1983
DOI: 10.1016/0006-8993(83)90290-1
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Changes in cortical and subcortical levels of monoamines and their metabolites following unilateral ventrolateral cortical lesions in the rat

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Cited by 40 publications
(10 citation statements)
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“…Thus, microglia in vivo may reveal neurotoxic effects via producing NO under certain conditions [12]. Some advantages of our injury model are that the stereotaxic operation seems to produce less damage to other places in the brain than other models such as needle-penetrating wounds, and suction on the brain surface [24,25]; and necrotic damage seems to be free from hemorrhage and infection owing to the coagulating and sterilizing effects of ethanol [12]. We performed PET scanning for only those rats that showed a high intensity area around the ethanol injected right ST on the T2-weighted images for the ideal injury model.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, microglia in vivo may reveal neurotoxic effects via producing NO under certain conditions [12]. Some advantages of our injury model are that the stereotaxic operation seems to produce less damage to other places in the brain than other models such as needle-penetrating wounds, and suction on the brain surface [24,25]; and necrotic damage seems to be free from hemorrhage and infection owing to the coagulating and sterilizing effects of ethanol [12]. We performed PET scanning for only those rats that showed a high intensity area around the ethanol injected right ST on the T2-weighted images for the ideal injury model.…”
Section: Discussionmentioning
confidence: 99%
“…Rats were prepared for cortical ablation (Finklestein et al, 1983) by removing 4 ϫ 2 mm strip of frontal bone; a 3 ϫ 1 mm strip of anterior medial frontal cerebral cortical tissue was then ablated unilaterally, using fine forceps and gentle aspiration through a glass pipette held parallel to the cortical surface at the A-P coordinate ϭ 2.7-5.2 mm (all coordinates are based on the atlas of Paxinos and Watson, 1982). This lesion removed most of the unilateral frontal cerebral cortex with its predominant ipsilateral corticostriatal projections (McGeorge and Faull, 1989) and avoided direct damage to the CPu.…”
Section: Frontal Cerebral Cortical Lesionsmentioning
confidence: 99%
“…Six days after unilateral, ventrolateral cortical lesions, 5-HT and NA were decreased ipsilaterally, whereas 5-HIAA was increased. 69 Unilateral, focal cortical freezing or heat lesion both decreased 5-HT levels bilaterally after 1 d, whereas 5-HIAA increased and remained elevated up to 10 ld. 70 Subsequently, this group could show an ipsilateral increase in 5-HT synthesis in the cortex, hippocampus, and DRN using the same model.…”
Section: Tbi and Monoamine Turnovermentioning
confidence: 99%