Changes in circulating insulin-like growth factor-I, insulin-like growth factor binding proteins, and leptin in weaned pigs infected with Salmonella enterica serovar Typhimurium

Jenkins, N.; Turner, John P.; Dritz, S. S.; Durham, Susan K.; Minton, J. Ernest

doi:10.1016/j.domaniend.2003.09.001

Cited by 31 publications

(20 citation statements)

References 14 publications

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“…infantis was not associated with hepatic expression of the IGF system despite previous studies that identified reduced serum IGF-1 and IGFBP-3 in pigs colonized with Salmonella (Jenkins et al, 2004). The lack of association observed in the present investigation may be because of the limited number of liver samples used for RT-qPCR from pigs colonized with Salmonella (n = 6).…”

Section: Discussioncontrasting

confidence: 94%

“…In pigs, it has been observed that reduced concentrations of serum IGF-1 are associated with infection of Mycoplasma hyopneumoniae, porcine reproductive and respiratory syndrome virus (PRRSV; Roberts and Almond, 2003) and Salmonella typhimurium (Jenkins et al, 2004). However, the nutritional-independent mechanisms responsible for these changes are not well understood.…”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory factors and infectious agents associated with the hepatic gene expression of the IGF system in nursery pigs

Slifierz

Friendship

Lange

et al. 2014

Animal

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Recent findings suggest there is a complex interaction between the IGF system and the inflammatory immune response. The objective of this study was to determine whether gene expression of growth factors (IGF-1, IGF-binding protein-3 (IGFBP-3) and growth hormone receptors (GHR)) in the liver is associated with gene expression of immunomodulators in the liver, including C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), interferon-α (IFN-α), IFN-γ, tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-10 and IL-18, as well as with the presence of Salmonella spp., Lawsonia intracellularis, Brachyspira spp., enterotoxigenic Escherichia coli, methicillin-resistant Staphylococcus aureus, swine influenza virus, and porcine reproductive and respiratory syndrome virus (PRRSV) in nursery pigs (n = 74) from commercial farms (n = 4). Gene expression was quantified using reverse transcription quantitative-PCR (RT-qPCR) and the data were modelled using logistic regression methods. Pigs with elevated IGF-1 expression were less likely to have increased expression of TNF-α (odds ratio (OR) = 0.14, P < 0.01) and IL-18 (OR = 0.19, P < 0.05), and less likely to be colonized with PRRSV (OR = 0.03, P < 0.01). Pigs with increased expression of IGFBP-3 were more likely to have elevated IL-6 expression (OR = 8.5, P < 0.05). It was also observed that IGFBP-3 and IGF-1 were significantly associated when Hp expression was low (OR = 30, P < 0.05), but this association was not significant when Hp expression was high ( P = 0.54). Pigs with increased expression of GHR were less likely to have elevated expression of SAA (OR = 0.01, P < 0.05) and IL-1β (OR = 0.03, P < 0.05), but more likely to have increased expression of CRP (OR = 290, P < 0.01). Overall, there appears to be an inverse association between the hepatic expression of the IGF system (IGF-1, IGFBP-3, GHR) and certain cytokines (IL-1β, IL-18, TNF-α) and acute-phase proteins (SAA, Hp).

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Section: Discussioncontrasting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Immunomodulatory factors and infectious agents associated with the hepatic gene expression of the IGF system in nursery pigs

Slifierz

Friendship

Lange

et al. 2014

Animal

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“…Our laboratory has published findings from weaned pigs challenged with the same isolate of Typhimurium as used in the current study and we have noted its effects on several variables in pigs, including known systemic mediators of growth and development (Balaji et al, 2000;Turner et al, 2002a,b;Jenkins et al, 2004). However, the single oral dosages used for bacterial challenge were greater in the previous experiments, ranging from 10 9 to 10 10 cfu.…”

Section: Discussionmentioning

confidence: 41%

“…Infection by Salmonella enterica serovar Choleraesuis (hereafter referred to as Choleraesuis), another important swine pathogen, is more likely to cause septicemia in growing pigs (Schwartz, 1999), but little has been reported comparing these 2 serovars in terms of their effects on key regulatory elements of the endocrine growth axis. We have previously shown that infection by Typhimurium results in unmistakable effects on systemic markers of the somatotropic growth axis, namely, serum IGF-I (Balaji et al, 2000;Burkey et al, 2004) and IGFBP-3, in pigs (Jenkins et al, 2004). In the current study, our objective was to directly compare the effects of oral inoculation with Typhimurium and Choleraesuis on weaned pigs because each serovar produces differing effects on swine, with Typhimurium producing mainly self-limiting enteritis and Choleraesuis, a so-called swine host-adapted pathogen, being more likely to result in a more serious and occasionally fatal septicemia (Schwartz, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…In swine, oral infection by Salmonella enterica serovar Typhimurium (hereafter referred to as Typhimurium) results in growth suppression and an array of associated physiological effects (Schwartz, Oral inoculation with Salmonella enterica serovar Typhimurium or Choleraesuis promotes divergent responses in the somatotropic growth axis of swine Balaji et al, 2000;Jenkins et al, 2004). Infection by Salmonella enterica serovar Choleraesuis (hereafter referred to as Choleraesuis), another important swine pathogen, is more likely to cause septicemia in growing pigs (Schwartz, 1999), but little has been reported comparing these 2 serovars in terms of their effects on key regulatory elements of the endocrine growth axis.…”

Section: Introductionmentioning

confidence: 99%

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Oral inoculation with Salmonella enterica serovar Typhimurium or Choleraesuis promotes divergent responses in the somatotropic growth axis of swine1

Davis

Fraser

Burkey

et al. 2010

Journal of Animal Science

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Enteric disease and immune challenge are processes that have detrimental effects on the growth performance of young swine. The current study tested the hypothesis that salmonella-induced enteric disease would perturb the endocrine growth axis in a serovar-dependent fashion. Specifically, we evaluated the effects of Salmonella enterica serovar Typhimurium (Typhimurium) and serovar Choleraesuis (Choleraesuis) on critical regulatory components of growth in young swine. Weaned pigs were housed 2 per pen with ad libitum access to feed and water in a 14-d experiment. Pigs were then repeatedly fed 10 8 cfu of either Choleraesuis or Typhimurium in dough balls, with control pigs receiving dough without bacteria. Bacteria were refed twice weekly. Rectal temperatures were monitored daily from d 0 to 7 and ADFI was measured through d 14. Pigs were weighed and samples of serum were obtained for circulating IGF-I on d 0, 7, and 14. At the conclusion of the study, samples of semitendinosus muscle and liver were obtained and subsequently assayed for IGF-I, IGFBP-3, and IGFBP-5 mRNA. Rectal temperatures were elevated in pigs given Choleraesuis from d 2 through 7 (P < 0.05) when compared with control pigs and pigs fed Typhimurium. Pigs receiving Choleraesuis had a substantially decreased feed intake on d 2, 3, 4, 7, 8, 9, and 10 (P < 0.01), with a trend for a reduction on d 5 (P = 0.08), and they experienced an approximately 25% reduction in BW compared with control pigs and pigs given Typhimurium by the conclusion of the study. Pigs given Choleraesuis also experienced marked reductions in circulating IGF-I on d 7 (P < 0.01 vs. control and Typhimurium), with reductions of lesser magnitude on d 14 (P = 0.07 vs. control and P < 0.05 vs. Typhimurium). Inoculation tended to affect liver IGFBP-3 mRNA (P = 0.08), for which expression tended to be elevated in pigs given Typhimurium and Choleraesuis. In contrast, IGFBP-3 mRNA relative abundance was increased (P < 0.03) in pigs given Typhimurium compared with control pigs. Muscle IGF-I mRNA was reduced in pigs given Choleraesuis compared with control pigs and pigs given Typhimurium (P < 0.05). Treatment tended to affect muscle IGFBP-3 mRNA (P = 0.10). Oral inoculation of growing pigs with Choleraesuis disrupted feed intake and BW gain, and this was accompanied by decreases in circulating IGF-I and reduced muscle expression of mRNA for IGF-I and IGFBP-3.

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Effects of milk feeding, frequency and concentration on weaning and buffalo (Bubalus bubalis) calf growth, health and behaviour

Vecchio

Palo

Carlo

et al. 2013

Trop Anim Health Prod

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Growth, weight at birth and daily weight gain (DWG) on 12 water buffalo calves, starting from 6 days of age until completion of weaning, was investigated in this study. Different feeding regimens were given to two groups of animals with regard to daily milk replacer: (1) group 1 (G1) received a double concentration in single administration; whereas (2) group 2 (G2) received the same amount of milk replacer split twice daily. Blood samples were collected from each calf on days 6, 30, 60 and 90 to evaluate acute phase proteins (haptoglobin), bactericide activity, lysozime, total protein content and biochemical parameters. No differences were observed between the two groups in terms of dry matter intake, feed efficiency and live body weight at the end of the study. Interestingly, a significantly (P < 0.05) reduced DWG was observed earlier in G1 (day 45) than in G2 (day 60). Gastrointestinal disorders were not recorded throughout the experimental period, and no significant differences were recorded between the two groups for all considered parameters. This study confirms the possibility of utilising one daily administration of milk replacer in water buffalo calf during weaning. This new approach facilitates calves management, without interfering with calves growing performances.

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Changes in circulating insulin-like growth factor-I, insulin-like growth factor binding proteins, and leptin in weaned pigs infected with Salmonella enterica serovar Typhimurium

Cited by 31 publications

References 14 publications

Immunomodulatory factors and infectious agents associated with the hepatic gene expression of the IGF system in nursery pigs

Immunomodulatory factors and infectious agents associated with the hepatic gene expression of the IGF system in nursery pigs

Oral inoculation with Salmonella enterica serovar Typhimurium or Choleraesuis promotes divergent responses in the somatotropic growth axis of swine1

Effects of milk feeding, frequency and concentration on weaning and buffalo (Bubalus bubalis) calf growth, health and behaviour

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