been successfully treated for rhegmatogenous retinal detachment (RRD) due to giant retinal tears (GRTs). This study aimed to analyze the relationship between choroidal perfusion biomarkers and functional outcomes in surgically treated eyes with GRT-associated RRD and their fellow eyes. Methods A total of 33 GRT eyes and 29 fellow eyes were included in this study. All RRD-GRT eyes were treated with vitrectomy and categorized into two groups based on whether additional scleral buckles (SB) were placed. Visual and choroidal features were compared between the groups. Results The subjects had an average age of 55.18 years, a mean time of 2.36 weeks before surgery, and a mean follow-up time of 25.9 months. Best-corrected visual acuity (BCVA) was substantially worse in GRT eyes (1.9 logMAR) than in fellow control eyes (0.23 logMAR) but substantially improved after surgery (0.59 logMAR). There were no differences in the presurgical characteristics and BCVA between the eyes that did and did not undergo SB. Long-term CVI and CFA were lower in eyes with GRT than in their fellow eyes. Among eyes with GRT, those with SB had significantly lower CVI and CFA. Correlation analysis revealed that the CVI and CFA were positively correlated with visual outcomes (negative correlation with logMAR). Conclusion Despite successful surgical repair, long-term functional and choroidal evaluations showed permanent changes in eyes with GRT. Positive correlations between perfusion biomarkers and visual function suggest that better choroidal vasculature is associated with better visual outcomes. The results of this study highlight the benefits of analyzing choroidal vasculature biomarkers and the relationship between the choroidal anatomy and vision.

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“…The non-signi cant trend towards either 2D CVI (p = 0.055) or baseline 3D CVI (p = 0.177) being increased at 6-month follow-up compared to that of baseline in uveitis patients is consistent with the ndings of Kongwattananon et al In their study, 2D CVI in eyes presenting with intermediate uveitis was higher (p < 0.001) at follow-up (68.82% ± 3.90%), than that of baseline (66.50% ± 3.40%). 25 However, con icting results were found in a study by Kim et al, where eyes with acute HLA-B27-associated uveitis exhibited reduced 2D CVI upon uveitis resolution. Such a disparity could be due to uveitis etiological heterogeneity as HLA-B27-associated uveitis most commonly presents as anterior uveitis.…”

Section: Discussionmentioning

confidence: 96%

Optical Coherence Tomography-Based Choroidal Vascularity Index: Tracking Uveitis Progression Over Time

Agrawal,

Wei,

Loh

et al. 2024

Preprint

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Objectives To investigate longitudinal changes in choroidal vascularity index (CVI) in uveitis patients with active inflammation at baseline, and at six months. Methods This prospective comparative study included 49 eyes of 49 patients with anterior, intermediate, posterior or panuveitis, and 49 eyes of 49 healthy controls. Uveitis patients were recruited at baseline with active inflammation. Clinical data and multimodal imaging including optical coherence tomography were obtained at baseline and six months. Both two-dimensional (2D) subfoveal CVI and three-dimensional (3D) macular CVI were measured using previously published algorithms. Comparison between uveitis and control group as well as between baseline visit and 6 months visit in the uveitis group were performed using ANCOVA model. Results At baseline, 2D CVI was lower in the uveitis group (62.4% vs 63.8%, p = 0.007) and 3D CVI also showed a lower trend in the uveitis group (62.0% vs 62.8%, p = 0.109) compared to that of healthy subjects. Within the uveitis group, both 2D and 3D CVI were higher at 6 months compared to baseline, but both were not significant (p = 0.055 and 0.177, respectively). Uveitis patients who were still clinically active at 6 months had lower 2D and 3D CVI at baseline compared to those who were clinically quiescent at 6 months (p = 0.027 and p = 0.008, respectively). Conclusions Changes in CVI are correlated with the diagnosis and prognosis of uveitis patients. Lower CVI values at baseline were associated with persistent inflammation after 6 months of follow-up. Thus, CVI may be a useful outcome measure in uveitis management and clinical trials.

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Changes in Choroidal Vascularity Index (CVI) in Intermediate Uveitis

Cited by 11 publications

References 34 publications

Effect of adalimumab on choroidal thickness and choroidal vascularity index in eyes with non-infectious uveitis using enhanced-depth imaging optical coherence tomography

Effect of adalimumab on choroidal thickness and choroidal vascularity index in eyes with non-infectious uveitis using enhanced-depth imaging optical coherence tomography

Postoperative Choroidal Vascular Biomarkers in Eyes with Rhegmatogenous Retinal Detachment-Related Giant Retinal Tears

Optical Coherence Tomography-Based Choroidal Vascularity Index: Tracking Uveitis Progression Over Time

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